Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study

Karagüzel, Gülay; Sakarya, Nil P.; Bahadir, Sevgi; Yaman, Serap Ozer; Ökten, Ayşenur

doi:10.1016/j.clnesp.2016.05.006

Cited by 23 publications

(19 citation statements)

References 21 publications

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“…Vitiligo can involve every part of the skin but usually it appears in the exposed areas, and many patients cover their vitiligo. Some studies have reported the low levels of some elements such as zinc and vitamin D levels and their possible role in the disease pathogenesis (3,4,11).…”

Section: Introductionmentioning

confidence: 99%

Zinc, vitamin D and TSH levels in vitiligo patients

Saniee¹

2019

Erciyes Med J

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Objective: Vitiligo is an acquired depigmenting autoimmune disorder of the skin. The disease association with autoimmune diseases, such as thyroid diseases, has been reported. Previous studies among patients with vitiligo have suggested possible correlation between zinc and vitamin D levels with conflicting results. Here we compared the thyroid hormones, zinc, and vitamin D levels in patients with vitiligo with normal healthy subjects. Materials and Methods: We recruited 98 patients with vitiligo and 98 age-and sex-matched healthy subjects visiting dermatology clinics during spring and summer 2017. Serum zinc and vitamin D levels as well as thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (anti-TPO) were measured and compared between groups. Results: Patients with vitiligo had significantly lower zinc (p=0.01) and higher anti-TPO levels (p=0.02) with no difference in vitamin D (p=0.73) and TSH levels (p=0.31). Patients with vitiligo had also significantly higher rate of increased TSH (p=0.02) and positive anti-TPO (p=0.01). We observed no significant correlation between serum levels of vitamin D, zinc, and TSH with age, gender, and disease duration in patients with vitiligo. Conclusion: Patients with vitiligo, compared to healthy subjects, had lower serum zinc levels, but not vitamin D levels. Increased TSH levels were higher in patients with vitiligo with non-significantly higher anti-TPO AB as suggested to be related to autoimmune disease.

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Section: Introductionmentioning

confidence: 99%

Zinc, vitamin D and TSH levels in vitiligo patients

Saniee¹

2019

Erciyes Med J

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“…Although there have been several studies about pediatric vitiligo in Korea, China, India, the United States, and Kuwait, only one study was done in Turkey in 2016 [1,4,[6][7][8][9][10][11][12][13]. To our knowledge, this was the first study that separately compared serum vitamin D levels in girls and boys with vitiligo.…”

Section: Discussionmentioning

confidence: 99%

“…Vitiligo is a pigmentary disorder caused by autoimmune destruction of melanocytes [1]. Vitiligo affects about 0.5-2% of people worldwide, with half of the cases of vitiligo beginning under the age of 18, mostly in females [2].…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin d levels in children with vitiligo

Manav¹

2020

Ann Clin Anal Med

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Aim: In this study, we aimed to investigate the clinical profile of pediatric vitiligo in Turkey by analyzing differences in gender, clinical features, triggering factors, age of onset, duration of disease, atopy, familial history, and sun exposure in order to report the serum vitamin D levels of children with vitiligo. Material and Method: During a six-month period, 39 children with vitiligo and 39 healthy controls were studied. Demographic details were noted, and dermatological examination was performed to note the areas involved, leukotrichia, and halo nevus. 25-OH vitamin D was carried out by chemiluminescent enzyme immunoassay. Results: The group of girls with vitiligo was compared for serum 25-OH vitamin D levels. Significant differences were found between the girls in the control group, even if there were no significant differences between the group of boys with vitiligo and the control group. There were statistically significant differences in 25-OH vitamin D levels between the groups of girls and boys with vitiligo. Only 12 children had a history of more than 15 minutes of sunshine exposure per day, and a significant difference was noted among the boys. Vitamin D deficiency and insufficiency was found in 20 (5%) and 46 (1%) of children, respectively. Discussion: The antioxidant properties of vitamin D show protection from vitiligo. The low levels of vitamin D in girls with vitiligo are caused by concealing clothing, no daily supplementation of vitamin D, exposure to sunlight, more indoor work, and dark skin. These factors may contribute to the pathogenesis of vitiligo. Keywords Children; Vitamin D; Vitiligo | The Annals of Clinical and Analytical Medicine Vitamin D levels in pediatric vitiligo

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“…

Theoretically, vitamin D plays roles in vitiligo pathogenesis through the following mechanisms: (a) proliferation and differentiation of the immune cells and modulation of immune activities; (b) association of its decreased serum levels with increased risk of autoimmune diseases; (c) increasing size of melanocytes, number and length of their dendrites, levels of tyrosinase, and melanin synthesis; and (d) increasing serum calcium which has role in pathogenesis of vitiligo, per se.

…”

mentioning

confidence: 99%

“…Vitiligo is an autoimmune skin pigmentary disorder with loss of the melanocytes in the epidermis (Karag€ uzel, Sakarya, Bahadır, Yaman, & € Okten, 2016). Its frequent association with other autoimmune disorders and other factors including skin infiltration by T lymphocytes, the presence of anti-melanocyte autoantibodies, and increased expression of type-1 cytokine profiles show the significance of autoimmunity in its pathogenesis.…”

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confidence: 99%

Vitamin D supplementation for vitiligo

Bagherani¹,

Smoller

Lotti

2017

Dermatologic Therapy

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Vitiligo is an autoimmune skin pigmentary disorder with loss of the melanocytes in the epidermis (Karag€ uzel, Sakarya, Bahadır, Yaman, & € Okten, 2016). Its frequent association with other autoimmune disorders and other factors including skin infiltration by T lymphocytes, the presence of anti-melanocyte autoantibodies, and increased expression of type-1 cytokine profiles show the significance of autoimmunity in its pathogenesis.Theoretically, vitamin D plays roles in vitiligo pathogenesis through the following mechanisms: (a) proliferation and differentiation of the immune cells and modulation of immune activities; (b) association of its decreased serum levels with increased risk of autoimmune diseases; (c) increasing size of melanocytes, number and length of their dendrites, levels of tyrosinase, and melanin synthesis; and (d) increasing serum calcium which has role in pathogenesis of vitiligo, per se. The efficacy of topical vitamin D analogs in treating vitiligo has been shown in several studies but the efficacy of vitamin D supplements for treating vitiliginous children has not yet been assessed. For the first time, Karag€ uzel et al. studied the efficacy of oral vitamin D in treating vitiligo in children. They assessed the serum vitamin D level in children with vitiligo in comparison with a control group and then the efficacy of oral vitamin D in treating vitiligo during 6 months. The evaluation of serum vitamin D in two groups showed no statistically significant difference prior to intervention. The authors prescribed topical tacrolimus as monotherapy for cases with normal serum vitamin D level and combination of topical tacrolimus and oral vitamin D for subjects with decreased levels. The study showed a statistically significant improvement of vitiligo in cases under combination therapy. The authors concluded that vitamin D could be a useful supplement in combination with other therapeutic options for treating vitiligo. They suggested that the amount of vitamin D needed for regulating immune system and cell homeostasis is different from the amount needed for preventing vitamin D deficiency.However, more robust clinical trials with big number of subjects is needed to confirm these findings precisely. COM M EN TVitamin D can be an effective supplement in combination with other therapeutic options for treating vitiligo. ORCID Nooshin Bagherani

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Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study

Cited by 23 publications

References 21 publications

Zinc, vitamin D and TSH levels in vitiligo patients

Zinc, vitamin D and TSH levels in vitiligo patients

Serum vitamin d levels in children with vitiligo

Vitamin D supplementation for vitiligo

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