Vitamin D Deficiency Reduces the Immune Response, Phagocytosis Rate, and Intracellular Killing Rate of Microglial Cells

Djukic, Marija; Onken, Marie Luise; Schütze, Sandra; Redlich, Sandra; Götz, Alexander; Hanisch, Uwe‐Karsten; Bertsch, Thomas; Ribes, Sandra; Hanenberg, Andrea; Schneider, S.; Bollheimer, Cornelius; Sieber, Cornel; Nau, Roland

doi:10.1128/iai.01814-14

Cited by 42 publications

(33 citation statements)

References 58 publications

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“…Vitamin D supplementation with high, compared with standard doses had a mild anti-inflammatory effect, but did not further increase the resistance of the brain against infections [155,156].…”

Section: Vitaminsmentioning

confidence: 98%

Bacterial meningitis: an update of new treatment options

Nau

Djukic

Spreer

et al. 2015

Expert Review of Anti-infective Therapy

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The outcome of bacterial meningitis critically depends on the rapid initiation of bactericidal antibiotic therapy and adequate management of septic shock. In community-acquired meningitis, the choice of an optimum initial empirical antibiotic regimen depends on the regional resistance patterns. Pathogens resistant to antibacterials prevail in nosocomial bacterial meningitis. Dexamethasone is recommended as adjunctive therapy for community-acquired meningitis in developed countries. In comatose patients, aggressive measures to lower intracranial pressure <20 mmHg (in particular, external ventriculostomy, osmotherapy and temporary hyperventilation) were effective in a case-control study. Although many experimental approaches were protective in animal models, none of them has been proven effective in patients. Antibiotics, which are bactericidal but do not lyse bacteria, and inhibitors of matrix metalloproteinases or complement factor C5 appear the most promising therapeutic options. At present, vaccination is the most efficient method to reduce disease burden. Palmitoylethanolamide appears promising to enhance the resistance of the brain to infections.

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Section: Vitaminsmentioning

confidence: 98%

Bacterial meningitis: an update of new treatment options

Nau

Djukic

Spreer

et al. 2015

Expert Review of Anti-infective Therapy

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“…In addition, antigen presenting cells convert vitamin D to 1,25(OH) 2 VD 3 , a physiologically active form of vitamin D that is highly concentrated in lymphoid tissues (Mora, Iwata et al 2008) where it can modulate function of T and B cells which express vitamin D receptors. Vitamin D deficiency results in reduced differentiation, phagocytosis and oxidative burst, by monocytes as well as defective bactericidal activity by keratinocytes (Fabri, Stenger et al 2011, Djukic, Onken et al 2014). …”

Section: Modulation Of Immunity By Nutritional Change In Audmentioning

confidence: 99%

Opposing effects of alcohol on the immune system

Barr

Helms

Grant

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

179

121

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Several studies have described a dose-dependent effect of alcohol on human health with light to moderate drinkers having a lower risk of all-cause mortality than abstainers, while heavy drinkers are at the highest risk. In the case of the immune system, moderate alcohol consumption is associated with reduced inflammation and improved responses to vaccination, while chronic heavy drinking is associated with a decreased frequency of lymphocytes and increased risk of both bacterial and viral infections. However, the mechanisms by which alcohol exerts a dose-dependent effect on the immune system remain poorly understood due to a lack of systematic studies that examine the effect of multiple doses and different time courses. This review will summarize our current understanding of the impact of moderate versus excessive alcohol consumption on the innate and adaptive branches of the immune system derived from both in vitro as well as in vivo studies carried out in humans and animal model studies.

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“…However, co-treatment of THP-1 cells with ATP and 1,25(OH) 2 D 3 resulted in more IL-1b secretion than ATP or 1,25(OH) 2 D 3 alone. V itamin D 3 or 1,25-dihydroxy-vitamin D 3 (1,25(OH) 2 D 3 ), is most well known for its role in calcium and phosphate metabolism [Norman, 2006] but has gained recent attention both in the scientific literature and popular media for its emerging role in immunity and inflammatory diseases [Prietl et al, 2013;Djukic et al, 2014;Wang et al, 2014]. Active vitamin D 3 , (i.e, 1,25(OH) 2 D 3 ) is formed by a 3-step process [Wikvall, 2001;Henry, 2011].…”

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confidence: 99%

Vitamin D₃Metabolites Enhance the NLRP3-Dependent Secretion of IL-1β From Human THP-1 Monocytic Cells

et al. 2015

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Vitamin D3 has emerged as an important regulator of the immune system. With metabolic enzymes for vitamin D3 activation and vitamin D receptors (VDR) now identified in a variety of immune cells, the active vitamin D3 metabolite 1,25(OH)2D3, is thought to possess immunomodulatory properties. We examined whether 1,25(OH)2D3 might also enhance the NLRP3-dependent release of mature IL-1β from macrophages. PMA-differentiated THP-1 cells were stimulated with vitamin D3 metabolites and assessed for CYP27, CYP24, NLRP3, ASC, pro-caspase-1 expression by western blot and real-time qPCR as well as inflammasome activation with pro-inflammatory cytokine IL-1β release measured by ELISA. Exposure to 1,25(OH)2D3 had no effect on the basal expression levels of VDR; however, CYP27A1 transcript was suppressed and CYP24A1 transcript was substantively elevated. Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1β release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082. Interestingly, 1,25 (OH)2D3 exposure reduced NLRP3 protein expression but had no effect on ASC or pro-caspase-1 protein levels. The increase in mature IL-1β elicited by 1,25(OH)2D3 was modest compared to that found for ATP or C. difficile toxins. However, co-treatment of THP-1 cells with ATP and 1,25(OH)2D3 resulted in more IL-1β secretion than ATP or 1,25(OH)2D3 alone.

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Vitamin D Deficiency Reduces the Immune Response, Phagocytosis Rate, and Intracellular Killing Rate of Microglial Cells

Cited by 42 publications

References 58 publications

Bacterial meningitis: an update of new treatment options

Bacterial meningitis: an update of new treatment options

Opposing effects of alcohol on the immune system

Vitamin D₃Metabolites Enhance the NLRP3-Dependent Secretion of IL-1β From Human THP-1 Monocytic Cells

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Vitamin D Deficiency Reduces the Immune Response, Phagocytosis Rate, and Intracellular Killing Rate of Microglial Cells

Cited by 42 publications

References 58 publications

Bacterial meningitis: an update of new treatment options

Bacterial meningitis: an update of new treatment options

Opposing effects of alcohol on the immune system

Vitamin D3Metabolites Enhance the NLRP3-Dependent Secretion of IL-1β From Human THP-1 Monocytic Cells

Contact Info

Product

Resources

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Vitamin D₃Metabolites Enhance the NLRP3-Dependent Secretion of IL-1β From Human THP-1 Monocytic Cells