Vitamin D Improves the Glycemic Control, Inflammation, Oxidative Stress and related miRNA Expression in Type 2 Diabetes Mellitus: A Randomized Placebo- Controlled Trial

Mahjabeen, Wajiha; Khan, Dilshad Ahmed; Mirza, Shakil Ahmed

doi:10.1016/j.metabol.2020.154531

Cited by 1 publication

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“…Further, anti-inflammatory, insulin-sensitizing adipokines, such as adiponectin, are notably absent in individuals with overweight and diabetes [ 67 , 72 ]. Of note, previous authors have not only linked serum adiponectin with VitD status, but have also shown improvement following supplementation [ 73 , 74 , 75 , 76 ]. In this way, inflammation is secondary to excess adiposity in the context of obesity, and T2DM is associated with VitD status; importantly, it may also improve these markers with supplementation.…”

Section: Type 2 Oxidative Stress and Autoimmunitymentioning

confidence: 99%

Clarifying the Heterogeneity in Response to Vitamin D in the Development, Prevention, and Treatment of Type 2 Diabetes Mellitus: A Narrative Review

Hands

Corr

Peterson

2023

IJERPH

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In this review, we explore the potential drivers of heterogeneity in response to Vitamin D (VitD) therapy, such as bioavailability, sex-specific response, and autoimmune pathology, in those at risk for and diagnosed with T2DM. In addition, we propose distinct populations for future interventions with VitD. The literature concerning VitD supplementation in the prevention, treatment, and remission of type 2 diabetes mellitus (T2DM) spans decades, is complex, and is often contradictory with mixed findings upon intervention. By association, VitD status is powerfully predictive with deficient subjects reporting greater risk for T2DM, conversion to T2DM from prediabetes, and enhanced response to VitD therapy. Preclinical models strongly favor intervention with VitD owing to the pleiotropic influence of VitD on multiple systems. Additional research is crucial as there remain many questions unanswered that are related to VitD status and conditions such as T2DM. Future research must be conducted to better understand the potentially spurious relationships between VitD status, supplementation, sun exposure, health behaviors, and the diagnosis and management of T2DM. Public health practice can greatly benefit from a better understanding of the mechanisms by which we can reliably increase VitD status and how this can be used to develop education and improve health behaviors.

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