Vitamin D deficiency is associated with greater tumor size and poorer outcome in Merkel cell carcinoma patients

Samimi, Mahtab; Touzé, Antoine; Laude, Hélène; Bidre, Emmanuelle Le; Arnold, Françoise; Carpentier, A.; Gardair, Charlotte; Carlotti, A.; Maubec, Ève; Dupin, Nicolas; Aubin, F.; Avril, Marie-Françoise; Rozenberg, Flore; Avenel-Audran, M.; Guyétant, Serge; Lorette, G.; Machet, L.; Coursaget, Pierre

doi:10.1111/jdv.12101

Cited by 27 publications

(21 citation statements)

References 55 publications

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“…A U-shaped relationship was observed for prediagnostic 25(OH)D and breast cancer mortality in the Swedish Malmo cohort (81). On the basis of blood samples taken after diagnosis, a higher level of 25(OH)D was associated with a lower colorectal cancer mortality (82,83), ovarian cancer mortality (84), and Merkel cell carcinoma mortality (although not significant) (85). Higher postdiagnostic 25(OH)D status was also associated with significantly improved pancreatic cancer survival in 1 study (86).…”

Section: Or In the European Prospective Investigation Into Cancer Andmentioning

confidence: 95%

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Mondul

Weinstein

Layne

et al. 2017

Epidemiologic Reviews

162

133

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There has been substantial enthusiasm recently regarding the potential role of vitamin D in the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of anticarcinogenic effects for vitamin D compounds, but human studies have yielded little consistent evidence supporting a protective association. Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined. Despite there being no official institutional recommendations regarding the use of vitamin D supplements for cancer prevention, screenings for vitamin D deficiency and vitamin D supplement use have increased substantially over the past decade. These widespread practices demonstrate that population sociobehavioral changes are often adopted before scientifically well-informed policies and recommendations are available. This review critically examines the currently available epidemiologic literature regarding the associations between circulating 25(OH)D, vitamin D supplementation, and vitamin D-related genetic variation and cancer risk and mortality, with a particular emphasis on prospective studies. We identify several important gaps in our scientific knowledge that should be addressed in order to provide sufficient reproducible data to inform evidence-based recommendations related to optimal 25(OH)D concentrations (and any role for vitamin D supplementation) for the primary and secondary prevention of cancer. With few exceptions, such recommendations cannot be made at this time.

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Section: Or In the European Prospective Investigation Into Cancer Andmentioning

confidence: 95%

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Mondul

Weinstein

Layne

et al. 2017

Epidemiologic Reviews

162

133

View full text Add to dashboard Cite

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“…A few other studies have investigated the associations of circulating 25-OHD levels with prognosis in patients with other cancers, including lymphoma (15,30), leukemia (31,32), skin (33,34), head-and-neck (35,36), gastric (37), pancreatic (38), and prostate cancers (39, 40) with varying results (Table 4). Elevated 25-OHD levels were associated with better overall survival in patients with gastric cancer and lymphoma.…”

Section: Other Cancersmentioning

confidence: 99%

Circulating 25-hydroxyvitamin D Levels and Prognosis among Cancer Patients: A Systematic Review

Toriola

Nguyen

Scheitler

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Circulating 25-hydroxyvitamin D (25-OHD) is associated with a reduction in risk of some cancers, but its association with prognosis among patients with cancer is poorly understood. In view of the increasing number of cancer survivors in the United States and the high prevalence of vitamin D deficiency among patients with cancer, an evaluation of the role of circulating 25-OHD in prognosis among patients with cancer is essential. We conducted a systematic review of studies published in the following databases-PubMed, OvidSP, BioMed Central, EMBASE, and Scopus till September 2013 using the following search terms: "vitamin D," "25-hydroxyvitamin D," "calcidiol," "cancer," "survival," "mortality," and "prognosis." Our search yielded 1,397 articles. From the 1,397 articles, we identified 26 studies that evaluated the associations of circulating 25-OHD with prognosis among patients with cancer. Evidence suggests that circulating 25-OHD levels may be associated with better prognosis in patients with breast and colorectal cancer, but there is a paucity of information on its association with prognosis in other cancers. This review highlights the need for further studies evaluating the role of vitamin D in prognosis among patients with cancer. Cancer Epidemiol Biomarkers Prev; 23(6); 917-33. Ó2014 AACR.

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“…Diagnosis of MCC had been established between 1998 and 2013. Part of this cohort has previously been described [30,31]. Follow-up was performed as recommended in the French National Guidelines by clinical examination every 3-6 months and by intermittent imaging [lymph node ultrasonography and/or computed tomography (CT) scan] every 6-12 months.…”

Section: Methodsmentioning

confidence: 99%

Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

Gardair¹,

Samimi

Touzé

et al. 2015

Neuroendocrinology

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Background/Aims: Merkel cell carcinoma (MCC) is a rare high-grade neuroendocrine tumour of the skin. It has been speculated that MCCs express somatostatin receptors (SSTRs), but this has never been assessed in a large series of MCCs. The main aim of this study was to assess the expression of SSTR2A and SSTR5 in MCC tumours. The secondary aims were to assess whether expression of SSTR was associated with the Ki67 proliferative index, Merkel cell polyomavirus (MCPyV) status, clinical characteristics and outcome. Methods: Clinical data and tumours were collected from an ongoing cohort of French patients with MCC. Immunohistochemistry was performed with anti-SSTR2A and anti-SSTR5 monoclonal antibodies, and tumours were classified into 3 groups: ‘no expression', ‘low expression' and ‘moderate expression' using an SSTR staining score. Results: SSTR expression was assessed for 105 MCC tissue samples from 98 patients, and clinical characteristics were available for 87 of them. SSTR expression was consistent between the primary skin tumour and the corresponding metastases for SSTR2A and SSTR5 in 3/7 and 6/7 cases, respectively. SSTR2A and SSTR5 were expressed in 58 cases (59.2%) and in 44 cases (44.9%), respectively. Overall, at least one SSTR was expressed in 75 tumours (76.5%). SSTR expression was not associated with clinical characteristics, Ki67 proliferative index, recurrence-free survival or MCC-specific survival. Expression of SSTR2A was associated with MCPyV status in MCC tumours but not SSTR5. Conclusion: SSTRs were expressed in a high proportion of MCCs, although expression was heterogeneous between tumours and was not associated with disease severity.

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Vitamin D deficiency is associated with greater tumor size and poorer outcome in Merkel cell carcinoma patients

Abstract: The association between vitamin D deficiency and MCC characteristics and outcome, together with detection of the VDR in MCC cells, suggest that vitamin D could influence the biology of MCC.

Cited by 27 publications

References 55 publications

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Circulating 25-hydroxyvitamin D Levels and Prognosis among Cancer Patients: A Systematic Review

Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

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