2008
DOI: 10.1210/er.2008-0004
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Abstract: The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VDR). Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital dis… Show more

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Cited by 1,477 publications
(1,342 citation statements)
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References 602 publications
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“…It was also shown that vitamin D exerts direct anti-atherosclerotic effects on endothelial and vascular smooth muscle cells [3,4,51]. Hence, it is conceivable that vitamin D might prevent ischemic myocardial diseases by direct anti-atherosclerotic effects and by beneficial effects on cardiovascular risk factors.…”
Section: Indirect Effects Of Vitamin D On the Myocardiummentioning
confidence: 99%
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“…It was also shown that vitamin D exerts direct anti-atherosclerotic effects on endothelial and vascular smooth muscle cells [3,4,51]. Hence, it is conceivable that vitamin D might prevent ischemic myocardial diseases by direct anti-atherosclerotic effects and by beneficial effects on cardiovascular risk factors.…”
Section: Indirect Effects Of Vitamin D On the Myocardiummentioning
confidence: 99%
“…Given that vitamin D plays an important role for the immune system including resistance to infectious diseases, it could be hypothesized that a sufficient vitamin D status might prevent myocardial diseases by reducing the incidence of infections of the heart [55]. Moreover, the increased prevalence of autoimmune diseases in vitamin D-deficient individuals and the proposed involvement of autoimmunological processes in the development of heart diseases suggest that anti-autoimmunological properties of vitamin D might be another protective mechanism against myocardial diseases [4,56]. systolic function in 1a-hydroxylase knockout mice have been observed [10,58,59].…”
Section: Indirect Effects Of Vitamin D On the Myocardiummentioning
confidence: 99%
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“…In contrast, a similar role of VD3 and VDR in this context is not known. VD3, Cyp27b1 or VDR deficiencies have a myriad of effects on immune cells and other compartments, such as an impaired intestinal epithelial barrier,54 altered calcium homeostasis55 and constant low‐grade inflammation with elevated IL‐6,56 which makes studies of DC biology in these mice problematic due to secondary effects. Future studies with novel genetic tools, single‐cell‐based, or single‐population‐based analyses and corresponding bioinformatics should help to clarify the cell‐specific influence of VD3 on DC in vivo , with possible implications for patients.…”
Section: Vd3 and DC Precursor (Pre‐dc) Derived Dc In The Mousementioning
confidence: 99%
“…PPARG is expressed mainly in fat but also to a lesser extent in muscle and is important for adipogenesis, lipid metabolism, inflammation, and glucose control (Yki-Jarvinen 1995; Zierath et al 1998). Further, VDR/RXR signaling regulates a variety of metabolic pathways together with a variety of immune responses (Bouillon et al 2008). In addition, an animal study showed that mice lacking a functional VDR had reduced insulin secretion and higher blood glucose levels than normal mice (Zeitz et al 2003).…”
Section: Gadd45bmentioning
confidence: 99%