2016
DOI: 10.1371/journal.pone.0162554
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Abstract: BackgroundVitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among children with T1DM and its relationship with insulin sensitivity and glycemic status.Subjects and MethodsA cross sectional study was carried out between 2008–2014. A total of 141 patients had a T1DM >12 months diagnosis and were enrolled in the present study. Of these 35 (24.8%) were migrants and 106 (75.2%) Italians (T2). We retrospecti… Show more

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Cited by 57 publications
(53 citation statements)
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References 44 publications
(56 reference statements)
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“…However, that low levels improved spontaneously after correction of acidosis, the direct contribution of 25-OH D deficiency in the acute presentation of DKA remains controversial (39). Our result was similar to the results of Savastio et al who reported that, children with T1DM show a generalized 25OHD deficiency that impact on metabolic status and glycemic homeostasis and 25OHD levels were inversely related to diabetic ketoacidosis severity (p<0.05) (40).…”
Section: Discussionsupporting
confidence: 88%
“…However, that low levels improved spontaneously after correction of acidosis, the direct contribution of 25-OH D deficiency in the acute presentation of DKA remains controversial (39). Our result was similar to the results of Savastio et al who reported that, children with T1DM show a generalized 25OHD deficiency that impact on metabolic status and glycemic homeostasis and 25OHD levels were inversely related to diabetic ketoacidosis severity (p<0.05) (40).…”
Section: Discussionsupporting
confidence: 88%
“…Nevertheless, in different autoimmune diseases, vitamin D supplementation has been shown to be therapeutically effective, such as Behcet disease, RA, and SLE in adults . Studies on relationship between vitamin D deficiency and pediatric autoimmune disorders such as type 1 diabetes mellitus, systemic lupus erythematosus, thyroiditis, and juvenile dermatomyositis also revealed therapeutic effects of vitamin D supplementation …”
Section: Discussionmentioning
confidence: 99%
“…Recently, many studies have reported associations between vitamin D deficiency and a higher incidence of autoimmune disorders in adults such as RA, SLE, psoriasis, vitiligo, MS, IBD, and Behcet disease . Also, relation of vitamin D deficiency and autoimmune diseases including type 1 diabetes mellitus, systemic lupus erythematosus, autoimmune thyroiditis, and juvenile dermatomyositis has been researched in pediatric population …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A cross-sectional study of 141 T1DM patients and given 1000 IU/day cholecalciferol as supplementation. There was a significant difference in levels of 25(OH)D 3 between subjects with control and found to be a significant increase in levels of 25(OH)D 3 [28].…”
Section: Subject Characteristicsmentioning
confidence: 77%