Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus : A North Indian study

Bid, Hemant K.; Konwar, Rituraj; Aggarwal, CG; Gautam, Sunaina; Saxena, M. C.; Nayak, V. Lakshma; Banerjee, Monisha

doi:10.4103/0019-5359.53164

Cited by 118 publications

(53 citation statements)

References 38 publications

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“…Simultaneous companion of autoimmune diseases and diabetes may double the risk of osteoporosis in these patients (10). In addition to influencing the pathophysiology on bone diseases caused by diabetes, bone density disorder in type 1 DM is also influenced by genetic factors (11). Also, increasing risk of fractures has been reported in diabetic patients treated with insulin drugs than non-insulin drugs (12).…”

Section: Introductionmentioning

confidence: 99%

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

et al. 2017

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Background: Type 1 Diabetes mellitus (DM) causes changes in bone mineral density (BMD). Objectives: The aim of this study was to evaluate BMD in children with type 1 DM and predictive factors of BMD loss in these patients. Methods: This cross-sectional study was conducted on 112 children with type 1 DM referrtd to children's medical center in Tehran, Iran during 2015 and 2016. Serum levels of hemoglobin A1c (HbA1c), Insulin-like growth factor 1 (IGF-1), 25-hydroxy vitamin D (25(OH) D), calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphates (ALP), Fasting blood sugar (FBS) was recorded. Lumbar

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Section: Introductionmentioning

confidence: 99%

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

et al. 2017

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“…A study conducted in Asian population by Li et al (2013), suggested that there might be a correlation between polymorphisms at the FokI site and onset of T2DM. A study in North Indian population conducted by Bid et al (2009), was aimed at analyzing association between polymorphisms of VDR gene and genetic predisposition to T2DM. They evaluated SNPs of FokI (T/C) [rs2228570], BsmI (A/G) [rs1544410] and TaqI (C/T) [rs731236] using PCR-RFLP technique similar to this study, but did not find any significant association between the polymorphisms at any of the sites studied between patients and controls.…”

Section: Discussionmentioning

confidence: 99%

“…Fasting glucose was measured photometrically according to the manufacture's instructions using the Dimension Vista ® System (Siemens AG, Erlangen, Germany). Vitamin D Total (VitD) was measured by ADVIA Centaur ®immunoassay System (Siemens, USA) (Bid et al, 2009). …”

Section: Blood Biochemistry Analysesmentioning

confidence: 99%

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Association of Apa I polymorphism of vitamin d receptor gene with type 2 diabetes mellitus in Saudi population

Iyer¹,

New²,

Khoja³

et al. 2017

JEBAS

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KEYWORDS VDR ApaI ABSTRACTVitamin D deficiency has been associated with the acceleration of the onset of T2DM. The biological effects of vitamin D are mediated by binding to the vitamin D receptor (VDR) which belongs to the steroid receptor superfamily. Although many polymorphisms exist in the VDR gene, their effect on VDR protein function and signalling is unknown. An association between VDR polymorphism and T2DM has been reported in some studies; however, it appears to vary across different populations around the world. Hence this study was carried out to investigate the relationship between VDR gene polymorphisms at three restriction sites ApaI, BsmI, and TaqI and the risk of T2DM in Saudi population. The volunteers were classified according to Fasting Blood Glucose (FBG) test as two groups, T2DM and normal group. The VDR gene was amplified by polymerase chain reaction (PCR). PCR products were digested using restriction enzymes: ApaI, TaqI, and BsmI and the bands were visualised by agarose gel electrophoresis and ethidium bromide dye under UV. The results of the current study showed a significant difference in genotypes and allele frequencies of the VDR gene polymorphisms at the ApaI site between T2DM patients and control groups.

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“…In contrast to this result, the present study clearly indicates a role of the recessive t allele in development of GDM. Bid et al (2009) performed a study on the same sites on an Indian population and did not report any association between the VDR gene polymorphism and type II diabetes. The fact that there are discrepancies between various studies could be attributed to the variation in gene pool among various ethnic groups in the VDR gene loci.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

Iyer¹,

New²,

Khoja³

et al. 2017

JEBAS

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Vitamin D is primarily associated with a major role in bone formation. It is also associated with onset and progniosis of diseases such as diabetes, cancer and cardiovascular diseases. In Saudi Arabia, the prevalence of DM is one of the highest reported in the world. There is accumulating evidence suggesting an association between the DM and vit D deficiency. This study was proposed to establish a possible correlation between gestational diabetes mellitus (GDM) and the polymorphisms in the vitamin D receptor (VDR) gene at the sites namely TaqI, BsmI, and ApaI. Results of this study revealed that homozygous recessive genotype tt of the TaqI site with GDM. This study will help to establish the role of VDR gene in occurrence of various subsets of DM which is a major metabolic disorder in Saudi Arabia.

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Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus : A North Indian study

Abstract: BACKGROUND:The vitamin D receptor (VDR)

Cited by 118 publications

References 38 publications

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

Association of Apa I polymorphism of vitamin d receptor gene with type 2 diabetes mellitus in Saudi population

Association of vitamin D receptor gene polymorphisms and gestational diabetes in Saudi Women

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