Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin

Norman, A. W.; Frankel, JB; Heldt, A. M.; Grodsky, G M

doi:10.1126/science.6250216

Cited by 652 publications

(384 citation statements)

References 39 publications

Supporting

Mentioning

356

Contrasting

Unclassified

Order By: Relevance

“…Additionally, vitamin D had a significant influence on subsiding of inflammatory process in type 2 diabetes (25). As recent investigations have detected, a severe deficiency of vitamin D suppresses pancreas secretion and insulin circulation which leads to low insulin levels and glucose toleration disorder (26,27). As in the current studies, low vitamin D serum values are associated independently to abdominal obesity and hyperglycemia (28).…”

Section: Discussionsupporting

confidence: 61%

Vitamin D status and its relationship with age in type 2 diabetic patients

Mahmodnia¹,

Tamadon²,

Sadoughi³

et al. 2017

J Parathyr Dis

View full text Add to dashboard Cite

Introduction: Type 2 diabetes has become a chronic worldwide epidemic with advancing complications and has caused many premature deaths. Its global prevalence is about 9.7%, with 92.4 million suffering from the disease. Vitamin D level has been recently considered as an adjustable risk factor of cardiovascular diseases in individuals with type 2 diabetes. Objectives: The aim of the current study is to investigate the frequency of vitamin D deficiency and the relationship between vitamin D serum levels and age in type 2 diabetes patients. Patients and Methods:In this descriptive-analytic study, 101 type 2 diabetes patients of Imam Ali clinic in Shahrekord were investigated. Serum vitamin D levels of the participants were measured by DRG (USA) Elisa kits. The results were analyzed using SPSS software with a 95% confidence level. Results: Of 101 studied patients, 32 were male and 69 were female. The average age of the subjects was 61.25 ± 11.75 years. The average age of the males was 63.09 ± 11.15 years and the average age of the females was 60.39 ± 12 years. Around 72 subjects were vitamin D deficient. No significant difference of vitamin D levels between males and females (P = 0.985) was detected. Serum vitamin D levels of type 2 diabetes patients were significantly positive correlated with their ages (r = 0.282, P = 0.004). Conclusion:In the present study the prevalence of vitamin D deficiency in type 2 diabetes patients was 71.3 %. We found a positive significant relationship between the vitamin D level and age. It is possible that ageing process is not one of the causes of vitamin D deficiency.

show abstract

Section: Discussionsupporting

confidence: 61%

Vitamin D status and its relationship with age in type 2 diabetic patients

Mahmodnia¹,

Tamadon²,

Sadoughi³

et al. 2017

J Parathyr Dis

View full text Add to dashboard Cite

show abstract

“…Although cross-sectional analyses and laboratory experiments suggest that vitamin D deficiency and obesity are associated with the weakened response of cells to insulin, predisposed IR and pancreatic β-cell dysfunction (26,27,(67)(68)(69) , intervention outcomes were not always consistent. Variations may be due to differences in study populations and intervention protocols.…”

Section: Discussionmentioning

confidence: 98%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Design: An intervention trial. Setting: Shenzhen City, Guangdong Province, China. Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.Results: For the survey, there was no significant difference (P > 0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P = 0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P < 0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men. Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. KeywordsVitamin D Obesity Chinese male Parathyroid hormone Insulin resistanceIn China, approximately 12 % of adult males are considered to be obese (1,2) . Since vitamin D nutritional status may be important in regulating obesity (3)(4)(5)(6) , interest was aroused to study Chinese obese males in this regard. Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .In addition, 25(OH)D ≤25 nmol/l (10 ng/ml) is considered to be 'severe vitamin D deficiency', 75-250 nmol/l (30-100 ng/ml) a 'sufficient or optimal' level and 50-75 nmol/l (21-29 ng/ml) an 'insufficient' level (12,13,18) , although these reference ranges are not defined by the Inst...

show abstract

“…Vitamin D repletion improves insulin sensitivity and insulin secretion in animal studies (25). Hypovitaminosis D has been proposed as a risk factor for reduced insulin secretion, impaired glucose tolerance, and type 2 diabetes in adults (23)(24)(25)(26)(27)(28)(29). However, some studies in obese adults demonstrated no relationship between vitamin D, PTH, and insulin sensitivity (30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

177

109

View full text Add to dashboard Cite

Objective: The roles of vitamin D and parathyroid hormone (PTH) are discussed controversially in obesity, and studies of these hormones in obese children are limited. Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children. Methods: Fasting serum PTH, 1,25-OH Vit D, 25-OH Vit D, inorganic phosphate, calcium, alkaline phosphatase (AP), insulin, glucose, and weight status (SDS-BMI and percentage body fat) were determined in 133 obese children (median age 12.1 years) and compared with 23 non-obese children. Furthermore, these parameters were analyzed in 67 obese children before and after participating in a 1-year obesity intervention program. Results: Obese children had significantly (P!0.001) higher PTH and lower 25-OH Vit D concentrations compared with non-obese children, while calcium, phosphate, AP, and 1,25-OH Vit D did not differ significantly. Changes of PTH (rZ0.23, PZ0.031) and 25-OH Vit D (rZK0.27, PZ0.013) correlated significantly with changes of SDS-BMI, but not with changes of insulin sensitivity (homeostasis model assessment; HOMA-B%). Reduction of overweight in 35 children led to a significant (P!0.01) decrease of PTH concentrations and an increase in 25-OH Vit D levels. Conclusions: PTH levels were positively and 25-OH Vit D concentrations were negatively related to weight status. Since these alterations normalized after weight loss, these changes are consequences rather than causes of overweight. A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children. Further longitudinal clamp studies are neccessary to study the relationship between vitamin D and insulin sensitivity. European Journal of Endocrinology 157 225-232Introduction Vitamin D and parathyroid hormone (PTH) are well known for their essential role in bone metabolism and calcium homeostasis. The main sources of vitamin D are ergocalciferol and cholecalciferol, the former normally available in food and the latter produced in the skin by u.v. radiation of 7-dehydrocholesterol. Both of these compounds are hydroxylated in the liver to 25-hydroxyvitamin D (25-OH Vit D), which is the major circulating metabolite precursor to the hormonally active form, 1,25-dihydroxy-vitamin D (1,25-OH Vit D).It has become increasingly clear that the vitamin D endocrine system is related to obesity in adults. Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10, 11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes. In these cell...

show abstract

Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin

Cited by 652 publications

References 39 publications

Vitamin D status and its relationship with age in type 2 diabetic patients

Vitamin D status and its relationship with age in type 2 diabetic patients

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Contact Info

Product

Resources

About