Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials

Donnelly, Jennifer; Appathurai, Amanda; Yeoh, Hui-Ling; Driscoll, Kate; Faisal, Wasek

doi:10.3390/nu14204329

Cited by 13 publications

(5 citation statements)

References 42 publications

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“…This well-known antioxidant, which can protect against oxidative stress conditions through its scavenger action, is commonly administered to ameliorate the toxic effects of chemotherapy [ 49 ], which, according to our results, would be counterproductive in antitumor Cannabis treatments, as it would significantly reduce their efficacy.…”

Section: Discussionmentioning

confidence: 70%

Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Sánchez-Sánchez

García

Fernández

et al. 2023

IJMS

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Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. Tetrahydrocannabinol and cannabidiol are the main compounds present in Cannabis sativa, and both exert their actions through a receptor-mediated mechanism and through a non-receptor-mediated mechanism, which modulates the formation of reactive oxygen species. These oxidative stress conditions might trigger lipidic changes, which would compromise cell membrane stability and viability. In this sense, numerous pieces of evidence describe a potential antitumor effect of cannabinoid compounds in different types of cancer, although controversial results limit their implementation. In order to further investigate the possible mechanism involved in the antitumoral effects of cannabinoids, three extracts isolated from Cannabis sativa strains with high cannabidiol content were analyzed. Cell mortality, cytochrome c oxidase activity and the lipid composition of SH-SY5Y cells were determined in the absence and presence of specific cannabinoid ligands, with and without antioxidant pre-treatment. The cell mortality induced by the extracts in this study appeared to be related to the inhibition of the cytochrome c oxidase activity and to the THC concentration. This effect on cell viability was similar to that observed with the cannabinoid agonist WIN55,212-2. The effect was partially blocked by the selective CB1 antagonist AM281, and the antioxidant α-tocopherol. Moreover, certain membrane lipids were affected by the extracts, which demonstrated the importance of oxidative stress in the potential antitumoral effects of cannabinoids.

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Section: Discussionmentioning

confidence: 70%

Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Sánchez-Sánchez

García

Fernández

et al. 2023

IJMS

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“…The mechanisms by which vitamin E operates include the inhibition of the NF-κB pathway, suppression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity, and neutralization of reactive nitrogen and oxygen species [97]. Despite these actions, a review of randomized controlled clinical trials from 2012 to 2022 did not conclusively confirm the beneficial effects of vitamin E in treating cancers, particularly those affecting the female genital tract [98]. While vitamin E has been proposed as a potential cancer preventative agent, there is evidence suggesting that antioxidants might, in some cases, enhance the survival and proliferation of cancer cells [99,100].…”

Section: Vitamin C E and Kmentioning

confidence: 99%

Vitamins in Gynecologic Malignancies

Wierzbowska,

Olszowski,

Chlubek

et al. 2024

Nutrients

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The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to single-drug treatments. Combining cisplatin with calcitriol and progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer. The effectiveness of vitamin derivatives in anticancer treatment may vary depending on the characteristics of the tumor and the cell line from which it originated. An increase in thiamine intake of one unit is associated with an 18% decrease in HPV infection. Higher intake of vitamin C by 50 mg/day is linked to a lower risk of cervical neoplasia. Beta-carotene, vitamin C, and vitamin E are associated with risk reductions of 12%, 15%, and 9% in endometrial cancer, respectively. A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitamins and metabolic markers and clinical outcomes.

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“…A review summarized a significant number of studies demonstrating the effects of vitamin E related to the suppression or overexpression of main tumorigenic pathways, mostly associated with breast cancer progression, proliferation, metastasis, tumor energy metabolism, and its effects in combination with chemotherapy drugs ( de Oliveira et al, 2021 ). Nevertheless, conflicting results have been observed in randomized clinical trials evaluating vitamin E isoforms in human cancer treatment and pathophysiological processes associated with anticancer drugs ( Donnelly et al, 2022 ). These results do not allow to make a meaningful conclusion on the beneficial role of vitamin E in cancer therapy.…”

Section: Antioxidants That Potentially Can Be Used For the Developmen...mentioning

confidence: 99%

Potential use of antioxidants for the treatment of chronic inflammatory diseases

Blagov,

Summerhill,

Sukhorukov

et al. 2024

Front. Pharmacol.

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The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the development of a state of oxidative stress, with serious biological consequences. The consequences of oxidative stress depend on the balance between the generation of reactive oxidant species and the antioxidant defense and include oxidative damage of biomolecules, disruption of signal transduction, mutation, and cell apoptosis. Accumulating evidence suggests that oxidative stress is involved in the physiopathology of various debilitating illnesses associated with chronic inflammation, including cardiovascular diseases, diabetes, cancer, or neurodegenerative processes, that need continuous pharmacological treatment. Oxidative stress and chronic inflammation are tightly linked pathophysiological processes, one of which can be simply promoted by another. Although, many antioxidant trials have been unsuccessful (some of the trials showed either no effect or even harmful effects) in human patients as a preventive or curative measure, targeting oxidative stress remains an interesting therapeutic approach for the development of new agents to design novel anti-inflammatory drugs with a reliable safety profile. In this regard, several natural antioxidant compounds were explored as potential therapeutic options for the treatment of chronic inflammatory diseases. Several metalloenzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, are among the essential enzymes that maintain the low nanomolar physiological concentrations of superoxide (O2•−) and hydrogen peroxide (H2O2), the major redox signaling molecules, and thus play important roles in the alteration of the redox homeostasis. These enzymes have become a striking source of motivation to design catalytic drugs to enhance the action of these enzymes under pathological conditions related to chronic inflammation. This review is focused on several major representatives of natural and synthetic antioxidants as potential drug candidates for the treatment of chronic inflammatory diseases.

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Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials

Cited by 13 publications

References 42 publications

Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma

Vitamins in Gynecologic Malignancies

Potential use of antioxidants for the treatment of chronic inflammatory diseases

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