Vitamin D supplementation affects the IGF system in men after acute exercise

Darr, Rachel L.; Savage, Kathleen; Baker, Mark; Wilding, Gregory E.; Raswalsky, Amy; Rideout, Todd C; Browne, Richard W.; Horvath, Peter J.

doi:10.1016/j.ghir.2016.11.002

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Documented presence of vitamin D receptors (VDR) in almost all tissues and organs has prompted intense research into vitamin D effects on regulatory adaptive changes. A merge of vitamin D and acute exercise has recently been proposed to modify the insulin growth factor system for enriched muscle well-being (Darr et al 2016). Consequently, vitamin D is considered to be beneficial in treating sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

et al. 2017

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Mechanisms underpinning age-related decreases in muscle strength and muscle mass relate to chronic inflammation. Physical activity induces an anti-inflammatory effect, but it is modulated by additional factors. We hypothesized that vitamin D, which has also anti-inflammatory activity will modify adaptation to exercise and reduce inflammation in elderly women. Twenty-seven women aged 67 ± 8 years were included and divided into groups with baseline vitamin D concentration more than 20 ng mL−1 (MVD) and less than 20 ng mL−1 (LVD). Both groups performed 1 h Nordic Walking (NW) training combined with vitamin D supplementation for 12 weeks. Serum concentrations of inflammation markers, branched amino acids, vitamin D, muscle strength and balance were assessed at the baseline and three days after intervention. The training caused the significant decrease in concentration of pro-inflammatory proteins HMGB1 (30 ± 156%; 90% CI) and IL-6 (−10 ± 66%; 90% CI) in MVD group. This effects in group MVD were moderate, indicating vitamin D as one of the modifiers of these exercise-induced changes. Rise of myokine irisin induced by exercise correlated inversely with HMGB1 and the correlation was more pronounced at the baseline as well as after training among MVD participants. Although the intervention caused the leucine level to rise, a comparison of the recorded response between groups and the adjusted effect indicated that the effect was 20% lower in the LVD group. Overall the applied training program was effective in reducing HMGB1 concentration. This drop was accompanied by the rise of myokine irisin and better uptake of leucine among women with higher baseline vitamin D.

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Section: Introductionmentioning

confidence: 99%

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

et al. 2017

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“…[45] Vitamin D-mediated enhanced delivery of insulin-like growth factor to the muscles is another proposed mechanism for the effect of vitamin D on muscular performance. [46] Notwithstanding, the beneficial effect of vitamin D on athletic performance may be related to the vitamin D isoform as a research group found that 6 weeks vitamin D 2 (ergocalciferol) supplementation in National Association for Stock Car Auto Racing pit crew athletes not only decreased serum concentrations of 25(OH) D 3 by 21% but resulted in augmented muscular damage biomarkers, as well. [47]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Vitamin D supplementation in physical performance of Iranian elite athletes

et al. 2019

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Background: There has been no report of the vitamin D status of the professional athletes from Iran to date. This study was performed to evaluate the efficacy of weekly vitamin D supplementation on athletic performance in Iranian athletes expedited to Asian competition in Taipei, China, 2015. Methods: This study was a randomized controlled clinical trial. Seventy subjects were enrolled in the study. The athletes were randomly divided into two groups: vitamin D supplement (D; received 50,000 IU of vitamin D supplement weekly) and control (P, received a placebo weekly). Duration of the study was 8 weeks. Anthropometric, dietary, athletic performance, and biochemical evaluations were performed for all subjects in the beginning and in the end of the intervention period. Results: A significant rise in circulating 25(OH)D concentration was observed in D group (17.3 ± 16.9 ng/mL, P < 0.001), whereas in P group, there was a statistically significant decrement (−3.1 ± 8.4 ng/mL, P = 0.040). There were no either within- or between-group significant differences in Ergo jump, vertical jump, and agility tests. In strength leg press tests, both groups showed a significant improvement. However, comparisons of changes revealed that the improvement in D group was significantly higher than in P group ( P = 0.034). Moreover, in sprint test (one repetition-Max, 1RM), only D group had a significant within-group improvement ( P = 0.030). Conclusions: Weekly supplementation with 50,000 IU vitamin D resulted in nearly 17 ng/mL increment in circulating calcidiol. This increase was associated with significant improvement of power leg press and sprint tests in D-supplemented group.

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“…Vitamin D deficiency has been related to muscle weakness and to Insulin Like Growth Factor Binding Protein3 (IGFBP3). A Vitamin D and acute exercise merge is proposed to modify the IGF system [93] The Insulin-Like Growth Factor (IGF) system has implications in physical activity and exercise [94], and more recently in its relationship to Vitamin D. Physical activity alone is correlated with decreases in disease, as are sufficient levels of Vitamin D [95]. Its adequacy may sustain performance ability.…”

Section: Vitamin D Concentration and Sportmentioning

confidence: 99%

Vitamin D concentration effect in health care and sport performance

Georgieva¹,

Żołądkiewicz

Żukow

2018

PPS

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http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. AbstractThe molecular structure of Vitamin D is closely allied to that of classical steroids such as cholesterol. Technically Vitamin D is a seco-steroid hormone. Vitamin D3 (cholecalciferol) is normally produced by exposure to sunlight of the precursor (7-dehydrocholesterol), present in the skin. Vitamin D supplementation vary between 200 IU to 1000 IU. Serum levels of 25(OH)D are generally consider as a indicator of Vitamin D status.Vitamin D plays an essential role in healthcare, related not only with developing and maintaining a healthy skeleton. Its adequate supplementation reduce even the risk of caries and oral infections. Furthermore Vitamin D as a steroid hormone, modulates many gene transcription and has anti-inflammatory and cardiovascular protective effect. Uncertainly low serum levels of 25(OH)D are associated with misbalance in lipid profile and dyslipidemia, sacropenia and muscle weakness. Its insufficiency is also a risk factor for enhanced reception of pain, risk of type 2 diabetes, and often falls occurrences.Adequate Vitamin D status is protective against musculoskeletal disorders, infection disease, depression, diabetes mellitus, autoimmune diseases and neurocognitive dysfunctions.In sport activities and athletic population adequate serum levels of 25(OH)D increase muscle strength, and physical performance, and should be monitored.

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Vitamin D supplementation affects the IGF system in men after acute exercise

Cited by 8 publications

References 40 publications

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

Efficacy of Vitamin D supplementation in physical performance of Iranian elite athletes

Vitamin D concentration effect in health care and sport performance

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