Vitamin D Metabolism Revised: Fall of Dogmas

Bouillon, Roger; Bikle, Daniel

doi:10.1002/jbmr.3884

Cited by 76 publications

(53 citation statements)

References 115 publications

(181 reference statements)

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“…Macrophages' CYP27B1 is stimulated by interferon-γ (INFγ), tumor necrosis factor α (TNFα), interleukin (IL) 1, 2 and 15, but not by PTH. Moreover, dexamethasone inhibits CYP27B1 [55]. In addition to macrophages, also dendritic cells (DC), Th lymphocytes and B lymphocytes express CYP27B1, but only when they are activated.…”

Section: (Oh) 2 D and The Case For Vitamin D Immunobiologymentioning

confidence: 99%

“…In these cells 1,25(OH) 2 D functions as a 1αhydroxylase inhibitor, thus controlling their activation and proliferation. As described further in details in paragraph 6, 1,25(OH) 2 D exerts many autocrine and paracrine functions on immune system cells, ensuring a feedback control on immune cells themselves [55]. Beyond classical renal CYP27B1 modulation, the novelty in the field is represented by a completely different regulation of CYP27B1 in the other tissues, particularly in the immune system.…”

Section: (Oh) 2 D and The Case For Vitamin D Immunobiologymentioning

confidence: 99%

See 1 more Smart Citation

An Update on Vitamin D Metabolism

Saponaro

Saba

Zucchi

2020

IJMS

192

150

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Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effects will be here summarized, focusing on the immune system and cardiovascular system.

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Section: (Oh) 2 D and The Case For Vitamin D Immunobiologymentioning

confidence: 99%

Section: (Oh) 2 D and The Case For Vitamin D Immunobiologymentioning

confidence: 99%

An Update on Vitamin D Metabolism

Saponaro

Saba

Zucchi

2020

IJMS

192

150

View full text Add to dashboard Cite

show abstract

“…Correction of vitamin D deficiency is relatively easy by either increased exposure to sunlight (unlikely for patients with ARDS), oral or parental vitamin D supplementation, or supplementation with 25OHD (calcifediol). To correct vitamin D deficiency in severely sick patients much higher doses than usual are needed [81], probably related to impaired hepatic conversion of vitamin D into 25OHD [82]. Calcifediol may have some advantages over the native vitamin D: it has a more reliable intestinal absorption (close to 100 %) and can rapidly restore serum concentrations of 25OHD as it does not require hepatic 25-hydroxylation.…”

Section: Clinical Consequences: Vitamin D Status and Adrs During Coromentioning

confidence: 99%

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

Quesada‐Gómez

Castillo

Bouillon

2020

The Journal of Steroid Biochemistry and Molecular Biology

Self Cite

139

170

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…VDR is expressed in more than 30 target tissues in humans [11], and a genome-wide analysis revealed more than 1000 VDR-specific genomic binding sites in most tissues, suggesting that the transcriptionally active form of vitamin D influences the expression of many genes likely to be relevant for human health and disease [12]. Furthermore, lessons from VDR and CYP27B1 null mice indicate that VDR may act either dependently or independently of 1,25(OH) 2 D. Thus, multiple receptors and ligands may participate in the vitamin D endocrine system [1,3,13], in addition to non-genomic actions via unclear mechanisms [14][15][16]. Indeed, consistent with the multiple biological functions of the active form of vitamin D, there is evidence that VDR, which is normally localized in the nucleus and associated with gene transcription, may also be present in the plasma membrane and mediate rapid responses to 1,25(OH) 2 D [11,17].…”

Section: Sources Metabolism and Pleiotropic Functions Of Vitamin Dmentioning

confidence: 99%

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

Kim

Perrelli

Ragni³

et al. 2020

Antioxidants

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Vitamin D deficiency has been clearly linked to major chronic diseases associated with oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative diseases, diabetes, and cancer. In particular, the cardiovascular system appears to be highly sensitive to vitamin D deficiency, as this may result in endothelial dysfunction and vascular defects via multiple mechanisms. Accordingly, recent research developments have led to the proposal that pharmacological interventions targeting either vitamin D deficiency or its key downstream effects, including defective autophagy and abnormal pro-oxidant and pro-inflammatory responses, may be able to limit the onset and severity of major cerebrovascular diseases, such as stroke and cerebrovascular malformations. Here we review the available evidence supporting the role of vitamin D in preventing or limiting the development of these cerebrovascular diseases, which are leading causes of disability and death all over the world.

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Vitamin D Metabolism Revised: Fall of Dogmas

Cited by 76 publications

References 115 publications

An Update on Vitamin D Metabolism

An Update on Vitamin D Metabolism

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

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