Vitamin D status in primary hyperparathyroidism in India

Harinarayan, CV; Gupta, Nidhi; Kochupillai, N.

doi:10.1111/j.1365-2265.1995.tb02043.x

Cited by 135 publications

(124 citation statements)

References 21 publications

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“…In 1973, Hodgkin first published data regarding vitamin D deficiency [10]. Between 1995 and 2000, studies from north India proved the deficiency of vitamin D in our population [11,12].Subsequently south Indian studies also confirmed it [13][14][15][16].…”

Section: Introductionmentioning

confidence: 81%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglycerides, HDLc, fasting insulin, parathyroid hormone, calcium, albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r = -0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.

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Section: Introductionmentioning

confidence: 81%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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“…Diagnosis is made in symptomatic patients following investigations as seen in studies by Biyabani, [9] Younes, [13] Norris [16] and Bhansali [10]. Vit Defi ciency found in endemic area of some developing countries aggravates the osteitis fi brosa cystic and other related disorder in PHPT [4,14]. Male : female ratio described in literature is 1:2 or 1:3, [2,6,7,11,15,16] in western world, while in our series as also in other series in India and other oriental countries male /female ratio is 1:4 or more [9,4,5,14,17] .The disease appears to present at a comparatively young age (below 40 years) in India and eastern countries.…”

Section: Discussionmentioning

confidence: 99%

“…A large study of primary hyperthyroidism at Mayo clinic of 10 years follow up failed to answer if surgery is necessary in asymptomatic patients [13]. Symptomatic PHPT is still the predominant form of the disease in developing countries [4,5,6,14]. Clinical presentation of skeletal manifestation, abdominal pain, renal calculi with urinary symptoms, gastrointestinal and cardiac symptoms, anxiety, depression and sleeplessness are found in various percentage in PHPT.…”

Section: Discussionmentioning

confidence: 99%

Primary hyperparathyroidism: retrospective 10-year study of 32 cases

2008

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Background Parathyroid glands are endocrine glands that regulate calcium metabolism. Usually four in number, they lie mostly on the posterior aspect of thyroid glands. Primary hyper-parathyroidism (PHPT) refers to a condition wherein they secrete an excess of parathyroid hormone leading to signs and symptoms of hypercalcemia.Patients and Methods Thirty-two patients of primary hyper-parathyroidism were seen by us in the ten years. Majority of patients were below 40 years of age (88%). Male: female ratio was 1:4. The diagnosis was made incidentally in patients who reported for various signs and symptoms not responding to treatment. High serum calcium pointed to the diagnosis of primary parathyroid hyperplasia. It was confi rmed by high level of serum parathyroid hormone and localization of enlarged parathyroid glands by USG / MRI and / or Tc-99 Technetium scan. Of the 32 patients examined, 43 parathyroid glands were excised, fi ve cases had two glands excised; out of these 4 cases underwent parathyroid reimplantation in neck/forearm muscles. One unusual case underwent operation for giant-cell tumor of the head of humerus. This patient presented with excessive vomiting not responding standard medical management in post-operative period.Results During investigations serum calcium was found to be very high, the diagnosis was confi rmed by fi nding high parathyroid hormone and corroborated by T 99 Technetium scan. Parathyroidectomy was done in all cases, of which 59% (18 cases) developed mild to severe tetany due to hypocalcaemia.Conclusion Primary hyperplasia of thyroid gland is the most important cause of hypercalcemia. Hypercalcemia is found in all cases of PHPT in our series with high parathyroid hormone levels. Majority of our cases have one gland involvement and hypocalcaemia in our series is unusually high following excision of involved gland.

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“…The high incidence of bone disease in patients with PHPT in developing countries has been attributed to associated vitamin D and dietary calcium deficiency (Harinarayan, 1995). The various classical clinical features are summed up in [ Table 2].…”

Section: Symptomatic Phptmentioning

confidence: 99%

Management of Primary Hyperparathyroidism: 'Past, Present and Future'

Zachariah¹

2012

Thyroid and Parathyroid Diseases - New Insights Into Some Old and Some New Issues

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Vitamin D status in primary hyperparathyroidism in India

Cited by 135 publications

References 21 publications

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

Primary hyperparathyroidism: retrospective 10-year study of 32 cases

Management of Primary Hyperparathyroidism: 'Past, Present and Future'

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