Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort

Lykkedegn, Sine; Beck-Nielsen, Signe Sparre; Sørensen, Grith Lykke; Andersen, Louise Bjørkholt; Fruekilde, Palle Bach Nielsen; Nielsen, Jan; Kyhl, Henriette Boye; Joergensen, Jan Stener; Husby, Steffen; Christesen, Henrik Thybo

doi:10.1016/j.clnu.2016.10.008

Cited by 21 publications

(33 citation statements)

References 23 publications

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“…Interesting results were reported by Lykkedegn et al, who demonstrated a U-shaped association between neonatal weight at birth and cord blood vitamin D concentrations. A significant weight gain was observed after the concentration values exceed 24 ng/ml ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

et al. 2018

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IntroductionVitamin D deficiency in pregnant women may result in reduced neonatal development due to the fact that systemic vitamin D status during fetal life depends on maternal concentrations. Some authors reported significant differences in neonatal anthropometric measurements depending on maternal vitamin D concentrations.ObjectiveThe aim of this study is to evaluate the relationship between maternal and cord blood concentrations of vitamin D and neonatal anthropometric measurements at birth.Materials and methodsThis study included 94 pregnant women, at term, who delivered at the Department of Obstetrics, Women’s Diseases and Gynecological Oncology, Medical University of Warsaw. Total serum 25(OH)D concentration was measured in mother–child pairs, and newborn anthropometric data were collected. A multiple regression analysis was used for statistical analysis.ResultsNo relationship between maternal and neonatal cord blood vitamin D concentrations vs. neonatal weight, length, head, and chest circumference at birth was found (p > 0.05). Severe vitamin D deficiency (<10 ng/ml) was detected in 10.6%, deficiency (10–20 ng/ml) in 39.4%, insufficiency (20–30 ng/ml) in 39.4%, and optimal vitamin D concentration (>30 ng/ml) only in 10.6% of the pregnant women. Cord blood vitamin D deficiency (<20 ng/ml) was found in 28.7% of the neonates.ConclusionNo differences between neonatal anthropometric measurements of infants born to mothers with normal and deficient vitamin D concentrations were found.

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Section: Discussionmentioning

confidence: 99%

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

et al. 2018

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“…However, in these two latter studies, analyses were limited to using linear models (8,21,42,43) . Furthermore, another Danish study (44) found a U-shaped association between cord 25(OH)D and birth weight. Multiple causes might explain the inconsistent findings, such as difference in birth period (1981-2002 v. 2010-2012), possible lifestyle changes between 1981 and 2012, sample selection (representative sample v. healthy women), 25(OH)D concentrations (27•2 (SD 18•3) v. 47•0 (SD 21•7) nmol/l) and methodological differences (DBS v. cord blood; adjustment for different confounders; residual confounding).…”

Section: Birth Weight and Ponderal Indexmentioning

confidence: 92%

“…Multivariate linear regression analyses of the association between 25-hydroxyvitamin D 3 (25(OH)D 3 ) concentration (nmol/l) and gestational age at birth in weeks among a random sample of infants born at term (weeks[37][38][39][40][41][42][43][44] in the years between 1981 and 2002 in Denmark (n 2686)* (Coefficients with their standard errors and 95 % confidence intervals)…”

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confidence: 99%

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

et al. 2018

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Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002. There was an inverse association between 25(OH)D3 concentration and gestational age at birth of -0·006 (95 % CI -0·009, -0·003, P<0·001) weeks of gestation per 1 nmol/l increase in 25(OH)D3 concentration. An inverted U-shaped association between 25(OH)D3 and birth weight and Ponderal Index (P=0·04) was found, but no association with size for gestational age was shown. This study suggests that neonatal 25(OH)D3 concentration is associated with anthropometric measures at birth known to be correlated with many subsequent health outcomes such as obesity and type 2 diabetes.

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“…Therefore, we investigated the association between serum 25-(OH)D concentration and WAZ and BAZ. Interestingly, we found a positive correlation between serum 25-(OH)D concentration and BAZ after adjusting for covariates, although some studies reported similar results [ 35 , 36 ]. An explanation for this finding is that BAZ is not a good representative of obesity in school-age children.…”

Section: Discussionmentioning

confidence: 50%

High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

et al. 2018

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Despite the importance of vitamin D in early stages of life, data are lacking on the levels of vitamin D intake and serum 25-hydroxyvitamin D (25-(OH)D) among Chinese school-age children. The aims of this study were to investigate the vitamin D intake and serum 25-(OH)D concentration of children aged 7 to 12 years in China, and to measure the associations between vitamin D status and children’s growth and development parameters. We obtained data on vitamin D intake, serum 25-(OH)D concentration, and anthropometric measurements from a cross-sectional study on school-aged children in China. Multiple linear regression and multivariable logistic regression analyses assessed the associations mentioned above. A total of 563 children (9.5 ± 1.6 years) from six areas of China were included. Among them, 86.1% had a vitamin D intake below the recommended nutrient intake (10 μg/day), and 54.7% had vitamin D deficiency (serum 25-(OH)D <15 ng/mL). We also found that high vitamin D intake was inversely associated with the risk of vitamin D deficiency (OR = 0.836, 95% confidence interval: 0.713, 0.980), and serum 25-(OH)D concentration was positively associated with the intelligence score and body mass index-for-age Z-score (BAZ) (p < 0.05). Insufficient vitamin D intake and serum 25-(OH)D are prevalent among Chinese school-aged children. A negative association was observed between vitamin D intake and the risk of vitamin D deficiency. Moreover, vitamin D status was positively associated with intelligence and BAZ, which await confirmation in future studies.

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Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort

Cited by 21 publications

References 23 publications

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

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