Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women

Vučeljić, Marina; Ilic-Stojanovic, Olivera; Lazović, Milica; Grajic, Mirko

doi:10.2298/vsp1203243v

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…A study carried out in a Danish population showed that elevated plasma calcidiol level was associated with an increased risk of nonmelanoma and melanoma cancer [14]. Low vitamin D levels were also found in postmenopausal women in this region in 88.4% of patients [32]. In the first study from a country with high insolation (Spain), suboptimal vitamin D levels were also found in melanoma patients at diagnosis, but the levels were higher than those reported in the UK study.…”

Section: Discussionmentioning

confidence: 91%

Melanoma risk is associated with vitamin D receptor gene polymorphisms

et al. 2014

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Previous studies have reported that vitamin D receptor (VDR) gene polymorphisms are associated with the occurrence of various cancers, including melanoma. The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels. The study group included 117 patients (84 patients with superficial spreading melanoma and 33 patients with nodular melanoma). The control group included 122 sex-matched and age-matched healthy-blood donors of the same ethnicity. VDR gene polymorphisms FokI, EcoRV, TaqI, and ApaI were genotyped by real-time PCR. In 60 patients, the total 25-hydroxyvitamin D levels were evaluated in serum samples by direct chemiluminescence. Associations among parameters were considered to be significant if the P value was less than 0.05. Significant differences in the frequencies of VDR genotypes were observed between cases and the control group for FokI and TaqI polymorphisms (P<0.0001; P=0.005, respectively). Heterozygous Ff as well as mutant FF genotypes of the FokI polymorphism were associated with increased melanoma risk compared with the wild-type form [odds ratio (OR)=3.035, P=0.003; OR=9.276, P<0.0001, respectively]. A significantly increased melanoma risk was observed for the heterozygous Tt (OR=2.302, P=0.011) and the mutated variant tt (OR=3.697, P=0.003) of the TaqI polymorphism in comparison with the wild-type genotype. None of the polymorphisms studied was associated with clinicopathological characteristics and vitamin D serum level. Our results suggest that FokI and TaqI polymorphisms in the VDR gene may be considered as potential biomarkers for melanoma susceptibility. Low vitamin D levels in melanoma patients indicate the need for vitamin D supplementation.

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Section: Discussionmentioning

confidence: 91%

Melanoma risk is associated with vitamin D receptor gene polymorphisms

et al. 2014

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“…[242526] Few studies have shown a positive correlation of serum 25(OH)D levels and BMD. [20222327] Vitamin D is a fundamental vitamin to maintain calcium level in the bone by increasing calcium absorption in the intestines, stimulating bone resorption by increasing number of osteoclasts, and maintain level of parathyroid hormone to stabilize serum calcium levels. [23]…”

Section: Discussionmentioning

confidence: 99%

Association between serum 25-hydroxyvitamin D levels and bone mineral density in normal postmenopausal women

2016

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Aim:This study was conducted with the objective of assessing serum 25-hydroxyvitamin D (25(OH)D) in postmenopausal women (PMW), to detect osteopenia or osteoporosis in PMW and to establish a correlation between serum 25(OH)D levels and bone mineral density (BMD).Materials and Methods:A total of 100 healthy PMW were selected, and a prospective observational study was conducted to correlate the BMD with serum 25(OH)D levels. Their laboratory investigations along with serum 25(OH)D levels were done. Their BMD was assessed with dual-energy X-ray absorptiometry at lumbar spine and neck of femur; T-scores were derived. Correlation analysis was done to investigate the relationship between serum 25(OH)D levels and BMD.Results:The proportion of osteoporosis at the hip was 31.9% in deficient group, 16.1% in insufficient, and 18.2% in sufficient group and at lumbar spine, it was 27.7%, 16.1%, and 22.7%, respectively. Forty-seven percent of PMW had deficient (<20 ng/ml) serum 25(OH)D levels and 31% had insufficiency. T-score at hip in deficient group was −2.05 ± 0.25, and in an insufficient group, it was −1.79 ± 0.13; T-score at lumbar spine was −1.92 ± 0.12 and −1.79 ± 0.12, respectively, but both were not statistically significant. Osteoporosis was seen in 24%, osteopenia in 55% at hip level and 23% and 59% respectively at lumbar spine. There was no association between serum 25(OH)D levels and BMD neither at hip nor at lumbar spine (P = 0.51 and P = 0.79 respectively).Conclusion:In this study, among our cohort of patients there was no correlation between serum 25(OH)D levels and BMD. However, Vitamin D deficiency coexists with low BMD. Vitamin D insufficiency is a common risk factor for osteoporosis associated with increased bone remodeling and low bone mass.

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All 25-hydroxyvitamin D-deficient Indian postmenopausal women do not have secondary hyperparathyroidism

2018

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Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women

Abstract: Our results showed a high prevalence of vitamin D insufficiency (88.4%) among postmenopausal women. The levels of 25(OH)D and PTH changed significantly according to the season.

Cited by 7 publications

References 31 publications

Melanoma risk is associated with vitamin D receptor gene polymorphisms

Melanoma risk is associated with vitamin D receptor gene polymorphisms

Association between serum 25-hydroxyvitamin D levels and bone mineral density in normal postmenopausal women

All 25-hydroxyvitamin D-deficient Indian postmenopausal women do not have secondary hyperparathyroidism

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