Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients

Abstract

1,25(OH)2D3 and EB 1089 inhibit PBMC proliferation, induce apoptosis in PBMC of healthy subjects and IBD patients, and affect ICAM-1 expression on PBMC and on HUVEC cocultured with PBMC, suggesting that the ICAM-1 downregulation could provide a new target for controlling the recruitment of leukocytes at the sites of inflammation in IBD.

Anti-inflammatory effect of 1α,25-dihydroxyvitamin D3 in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease

“…More recently, it has been reported that vitamin D may be used as a therapeutic option to treat inflammatory diseases, including Behç et's disease, inflammatory bowel disease, multiple sclerosis, experimental sepsis and inflammatory polyarthritis [27][28][29][30][31][32][33]. IVIG therapy has been reported to be effective for reducing the incidence of coronary artery lesions in KD patients [34][35][36].…”

Differential expression of leukocyte functions associated antigen-1 (LFA-1) on peripheral blood mononuclear cells in patients with Crohnʼs disease

“…TNF-a has been shown to enhance LFA-1 expression 22 and IFX has been shown to reduce expression of the ligand of LFA-1 (ICAM-1) and CD40 ligands on T cells. [23][24][25] Because IFX suppresses activated effector cells through apoptosis or antibody-dependent cytotoxicity, 26 the decrease in LFA-1 expression found in our investigation seems to be a consequence of a decrease in the number of activated T cells and leukocytes that express LFA-1. It is well known that among the subsets of T cells, LFA-1 expression is increased in CD4þ and CD8þ T cells in patients with CD.…”

Influence of Adding Pyrroloquinoline Quinone to Parenteral Nutrition on Gut‐Associated Lymphoid Tissue

“…22,23 Parenterally fed animals show significantly less MAdCAM-1 expression and messenger RNA in PP. 38,39 Because some vitamins reportedly alter gene expression of adhesion molecules, 40,41 PQQ might also have upregulated MAdCAM-1 expression on PP endothelial cells. In contrast, PN does not induce depletion of MAdCAM-1 expression in the small intestine except in PP.…”