Vitamin D receptor gene polymorphism and susceptibility to asthma

Makoui, Masoud Hassanzadeh; Imani, Danyal; Motallebnezhad, Morteza; Azimi, Maryam; Razi, Bahman

doi:10.1016/j.anai.2019.10.014

Cited by 31 publications

(27 citation statements)

References 39 publications

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“…In contrast, FokI SNP is located in the start codon resulting protein with shorter size, the shorter form of the protein (424 amino acids) is more active than the long form (427 amino acids) [15,16]. Over the course of past few decades, the VDR gene polymorphisms have been associated with susceptibility to numerous autoimmune disorders [17][18][19]. In recent years, several studies have investigated the association between VDR gene SNPs and T1DM in all over the world which yielded conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Zhai¹,

Bidares

Makoui

et al. 2020

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Background: The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM. Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to March 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in African and American populations, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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Section: Introductionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Zhai¹,

Bidares

Makoui

et al. 2020

Preprint

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“…In the scientific community, genetic vulnerability to asthma is one of the main research interests [3]. In the recent decade, many studies have been focused to elucidate the susceptibility genes of asthma and several single nucleotide polymorphisms (SNPs) in these genes have been described to be related with asthma risk in different populations [4,5]. Among different genes, interleukin 4 (IL-4) gene has been comprehensively investigated [6,7].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

Imani

Eslami

Sarab

et al. 2020

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Background Previous studies evaluate an association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association between the two. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods An exhaustive search in web of science, Scopus, and PubMed databases was performed to identify all relevant publications before November 2019, and 24 studies with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran Q and the I2 statistics were used to evaluated the degree of heterogeneity between studiesResults In the overall study populations, the result illustrated that IL-4 C33T polymorphism was a risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 SNP (C33T) and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. In the Asian population, there was a significant association between IL-4 SNP (C33T) and risk of asthma under recessive and allelic models. Finally, there was a significant association between IL-4 SNP (C33T) and asthma risk in Caucasian under recessive model and allelic model.Conclusions This study suggests that IL-4 C33T single nucleotide polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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“…Vitamin D (VitD) is a steroid molecule which has many roles in the body, one of which is regulating the immune cells. In addition to immune responses, VitD is also involved in cancer, autoimmune disorders, cardiovascular disorders, asthma, and diabetes [6][7][8]. In animal model of T1DM, VitD suppresses the occurrence of diabetes, by regulating the T helper (Th) 1/Th2 cytokine balance in the local pancreatic lesion [9,10].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Makoui

Aslani

Mohammadi

et al. 2020

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Objective The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of Type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to July 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted.Results A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI genes polymorphism and T1DM in African and American populations, respectively.Conclusions This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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Vitamin D receptor gene polymorphism and susceptibility to asthma

Cited by 31 publications

References 39 publications

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

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