Vitamin D association with estradiol and progesterone in young women

Knight, Julia A.; Wong, Jody; Blackmore, Kristina M.; Raboud, Janet; Vieth, Reinhold

doi:10.1007/s10552-009-9466-0

Cited by 54 publications

(49 citation statements)

References 16 publications

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“…In particular, we adjusted for the effect of seasonal and latitude effects on 25(OH)D3 synthesis via the date, the center, or the mean daily UV dose for the center at the time of blood collection; in addition, we adjusted for calcium and PTH serum concentrations. We also took into account estradiol and progesterone serum concentrations, which have been reported to be associated with vitamin D status (12,26). Moreover, we controlled for both dietary and supplement intakes.…”

Section: Discussionmentioning

confidence: 99%

“…Among six case-control studies nested in cohorts, only a recent study (20) found a statistically significant inverse association, whereas the others failed to find any association (21)(22)(23)(24)(25). Studies which analyzed data by menopausal status (14,15,17,(20)(21)(22)(23)(24)(25) or age (19,22) suggested that the effect of vitamin D on breast cancer is modulated by the hormonal milieu, a suggestion further supported by the recent finding of an association between circulating 25(OH)D and steroid hormones in young women (26).…”

Section: Introductionmentioning

confidence: 94%

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Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

Engel

Fagherazzi

Boutten

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

123

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Background: High 25-hydroxyvitamin D [25(OH)D] serum concentrations have been found to be associated with reduced breast cancer risk. However, few studies have further investigated this relationship according to menopausal status, nor have they taken into account factors known to influence vitamin D status, such as dietary and serum calcium, parathyroid hormone, and estradiol serum levels.Methods: We designed a nested case-control study within the French E3N cohort. Cases were women diagnosed with incident breast cancer (n = 636). Controls (n = 1,272) were matched with cases on age, menopausal status at blood collection, age at menopause, and center and year of blood collection. Multivariate logistic regression models were established.Results: We found a decreased risk of breast cancer with increasing 25(OH) vitamin D 3 serum concentrations (odds ratio, 0.73; 95% confidence interval, 0.55-0.96; P trend = 0.02) among women in the highest tertile. We also observed a significant inverse association restricted to women under 53 years of age at blood sampling [odds ratio (T 3 versus T 1 ), 0.60; 95% confidence interval, 0.37-0.98; P trend = 0.04]. In premenopausal women, the risk was also decreased, although not significantly.Conclusion: Our findings support a decreased risk of breast cancer associated with high 25(OH) vitamin D 3 serum concentrations, especially in younger women, although we were unable to confirm a direct influence of age or menopausal status.Impact: Randomized intervention trials with vitamin D supplementation are required to confirm its benefits on breast cancer risk, but the maintenance of adequate vitamin D levels should be encouraged by public health policy. Cancer Epidemiol Biomarkers Prev; 19(9); 2341-50. ©2010 AACR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

Engel

Fagherazzi

Boutten

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

123

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“…Serum level of estrogen and progesterone in young women was shown to be inversely related with serum 25-OHD levels [35].…”

Section: Discussionmentioning

confidence: 95%

High Prevalence of Vitamin D Deficiency in Women Presenting to Rheumatology Clinic in North of Iran: An Inverse Relation with Age

Heidari¹,

Heidari²

2013

J Women's Health Care

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“…[81] Decreasing vitamin D 3 levels and increasing ROS with advancing age along with male estrogen levels that are 2-3 times higher than females over the age of 49 might explain why all cancer incidences increase with increasing age and steadily increase with advancing age of males (see Figures 3A and 3B and values in Table 3). Intriguingly, lower levels of vitamin D lead to higher levels of estrogen in a dose dependent manner, [82] so that estrogen might have actually been slowly increasing over recent decades in only developed countries where most people work indoors. Lower cancer incidences in Asians and other populations compared to European populations might be from outdoor work leading to good vitamin D 3 levels and the fact that they primarily synthesize eumelanin (black hair), which absorbs ROS, rather than pheomelanin (red and blond hair) that produces ROS, so that ROS do not activate HPV and cause increased release of its virions.…”

Section: Discussionmentioning

confidence: 99%

All sites but skin cancer incidences analyzed worldwide by sex, age, and skin type over time (1955-2007), advancing age, and UVB dose reveals important carcinogenic drivers

Godar

Gurov²,

Merrill

2017

JER

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Because we observed increasing incidences over time, advancing age, higher estrogen levels, decreasing UVB (290-315 nm) doses, or lower vitamin D3, and Human Papillomavirus hiding in immune-privileged sites of hair follicles play roles in melanoma, we wondered if the majority of cancers might have similar carcinogenic drivers. To investigate this possibility, we performed worldwide analysis of all sites but skin cancer over time , advancing age, and UVB doses for males and females with all skin types and ages (0-85+) and in five age groups using IARC data. To investigate Human Papillomavirus's role, we analyzed the incidences of breast, prostate, and colon cancers in a developed country with European ancestry (New Zealand) having high amounts of androgenic hair and a developing country with Asian ancestry (India) having low amounts of androgenic hair. To potentially add epidemiology to the already established role of estrogen in cancer, we analyzed males and females in various countries around the world using the incidence of breast cancer (> 70 yr.) as an established indicator of estrogen levels. The analysis reveals cancer incidences are steadily increasing over time in developed but not developing countries regardless of skin type. Only US white, but not black, breast, prostate, and colon cancer incidences in the oldest age group significantly decreased with increasing UVB dose suggesting a role for vitamin D3. The data suggests the carcinogenic drivers in many cancers are estrogen, increasing age (or reactive oxygen species), decreasing vitamin D3 levels, and persistence of Human Papillomavirus infection in immune-privileged sites.

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Vitamin D association with estradiol and progesterone in young women

Abstract: Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.

Cited by 54 publications

References 16 publications

Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

High Prevalence of Vitamin D Deficiency in Women Presenting to Rheumatology Clinic in North of Iran: An Inverse Relation with Age

All sites but skin cancer incidences analyzed worldwide by sex, age, and skin type over time (1955-2007), advancing age, and UVB dose reveals important carcinogenic drivers

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