Vitamin D receptor polymorphism FokI is associated with spontaneous idiopathic preterm birth in an Israeli population

Manzon, Licia; Altarescu, Gheona; Tevet, Aharon; Schimmel, Michael S.; Elstein, Deborah; Samueloff, Arnon; Grisaru‐Granovsky, Sorina

doi:10.1016/j.ejogrb.2014.03.008

Cited by 28 publications

(35 citation statements)

References 40 publications

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“…The ORs for the other variants such as Taq1, Bsm1 or Apa1 were insignificant. In contrast to our study, multiple haplotype combinations were not analyzed in the study of Manzon et al because of a limited number of samples -only 33 samples in the preterm birth group [5].…”

Section: Discussionmentioning

confidence: 68%

“…Maternal risk of pre-eclampsia, gestation diabetes and infectious diseases has been related with low levels of maternal circulating 25(OH)D in a number of observational studies [2][3][4]. Few reports indicating an effect of vitamin D or vitamin D receptor polymorphisms on the duration of pregnancy have been published so far [5][6][7]. Spontaneous preterm birth remains a s clinical diagnosis that encompasses many diseases of multiple etiologies.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Baczyńska-Strzecha

Kalinka

2016

Ginekol Pol

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Objectives: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy.The aim of this study was to evaluate the association between the parturients' Apa1, Taq1, and Bsm1 polymorphisms of the VDR and their combinations and the risk of preterm birth in the Polish population. Material and methods:Determination of polymorphism for VDR was assayed using the RT-PCR method. 199 Caucasian women at childbirth were qualified:100 patients who had a spontaneous preterm birth and 99 patients who had a term birth.Results: Three separate genotypes of the Apa1, Taq1, and Bsm1 polymorphisms were detected. No significant differences in the frequency of particular genotypes in the compared groups were found. Some of the genotype combinations were significantly more frequent in the preterm group -the bb/AA/TT genotype (28.0% vs. 10.1%; p = 0.0013) and the BB/aa/tt genotype (14.0% vs. 4.04% p = 0.0277). The Bb/AA/Tt and the BB/Aa/tt genotypes were found only in the control group (16.1% and 7.0% of patients, respectively). The bb/aa/TT was significantly more frequent in the control group (2.0% vs. 11.1%; p = 0,0207). Two genotype combinations reduced the risk of preterm birth -the Bb/AA/Tt genotype by 94% (OR = 0.43, 95% CI: 0.002-0.885, p = 0.041) and the BB/Aa/tt genotype by 98% (OR = 0.029, 95% CI: 0.001-0.838, p = 0.039). Conclusions:Our result suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth. Further research is needed in order to substantiate this finding.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Baczyńska-Strzecha

Kalinka

2016

Ginekol Pol

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“…Therefore, VDR FokI gene polymorphism showed an association with the occurrence of PTB in studied population. Spontaneous idiopathic PTB in an Israeli population was associated with FokI polymorphism in VDR receptor [15].…”

Section: Patel Et Almentioning

confidence: 96%

“…VDR gene expression in placenta regulates various genes linked with implantation, maturity of fetus, and bone formation. Vitamin D status may influence intrauterine skeletal mineralization and growth during pregnancy [15]. VDR gene polymorphism may affect its expression, activity and subsequently downstream biological activity of vitamin D. Therefore, it could be a potent genetic marker for prematurity in pregnant women [16].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor (Vdr) Gene Polymorphism and Maternal Vitamin D Deficiency in Indian Women With Preterm Birth (Ptb)

Patel

Patel²,

Sodagar³

2017

Asian J Pharm Clin Res

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Objective: Preterm birth (PTB) is the leading cause of high infant mortality and long-term disability in young children worldwide. Array of adverse maternal and fetal outcomes linked with vitamin D level and its associated vitamin D receptor (VDR) gene. We undertook this study to investigate the association between VDR gene polymorphism with vitamin D deficiency and PTB in West Indian pregnant women.Methods: A total of 72 women with PTB and 138 healthy mothers with uncomplicated normal delivery were selected from different regions of Gujarat, India. FokI and TaqI single nucleotide polymorphism (SNP) of VDR gene determined by polymerase chain reaction and restriction fragment length polymorphism. Vitamin D level was determined using enzyme-linked immunosorbent assay.Result: ff genotype (29.17% vs. 10.87%, p=0.002) and f allele (49.31% vs. 35.51%, p=0.006) frequency distributions of VDR FokI showed significantly (odds ratio=0.566, 95% confidence interval=0.368-0.870, p=0.006) higher in women with preterm delivery than in control full term group. Genotype frequency of VDR TaqI showed no significant difference between preterm group and control. Conclusion:These results confirmed that women carrying ff genotype of FokI gene had significantly higher risk for vitamin D deficiency which enhances the risk of prematurity than women carrying FF genotype in West Indian women.

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“…The presumed causality between a genetic manipulation and a resulting phenotype should be reconsidered in regards to potential confounding by [193][194][195][196]. (B) Maternal gene dysfunction can impact on the placenta and the embryonic/ fetal environment by altering decidual function [181,182,[197][198][199]. (C) Maternal gene dysfunction may alter weaning behavior and lactation performance and thus influence the early postnatal environment [200][201][202][203].…”

Section: Interaction Of Parental Genes Parental Environment and Fetamentioning

confidence: 99%

Developmental Origins of Disease - Crisis Precipitates Change

Reichetzeder

Putra

et al. 2016

Cell Physiol Biochem

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The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.

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Vitamin D receptor polymorphism FokI is associated with spontaneous idiopathic preterm birth in an Israeli population

Cited by 28 publications

References 40 publications

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population

Vitamin D Receptor (Vdr) Gene Polymorphism and Maternal Vitamin D Deficiency in Indian Women With Preterm Birth (Ptb)

Developmental Origins of Disease - Crisis Precipitates Change

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