Vitamin D Status in Children with Autism Spectrum Disorders: Determinants and Effects of the Response to Probiotic Supplementation

Guiducci, Letizia; Vassalle, Cristina; Prosperi, Margherita; Santocchi, Elisa; Morales, Maria Aurora; Muratori, Filippo; Calderoni, Sara

doi:10.3390/metabo12070611

Cited by 3 publications

(5 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First reports on the possibility of using vitamin D to treat autism originate from 2014 when vitamin D was administered intramuscularly and orally to a three-yearold boy with ASD. A significant improvement in his health was noticed after increasing the vitamin level [5,22]. Further research has shown that vitamin D supplementation may relieve ASD symptoms [15] in about 75% of autistic children.…”

Section: State Of the Knowledgementioning

confidence: 95%

“…A relationship between the neurological symptoms and gastrointestinal problems associated with nutritional deficiencies, including (25(OH)D) deficiency, has been frequently frequently observed in ASD in the scientific literature. [22].…”

Section: State Of the Knowledgementioning

confidence: 99%

“…Other peripheral markers of inflammation, e.g. IL-1β, IL-6 or TNF-α, have also been found to be elevated in children with ASD [20,22]. Vitamin D has pro-apoptotic and anti-proliferative properties and participates in neuronal differentiation [8,21], it also indirectly affects the expression of protein Nrf2 and the anti-aging protein Klotho, both of which are also important regulators of many cell signalling systems.…”

Section: State Of the Knowledgementioning

confidence: 99%

See 2 more Smart Citations

Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

Szumna,

Mitas,

Bartos

et al. 2023

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction and Objective. Both autism and vitamin D deficiency are increasingly prevalent among children. Vitamin D is believed to play a key role in many developmental pathways. The aim of this study is to review current knowledge of the relationship between autism spectrum disease and vitamin D deficiency among the paediatric population. Review Methods. The review was performed using the PubMed and Cochrane database from the last 10 years. The terms 'autism' and 'vitamin D deficiency' were searched for. There were 15 articles in English on the PubMed database, 14 were included in the review. In the Cochrane database they were 16 position, 9 of which were included in the final analysis. Brief description of the state of knowledge. Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Typical signs are limited social relations, communication disorder and stereotyped and repetitive behaviours of varying severity. The etiology is still unknown, but nowadays the role of vitamin D deficiency isbeing investigated as a possible risk factor for ASD. There are many scientific reports of the mechanisms of action of vitamin D on the nervous system, as well as on the immune system and all cellular processes, which focus mainly on the regulation of calcium-depending systems, and antioxidant pathways. Vitamin D deficiency during pregnancy and early childhood can significantly affect the developing brain, predisposing to diseases such as autism and schizophrenia. Summary. Further research is still needed to determine the real impact of vitamin D deficiency on the risk of neurodevelopmental disorders, as well as the possibility of using supplementation as a form of treatment.

show abstract

Section: State Of the Knowledgementioning

confidence: 95%

Section: State Of the Knowledgementioning

confidence: 99%

Section: State Of the Knowledgementioning

confidence: 99%

See 1 more Smart Citation

Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

Szumna,

Mitas,

Bartos

et al. 2023

J Pre Clin Clin Res.

View full text Add to dashboard Cite

show abstract

“…Prior studies have linked ASD to Vitamin D deficiency during pregnancy and early childhood 12,13,39 . The underlying molecular mechanisms remain poorly understood, but a key role for neurotransmitter metabolism has been recently suggested 13,39 .…”

Section: Reconstructing Patient-specific Metabolic Network Through Li...mentioning

confidence: 99%

“…Metaanalyses have also identified a series of environmental risk factors, including pre-natal, perinatal, and post-natal elements 5,6,10 . Among these factors, vitamin D has been increasingly implicated in ASD pathogenesis [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

The metabolic role of vitamin D in children’s neurodevelopment: a network study

Marzio

Lasky‐Su

Chu

et al. 2023

Preprint

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with various proposed environmental risk factors and a rapidly increasing prevalence. Mounting evidence suggests a potential role of vitamin D deficiency in ASD pathogenesis, though causal mechanisms remain largely unknown. Here, we investigate the impact of vitamin D on child neurodevelopment through an integrative network approach that combines metabolomic profiles, clinical traits, and neurodevelopmental data from a pediatric cohort. Our results show that vitamin D deficiency is associated with changes in the metabolic networks of tryptophan, linoleic, and fatty acid metabolism. These changes correlate with distinct ASD-related outcomes, including delayed communication skills and respiratory dysfunctions. Additionally, our analysis suggests the kynurenine and serotonin sub-pathways might mediate the effect of vitamin D on early childhood communication development. Altogether, our findings provide metabolome-wide insights into the potential of vitamin D as a therapeutic option for ASD and other communication disorders.

show abstract