Vitamin K Antagonists and Cognitive Impairment: Results From a Cross-Sectional Pilot Study Among Geriatric Patients

Annweiler, Cédric; Ferland, Guylaine; Barberger‐Gateau, Pascale; Brangier, Antoine; Rolland, Yves; Beauchet, Olivier

doi:10.1093/gerona/glu133

Cited by 35 publications

(27 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistently, a link between the use of VKAs and worse cognitive performance was previously highlighted in older adults [7]. These results were confirmed in three longitudinal studies reporting greater cognitive decline and executive dysfunction among those using VKA, even after adjustment for a history of atrial fibrillation and stroke [8-10].…”

Section: Introductionsupporting

confidence: 68%

See 1 more Smart Citation

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Brangier¹,

Celle²,

Roche³

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. Methods: In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33.3% female; mean exposure 2,122 ± 1,799 days) and 36 matched participants using no VKA (mean age 75 ± 5 years; 33.3% female) underwent MRI scanning of the brain. Cortical grey and white matter volumes were automatically segmented using statistical parametric mapping. Age, gender, educational level, history of atrial fibrillation, type of MRI, and total intracranial volume were included as covariables. Results: The duration of exposure to VKA correlated inversely across the whole brain with the subvolumes of two clusters in the grey matter (right frontal inferior operculum and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the use of VKA. Conclusion: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults.

show abstract

Section: Introductionsupporting

confidence: 68%

“…In humans, clinical epidemiological studies have shown associations of the use of VKAs with cognitive disorders [5, 7] and decline of executive functions [8, 9]. Conversely, very few studies have examined the impact of the use of VKAs on brain structure.…”

Section: Discussionmentioning

confidence: 99%

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Brangier¹,

Celle²,

Roche³

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…Evidence shows that individuals with AD often have low serum concentrations of vitamin K [63][64][65]. Furthermore, geriatric patients that use vitamin K antagonists as anticoagulant medications suffer more frequent cognitive impairment than patients not prescribed these medications [66]. Vitamin K is involved in neuron development and survival through anti-apoptotic and anti-inflammatory effects which are mediated by Gas 6, protein S, and sphingolipids [67].…”

Section: Vitamin Kmentioning

confidence: 99%

Diet Associated with Inflammation and Alzheimer’s Disease

Vasefi

Hudson

Ghaboolian-Zare

2019

ADR

View full text Add to dashboard Cite

Neurocognitive disorders, such as Alzheimer's disease (AD), affect millions of people worldwide and are characterized by cognitive decline. Human and animal studies have shown that chronic immune response and inflammation are important factors in the pathogenesis of AD. Chronic inflammation can accelerate the aggregation of amyloid-␤ peptides and later hyperphosphorylation of tau proteins. The exact etiology of AD is not clear, but genetics and environmental factors, such as age, family history, and lifestyle are linked to neurodegenerative diseases. Lifestyle habits, such as poor diet, are associated with inflammation and could accelerate or slow down the progression of neurodegenerative diseases. Here we provide a review of the potential conditions and factors that stimulate the inflammatory processes in AD. An understanding of inflammatory mechanisms influencing the development of AD may help to protect against dementia and AD.

show abstract

“…A possible role of vitamin K in AD-pathogenesis is further given by the discovery of a positive correlation between the serum vitamin K level and the cognitive functions of AD patients [147,148]. Additionally, the use of vitamin K antagonists as anticoagulant medications is associated with a more frequent cognitive impairment among geriatric patients [149]. …”

Section: Vitamin Kmentioning

confidence: 99%

The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease

Grimm

Mett

Hartmann

2016

IJMS

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly population, currently affecting 46 million people worldwide. Histopathologically, the disease is characterized by the occurrence of extracellular amyloid plaques composed of aggregated amyloid-β (Aβ) peptides and intracellular neurofibrillary tangles containing the microtubule-associated protein tau. Aβ peptides are derived from the sequential processing of the amyloid precursor protein (APP) by enzymes called secretases, which are strongly influenced by the lipid environment. Several vitamins have been reported to be reduced in the plasma/serum of AD-affected individuals indicating they have an impact on AD pathogenesis. In this review we focus on vitamin E and the other lipophilic vitamins A, D, and K, and summarize the current knowledge about their status in AD patients, their impact on cognitive functions and AD risk, as well as their influence on the molecular mechanisms of AD. The vitamins might affect the generation and clearance of Aβ both by direct effects and indirectly by altering the cellular lipid homeostasis. Additionally, vitamins A, D, E, and K are reported to influence further mechanisms discussed to be involved in AD pathogenesis, e.g., Aβ-aggregation, Aβ-induced neurotoxicity, oxidative stress, and inflammatory processes, as summarized in this article.

show abstract

Vitamin K Antagonists and Cognitive Impairment: Results From a Cross-Sectional Pilot Study Among Geriatric Patients

Abstract: We found more frequent cognitive impairment associated with the use of VKAs, specifically fluindione, among geriatric patients.

Cited by 35 publications

References 14 publications

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Diet Associated with Inflammation and Alzheimer’s Disease

The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease

Contact Info

Product

Resources

About