Vitamin E: Recommended Intake

Schwarzová, Marianna; Fatrcová-Šramková, Katarí­na; Tvrdá, Eva; Kačániová, Miroslava

doi:10.5772/intechopen.97381

Cited by 4 publications

(2 citation statements)

References 73 publications

(96 reference statements)

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“…The other 25 patients were administered topical corticosteroids. In addition, one capsule of 400 mg oral systemic vitamin E supplement* was prescribed once daily in the morning (24).…”

Section: Group a (Test Group)mentioning

confidence: 99%

Clinical Evaluation of Adjunctive Oral Systemic Vitamin E Therapy in Patients With Erosive Oral Lichen Planus (A Randomized Controlled Clinicalc Trial)

Shakir,

Adam,

Gaweesh

2024

Alexandria Dental Journal

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BACKGROUND: Oral lichen planus (OLP) is a chronic autoimmune disorder. It mostly involves the skin, mucous membrane, and rarely the scalp and nails. It is an inflammatory condition driven by T-cells. Traditional treatment for OLP is topical steroids, which are frequently used to treat lesions with mild to moderate symptoms. Recent treatment modalities for oral lichen planus include micronutrients as antioxidants, including vitamin E, that modify the immune system function. AIM OF THE STUDY:The purpose of this study is to assess the clinical response to adjunctive oral systemic vitamin E therapy in erosive oral lichen planus patients. MATERIALS AND METHODS: 50 patients participated in this randomized, controlled clinical study. The erosive OLP patients were split into two parallel groups: 25 in group A, patients were administered oral systemic vitamin E adjunctive to topical corticosteroids. Group B: 25 patients received topical corticosteroids alone. Clinically, treatment responses were evaluated according to Thongprasom et al. scoring system before and after both treatment modalities. RESULTS: After 4 and 8 weeks of treatment, there was a significant decline in the Thongprasom scores in the research groups. Both the mean score values for the outcomes after four and eight weeks were more prominent in the test group. Throughout the clinical experiment, the test and control groups were statistically different. CONCLUSION: Systemic vitamin E adjunctive to topical corticosteroids has shown promising effects in the management of OLP with no side effects.

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“…The other 25 patients were administered topical corticosteroids. In addition, one capsule of 400 mg oral systemic vitamin E supplement* was prescribed once daily in the morning (24).…”

Section: Group a (Test Group)mentioning

confidence: 99%

Clinical Evaluation of Adjunctive Oral Systemic Vitamin E Therapy in Patients With Erosive Oral Lichen Planus (A Randomized Controlled Clinicalc Trial)

Shakir,

Adam,

Gaweesh

2024

Alexandria Dental Journal

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“…The officially recommended daily intake (RDI) of 12–15 mg/d vitamin E in Germany is based on its biological activity against lipid peroxidation [ 51 ]. Numerous foods including nuts, seeds, and some sorts of vegetable oil act as natural sources of vitamin E. Moreover, vitamin E is also widely used as a legal additive in food processing.…”

Section: Characteristics Of Vitamin Ementioning

confidence: 99%

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E

Młynarska,

Biskup,

Możdżan

et al. 2024

Antioxidants

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Hypertension stands as a pervasive global health challenge, contributing significantly to mortality rates worldwide. Various factors, including lifestyle choices and dietary habits, contribute to the development of hypertension. In recent years, oxidative stress has garnered significant attention as a factor influencing hypertension risk, prompting a shift in research focus towards exploring it as a potential target for prevention and treatment. Antioxidants found in our diet, such as vitamins C, E and carotenoids exhibit the ability to neutralize reactive oxygen species, thereby mitigating oxidative stress. In addition, Vitamin A has an antioxidant effect despite not being an antioxidant itself. Consequently, supplementation or increased intake of these antioxidants has been hypothesized to potentially lower blood pressure levels and aid in the management of hypertension, thereby potentially prolonging life expectancy. Research findings regarding this effect have been diverse. This paper examines the existing literature demonstrating favorable outcomes associated with antioxidant supplementation.

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Vitamin E: Recommended Intake

Cited by 4 publications

References 73 publications

Clinical Evaluation of Adjunctive Oral Systemic Vitamin E Therapy in Patients With Erosive Oral Lichen Planus (A Randomized Controlled Clinicalc Trial)

Clinical Evaluation of Adjunctive Oral Systemic Vitamin E Therapy in Patients With Erosive Oral Lichen Planus (A Randomized Controlled Clinicalc Trial)

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E

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