Vitamin K supplementation in cystic fibrosis

Hoorn, Jeroen H. L. van

doi:10.1136/adc.88.11.974

Cited by 32 publications

(21 citation statements)

References 7 publications

(7 reference statements)

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“…Given that a dose of 10 mg of vitamin K per week is considered to be too high for CF children [28] and that a 1-year treatment is too short to improve BMD, we suggest that long-term vitamin K supplementation may ultimately result in an improved BMD in CF patients.…”

Section: Discussionmentioning

confidence: 96%

“…Pathogenetic factors of osteoporosis in CF patients include chronic inflammation, delayed puberty, hypogonadism, glucocorticoid therapy, limited physical activity, poor tolerance to sun exposure, malnutrition and vitamin D malabsorption. Recent evidence suggests that vitamin K deficiency also plays an important role in the pathogenesis of decreased bone mineralization in CF patients [2,28,29].…”

Section: Introductionmentioning

confidence: 99%

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The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis

Nicolaidou

Stavrinadis²,

Loukou

et al. 2006

Eur J Pediatr

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis

Nicolaidou

Stavrinadis²,

Loukou

et al. 2006

Eur J Pediatr

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“…In these patients, supplemental vitamin K may help the anti-osteoporotic treatment efficacy probably by promoting post-translational γ-carboxylation of osteocalcin which favors calcium binding in bone. In 20 children with CF, vitamin K in a dose of 10 mg/week for 1 year increased serum markers of bone formation, and decreased markers of bone resorption and serum PTH (37).…”

Section: Corrections Of Complementary Disturbancesmentioning

confidence: 99%

Osteoporosis and inflammation

Lacativa

Farias

2010

Arq Bras Endocrinol Metab

197

138

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SUMMARYSeveral inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, celiac disease, cystic fibrosis and chronic obstructive pulmonary disease have been associated to bone resorption. The link between osteoclast, macrophage colony stimulating factor and pro-inflammatory cytokines, especially tumor necrosis factor-α and interleukin-1 explain the association between inflammation and osteoporosis. These diseases are related to osteoporosis and high fracture risk independent of other risk factors common to inflammatory diseases such as reduced physical activity, poor nutritional status, hypovitaminosis D, decrease in calcium intake and glucocorticoid treatment. Erythrocyte sedimentation rate and C-reactive protein should always be performed, but the indication about when to perform the densitometry test should be analyzed for each disease. Bisphosphonates are nowadays the best choice of therapy but new medications such as denosumab, IL-1 receptor antagonist, and TNF-α antibody have risen as new potential treatments for osteoporosis secondary to inflammation. Arq Bras Endocrinol Metab. 2010;54(2):123-32 Keywords Osteoporosis; inflammation; arthritis, rheumatoid; lupus erythematosus, systemic; interleukin-1; tumor necrosis factor-alpha SUMÁRIO Diversas doenças inflamatórias têm sido associadas à reabsorção óssea, como a artrite reumatoide, o lúpus eritematoso sistêmico, a doença inflamatória intestinal, a doença celíaca, a fibrose cística e a doença pulmonar obstrutiva crônica. A ligação entre osteoclastos, fator estimulador de colônia de macrófagos e citocinas pró-inflamatórias, principalmente o fator de necrose tumoral-α e interleucina-1, explica a associação entre a inflamação e a osteoporose. Essas doenças estão relacionadas com osteoporose e aumento do risco de fratura, independentemente de outros fatores de risco comuns às doenças inflamatórias, tais como redução da atividade física, estado nutricional, hipovitaminose D, diminuição da ingestão de cálcio e uso de glicocorticoides. A velocidade de hemossedimentação e proteína C-reativa devem ser sempre realizadas, mas a indicação do exame de densitometria óssea deve ser analisada em cada doen ça. Os bisfosfonatos são atualmente a melhor opção de terapia, mas novos medicamentos, tais como denosumabe, antagonista do receptor de IL-1 e anticorpos anti-TNF-α, surgem como novos potenciais tratamentos para a osteoporose secundária à inflamação. Arq Bras Endocrinol Metab. 2010;54(2):123-32 Descritores Osteoporose; inflamação; artrite reumatoide; lúpus eritematoso sistêmico; interleucina-1; fator de necrose tumoral-alfa

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“…32 De manera similar, Hoorn y col. documentaron concentraciones significativamente más altas de PIVKA-II en los pacientes con FQ e insuficiencia pancreática que no recibían vitamina K (n= 10) o que recibían una dosis baja (< 0,25 mg/día) (n= 6) en comparación con los sujetos sanos (n= 19). 33 La hepatopatía también está indicada como uno de los factores de riesgo de deficiencia de vitamina K en los pacientes con FQ. 14 Mosler y col. demostraron concentraciones normales de PIVKA-II solamente en dos de 15 sujetos con FQ con hepatopatía que recibían ácido ursodesoxicólico por vía oral debido a una actividad elevada de la GGT.…”

Section: Tabla 5 Análisis De Regresión Múltiple Escalonada Hacia Adeunclassified

Prevalencia de deficiencia de vitamina K y factores asociados en pacientes con fibrosis quística sin aporte suplementario

Krzyżanowska

Drzymała-Czyż

Rohovyk³

et al. 2018

Arch Argent Pediatr

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Vitamin K supplementation in cystic fibrosis

Cited by 32 publications

References 7 publications

The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis

The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis

Osteoporosis and inflammation

Prevalencia de deficiencia de vitamina K y factores asociados en pacientes con fibrosis quística sin aporte suplementario

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