2022
DOI: 10.3390/nu14030505
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Abstract: In the last 2 years, observational studies have shown that a low 25-hydroxyvitamin D (25(OH)D) level affected the severity of infection with the novel coronavirus (COVID-19). This study aimed to analyze the potential effect of vitamin D supplementation in reducing SARS-CoV-2 infection morbidity and severity in health care workers. Of 128 health care workers, 91 (consisting of 38 medical doctors (42%), 38 nurses (42%), and 15 medical attendants (16%)) were randomized into two groups receiving vitamin D suppleme… Show more

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Cited by 19 publications
(17 citation statements)
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“…Furthermore, considering the mechanism of SARS-CoV-2 transmission, it also important to highlight that amino acids can improve mucosal surface defense by stimulating IgA secretion [ 25 ]. Amino acids may modulate immune response, enhancing immune cell energy sources, the CD4+, CD4+/CD8+ ratio, intestinal immunoglobulin, innate and adaptive immune response, pro-inflammatory cytokines, and dendritic cell function [ 26 , 27 ]. Even though we have no measurements regarding the composition of the intestinal microbiome, in light of the correlation between the amino acid pool and the proper functioning of the immune system, it is reasonable to suggest the achievement of the correct amino acid intake, also through oral supplementation, in COVID-19 survivors.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, considering the mechanism of SARS-CoV-2 transmission, it also important to highlight that amino acids can improve mucosal surface defense by stimulating IgA secretion [ 25 ]. Amino acids may modulate immune response, enhancing immune cell energy sources, the CD4+, CD4+/CD8+ ratio, intestinal immunoglobulin, innate and adaptive immune response, pro-inflammatory cytokines, and dendritic cell function [ 26 , 27 ]. Even though we have no measurements regarding the composition of the intestinal microbiome, in light of the correlation between the amino acid pool and the proper functioning of the immune system, it is reasonable to suggest the achievement of the correct amino acid intake, also through oral supplementation, in COVID-19 survivors.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, plasma concentrations of 25-hydroxyvitamin D above 30 ng/mL are associated with lesser risk for cardiovascular disease and all-cause mortality rate, pointing out that vitamin D supplementation is the most efficient way to accomplish these concentrations [ 36 ]. In this context, a randomized controlled trial carried out on health workers with the aim of analyzing the reduction in the severity of COVID-19 according to the dose of vitamin D3 (cholecalciferol) supplementation for three months showed the need for high doses of supplementation [ 37 ]. Thus, only subjects receiving higher supplementation doses (5000 IU/day) showed normalization of circulating levels of 25-hydroxy vitamin D, a lower tendency to suffer from COVID-19, and a higher propensity for asymptomatic disease [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this context, a randomized controlled trial carried out on health workers with the aim of analyzing the reduction in the severity of COVID-19 according to the dose of vitamin D3 (cholecalciferol) supplementation for three months showed the need for high doses of supplementation [ 37 ]. Thus, only subjects receiving higher supplementation doses (5000 IU/day) showed normalization of circulating levels of 25-hydroxy vitamin D, a lower tendency to suffer from COVID-19, and a higher propensity for asymptomatic disease [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…To date, only 11 randomized controlled trials assessing the effect of therapeutic vitamin D supplementation on COVID-19 patients have been published; however, the role of vitamin D in disease severity remains controversial ( 42 , 74 83 ). Most of these trials showed beneficial effects on a reduction in inflammatory markers, improvements in immune function, SARS-CoV-2 viral clearance, recovery of symptoms, and reductions in the severity of the disease and in-hospital mortality ( 42 , 74 , 75 , 77 80 ). Nevertheless, other studies demonstrated contradictory data that vitamin D supplementation did not improve inflammatory markers or reduce the length of hospital stay, admission to the intensive care unit or mortality ( 76 , 81 83 ).…”
Section: Effect Of Vitamin D Supplementation On Covid-19mentioning
confidence: 99%