Vitamin D effects in atopic dermatitis

Samochocki, Zbigniew; Bogaczewicz, Jarosław; Jeziorkowska, Renata; Sysa-Jędrzejowska, Anna; Glińska, Olga; Karczmarewicz, Elżbieta; McCauliffe, Daniel P.; Woźniacka, Anna

doi:10.1016/j.jaad.2013.03.014

Cited by 92 publications

(84 citation statements)

References 30 publications

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“…Studies have also shown that VD receptor agonists inhibit the production of IgE in cultured human B cells and allergic mice models [50]. However, in our study, we found no correlation between IgE levels and VD levels in either atopic or non-atopic AD, consistent with the results of other studies [31, 32]. Unexpectedly, we found that the absolute eosinophil count in peripheral blood was negatively correlated with serum levels of VD and VA.…”

Section: Discussionsupporting

confidence: 91%

“…Although the majority of previous studies have indicated that there is an inverse relationship between serum VD levels and the severity of AD, overall, their results have not been consistent. Samochocki et al [32] found that the mean serum concentration of 25(OH)D3 was not significantly different between patients with AD and control subjects. Studies by Chiu et al [33] and Han et al[34] showed that although VD levels were lower in AD patients than in HCs, there was no correlation between VD levels and AD.…”

Section: Discussionmentioning

confidence: 99%

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Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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“…It was found that vitamin D deficiency may probably be responsible for the most intensive skin lesions localized on body regions not exposed to sun. 22 Not all interventional studies proved the clinical effect of vitamin D supplementation on AD. In Hata and colleagues' 23 study, mentioned previously, the vitamin D levels were measured before and after the 21-day follow-up supplementation of 4000 IU vitamin D. The results showed no change in the mean EASI score following supplementation.…”

Section: The Relationship Between Vitamin D Supplementation and The Amentioning

confidence: 99%

The Role of Vitamin D in Atopic Dermatitis

et al. 2015

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Vitamin D has been suggested to have an important impact on a much wider aspects on human health than calcium homeostasis and mineral metabolism, specifically in the field of human immunology. It has been reported that vitamin D influences the regulation of both innate and adaptive immune systems, which makes the association between vitamin D and allergic diseases a field of interest. Although many studies have sought to determine whether vitamin D has an influence on progression of allergic disease, the impact of vitamin D on atopic dermatitis development and severity remains unclear. In this review, we summarize recent studies relating vitamin D to atopic dermatitis and discuss its possible role in the pathogenesis of allergic skin diseases, emphasizing the need for well-designed, prospective trials on vitamin D supplementation in the context of prevention and treatment for allergic conditions.

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“…Clinical studies indicate that oral vitamin D supplements dramatically ameliorate the severity of atopic dermatitis. [35,36] Eczema arises from a combination of factors compromising both the epidermal barrier and the expression of antimicrobial peptides. A VDR agonist was reported to mobilize Foxp3-expressing regulatory T cells in mice.…”

Section: Role Of Vitamin D In Their Progression and Treatmentmentioning

confidence: 99%

Immunological Role of Vitamin D in Skin Diseases and Carcinoma

Yuan¹,

Madu²,

Lu³

2017

Oncomedicine

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Growing evidence attests to the vital role vitamin D plays in the dynamics of the immune system. Active 1,25(OH)2D3 binds to the vitamin D receptor (VDR) to form a ligand-activated receptor complex able to control transcription in the nucleus. We examined the various mechanisms through which vitamin D3 alters and enhances immune responses in a variety of skin conditions, as well as the pathways it activates to inhibit the progression of tumors and carcinomas. The hormone primarily elicits a change as either an inflammation modulator or cancer suppressor. Also addressed are current advancements in vitamin D treatment methods through the development of novel analogs.

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Vitamin D effects in atopic dermatitis

Cited by 92 publications

References 30 publications

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

The Role of Vitamin D in Atopic Dermatitis

Immunological Role of Vitamin D in Skin Diseases and Carcinoma

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