Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysis

Fiorino, Sirio; Reggiani, Maria Letizia Bacchi; Leandri, Paolo; Loggi, Elisabetta; Andreone, Pietro

doi:10.4254/wjh.v9.i6.333

Cited by 18 publications

(12 citation statements)

References 62 publications

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“…Similarly, supplementation of vitamin E (200 IU/day) did not have a statistically significant effect on lower respiratory tract infections in elderly nursing home residents [97] . However positive effects of vitamin E have been observed in the treatment of chronic hepatitis B in a small pilot RCT, where a significantly higher normalization ofliver enzymes and HBV-DNA negativization, was observed in the vitamin E group [98] .Similar results have been observed in a RCT in the paediatric population, where vitamin E treatment resulted in a higher anti-HBe seroconversion and virological response [99] .…”

Section: Vitamin Esupporting

confidence: 70%

Review:antiviral and Immunomodulatory Properties of Nutraceuticals and Herbs

Kamath¹,

Yadav²

2020

IJAR

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viral life cycle, such as viral entry, replication, assembly, and release, as well as on the targeting of virushost-specific interactions. In this brief report, we summarize the antiviral activities from several natural products and herbal medicines against some notable viral pathogens including coronavirus (CoV), coxsackievirus (CV), dengue virus (DENV), enterovirus 71 (EV71), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus, human immunodeficiency virus (HIV), influenza virus, measles virus (MV), and respiratory syncytial virus (RSV). [3] About one-quarter of marketed orthodox pharmaceutical medicines is either derived from plantsources or from derivatives of secondary plant metabolites.The success of obtaining new drugs from naturalsources is not very encouraging. Several factors are responsiblefor such observation. Atpresent, of about 2000 varieties of minor illnesses andserious diseases only 40% have cure using conventionalorthodox pharmaceuticals. Variouschemicals and biotechnological products are beingscreened by major multinational pharmaceutical industriesin the hope of discovering new cures for diseases. [4] Complementary and alternative medicine offers a wide variety of herbal plants, which may serve as key to unlock the many mysteries behind human pathologies. According to a World Health Organization (WHO) report, 80 % of the population in developing countries depends on traditional plants for health requirements. [5] Natural products such as herbal plant extracts (used in Ayurveda as mentionedinCharaka Samhita and Susruta Samhita or other traditional medicine practices), plant derived compounds (also known as phytoconstituents), extracts of specific plant parts (roots, stem, bark, flowers, fruits and seeds), dietary supplements and nutraceuticals find wide application in treating ailments ranging from common to rare infectious and non-infectious diseases. [6],[7] This review mainly focuses on the effect of herbs and nutraceutical on respiratory health and on viral infections; however, other studies on viral infections have also been included. Finally, practical recommendations have been drawn on both preventive and therapeutic nutritional interventions. Antiviral and Immunomodulatory Effects of Herbs: The history of the use of herbs as medication is as old as history itself. Some authors state that the first recorded use of herbs for medical treatment began over 4000 years ago. [8] Theorigin of this type of medical treatment began in China and India. Traditional Chinese medicine centres on interactions between the body and the environment. A mixture of treatments, including herbs, acupuncture, and massage, is then prescribed. Traditional Indian medicine has dated back to 3 000 BC. [9] Andrographis paniculate: Andrographis paniculata, commonly known as the "king of bitters," is an herbaceous plant belonging to the Acanthaceae and is found throughout tropical and subtropical Asia, Southeast Asia, and India. In India, A.paniculatais known as "Kalmegh" [10],[11]. Andrographolide is ...

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Section: Vitamin Esupporting

confidence: 70%

Review:antiviral and Immunomodulatory Properties of Nutraceuticals and Herbs

Kamath¹,

Yadav²

2020

IJAR

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“…In a small pilot RCT protective effects of vitamin E have been reported by treatment of chronic hepatitis B [ 112 ]. Similar study in the pediatric population showed that vitamin E supplementation led to a higher anti-HBe seroconversion and viral response [ 113 ]. Suggested contributing mechanisms were the improvement of effective immune synapse formation in naive T cells and the initiation of T cell activation signals, the reduction of prostaglandin E 2 (PGE2) production by the inhibition of COX2 activity mediated through decreasing NO production, and the modulation of Th1/Th2 balance [ 114 ].…”

Section: Nutrients and Bioactive Compoundsmentioning

confidence: 86%

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Askari

Sanadgol

Azarnezhad

et al. 2021

Heliyon

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Recently, the novel coronavirus disease 2019 , has attracted the attention of scientists where it has a high mortality rate among older adults and individuals suffering from chronic diseases, such as chronic kidney diseases (CKD). It is important to elucidate molecular mechanisms by which COVID-19 affects the kidneys and accordingly develop proper nutritional and pharmacological strategies. Although numerous studies have recently recommended several approaches for the management of COVID-19 in CKD, its impact on patients with renal diseases remains the biggest challenge worldwide. In this paper, we review the most recent evidence regarding causality, potential nutritional supplements, therapeutic options, and management of COVID-19 infection in vulnerable individuals and patients with CKD. To date, there is no effective treatment for COVID-19-induced kidney dysfunction, and current treatments are yet limited to anti-inflammatory (e.g. ibuprofen) and anti-viral medications (e.g. Remdesivir, and Chloroquine/Hydroxychloroquine) that may increase the chance of treatment. In conclusion, the knowledge about kidney damage in COVID-19 is very limited, and this review improves our ability to introduce novel approaches for future clinical trials for this contiguous disease.

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“…Vitamin E supplementation has been proposed as a therapy for chronic hepatitis B with good results (Andreone et al 2001) (Fiorino et al 2017). However, vitamin E and/or multivitamin-mineral supplementation have not presented good results for acute respiratory tract infections in elderly patients (Graat, Schouten, and Kok 2002).…”

Section: Obesity Nutrition and Viral Immune Responsementioning

confidence: 99%

Obesity as a risk factor for COVID-19: an overview

Alberca

Oliveira

Branco

et al. 2020

Critical Reviews in Food Science and Nutrition

125

127

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The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for healthcare systems worldwide. Many different risk factors are associated with disease severity, such as older age, diabetes, hypertension, and most recently obesity. The incidence of obesity has been on the rise for the past 25 years, reaching over 2 billion people throughout the world, and obesity itself could be considered a pandemic. In this review, we summarize aspects involved with obesity, such as changes in the immune response, nutritional factors, physiological factors, and the gutlung axis, that impact the viral response and the COVID-19 prognosis.

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Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysis

Cited by 18 publications

References 62 publications

Review:antiviral and Immunomodulatory Properties of Nutraceuticals and Herbs

Review:antiviral and Immunomodulatory Properties of Nutraceuticals and Herbs

Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives

Obesity as a risk factor for COVID-19: an overview

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