Vitamin D level regulates serum lipids discrepantly in adults with and without dyslipidemia

Abstract

Vitamin D deficiency is associated with hyperlipidemia, but it remains unclear whether vitamin D supplementation reduces serum lipid levels. The aims of this study were to investigate the associations between increased serum 25-hydroxyvitamin D (25(OH)D) concentrations and lipid levels, and identify the characteristics of people with or without lipid reduction associated with increased 25(OH)D levels. The medical records of 118 individuals (53 men; mean age, 54.4 ± 10.6 years) whose serum 25(OH)D levels increased between two consecutive measurements were retrospectively reviewed. People with increased 25(OH)D levels (from 22.7 (17.6–29.2) to 32.1 (25.6–36.8) mg/dL; P < 0.01) had a significant reduction in serum levels of triglycerides (TG) (from 111.0 (80–164) to 104.5 (73–142) mg/dL; P < 0.01) and total cholesterol (TC) (from 187.5 (155–213) to 181.0 (150–210) mg/dL; P < 0.05). The individuals who responded to vitamin D (≥10% reduction in TG or TC levels) exhibited significantly higher baseline TG and TC levels than did those who did not. Only patients with hyperlipidemia (not those without hyperlipidemia) at baseline exhibited significantly reduced TG and TC levels at follow-up. However, increasing serum 25(OH)D concentrations were significantly correlated with decreasing lipid levels in individuals with baseline 25(OH)D levels less than 30 ng/mL, and in individuals aged 50–65 years (not in patients younger than 50 years or older than 65 years). In conclusion, increasing serum 25(OH)D concentrations may be potentially helpful for the treatment of hyperlipidemia in people with vitamin D deficiency.

Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

“…HDL-C was lower and TGs were higher in the hypovitaminosis D group [ 21 ]. Similar positive associations have been observed in numerous other studies conducted across various populations [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. A recent cross-sectional study confirmed that the percentage of individuals with dyslipidemia and dysglycemia was higher in subjects with low levels of vitamin D [ 33 ].…”

Analysis of dietary fats intake and lipid profile in Chilean patients with glucose transport type 1 deficiency syndrome: similarities and differences with the reviewed literature

“…Regarding vitamin D intake, the GLUT1-DS group received an average supplementation of 660 IU/day to complete the recommended requirements according to age and gender. Although there are no studies that evaluate the effect of supplementation in subjects similar to those in our study, evidence suggests that deficiency of this vitamin may be related to a higher risk of dyslipidemia, and correcting it could be beneficial for individual health, especially among adults (22,23).…”

A novel LC-MS/MS method combined with derivatization for simultaneous quantification of vitamin D metabolites in human serum with diabetes as well as hyperlipidemia

“…It was reported that vitamin D deficiency is associated with hyperlipidemia, and elevated human serum 25OHD levels were associated with decreased human serum TC and TG levels, especially in patients with hyperlipidemia who were vitamin D deficiency. 14 Therefore, increasing the concentration of circulating 25OHD may be used as an adjunct therapy for hyperlipidemia. 14 It has a certain reference value for clinical diagnosis and treatment.…”

“…14 Therefore, increasing the concentration of circulating 25OHD may be used as an adjunct therapy for hyperlipidemia. 14 It has a certain reference value for clinical diagnosis and treatment.…”

“…8,9 Especially, a growing number of studies have also found a strong link between vitamin D deficiency and diabetes and hyperlipidemia. 10–14 Vitamin D has no biological activity and needs to be converted into bioactive metabolites through two steps of hydroxylation. 15,16 The biotransformation pathway of vitamin D and the related metabolites is demonstrated in Fig.…”