Vitamin D&amp;lt;sub&amp;gt;3&amp;lt;/sub&amp;gt; Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;R Tardive Dyskinesia Mice Model

Bankole, Oluwamolakun O.; Laoye, Babafemi J.; Sirjao, Mujittapha U.; Ishola, Azeez Olakunle; Oyeleke, Damilola E.; Balogun, Wasiu G.; Amin, Abdulbasit; Cobham, Ansa Emmanuel; Akinrinade, Ibukun; Ogundele, Olalekan Michael

doi:10.4236/jbise.2015.88049

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…No statistical significance was observed when vitamin D3 were administered at low dosage (MPTP/Vit.D3 L ) with the control group (NS) and MPTP/L-DOPA. The result from the rotarod test implies that the role of MPTP in motor dysfunction is linked to its effect on the nigrostriatal dopaminergic pathway where it causes DA depletion in the brain (Burns et al, 1983;Langston et al, 1984;Bankole et al, 2015). There were no significant differences in all the groups when compared with the control group (NS) except with the group that received MPTP only as seen in the passive rotation recorded in rotarod test for motor function.…”

Section: Biochemical Assaymentioning

confidence: 97%

“…There was also a statistically significant difference when comparing MPTP/Vit.D3 H to MPTP/Vit.D3 L and MPTP only group. Vitamin D3 intervention shows improvement in motor coordination at high dose (100mg/kg) as it has also been shown to improve motor deficit in another model of Parkinsonism Ishola et al, 2015;Bankole et al, 2015). PD is the most common cause of parkinsonism, accounting for ∼80% of cases and the pathological hallmarks of PD are the loss of the nigrostriatal dopaminergic neurons as well as the presence of intraneuronal proteinacious cytoplasmic inclusions, termed "Lewy Bodies" (LBs) (Dauer and Przedborski, 2003).…”

Section: Biochemical Assaymentioning

confidence: 99%

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Cholecalciferol attenuates induced Parkinson’s like-disease variation and cellular morphology of striatum and substantial Nigra

Adekeye¹,

Adefule²,

Shallie³

et al. 2018

Anat. J. Afr.

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Parkinson’s disease is the commonest motor neurodegenerative disorder which affects the dopaminergic neurons and causes significant loss of dopamine. 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a selective neurotoxin in the nigrostriatal pathway leading to this motor disorder. Cholecalciferol (Vitamin D3) has been described as an active neurosteriod with antioxidant properties ubiquitously present in the brain. The study hypothesized that stimulation of vitamin D receptor by cholecalciferol could reduce autophagic cell death and degeneration following a state of drug induced parkinsonism in mice. The aim of the research was to observe the cytoarchitectural, histochemical, neurobehavioural and immunohistochemical effects of cholecalciferol on striatum and substantia nigra in mice model of MPTP-induced Parkinson’s disease. Fifty adult male C57BL/6J mice weighing about 25-35g were randomly selected and assigned into 5 groups for this study. The mice were then subjected to neurobehavioural, neurochemical and neuropathological evaluations. The results obtained showed a significant reduction (*p<0.05) in the estimated markers of oxidative stress with high dose of vitamin D3 following MPTP induction. There was also statistical significant reduction (**p<0.01, ***p<0.001) in the expression of GFAP-immuno-positive cells in the substantia nigra of the experimental mice when compared with the control group. It can be inferred that the administration of Vitamin D3 was associated with significant attenuation of focal effects linked with MPTP in mice model of Parkinson’s Disease.Keywords: Aging, Neurodegeneration, Dopaminergic neuron, Vitamin D3, Environmental toxins

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Section: Biochemical Assaymentioning

confidence: 97%

Section: Biochemical Assaymentioning

confidence: 99%

Cholecalciferol attenuates induced Parkinson’s like-disease variation and cellular morphology of striatum and substantial Nigra

Adekeye¹,

Adefule²,

Shallie³

et al. 2018

Anat. J. Afr.

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“…Extrapyramidal syndromes (EPS) represent neurological side effects induced by antipsychotic medications, primarily acting on dopamine receptors in the brain [1][2][3][4][5]. These manifestations include movement disorders such as akathisia, dystonia, Parkinsonism, and tardive dyskinesia [5][6][7][8][9]. The dopaminergic system's crucial role in motor function has been extensively documented, with prolonged dopamine receptor inhibition affecting neurons in the primary motor cortex and basal nuclei [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Sirajo,

Maigari,

Sunusi

et al. 2023

Preprint

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Background: Extrapyramidal syndromes (EPS) represent neurological side effects of antipsychotic medications, characterized by motor disturbances. While previous studies have indicated the neuroprotective effects of vitamin D and A against EPS, the underlying mechanisms of this protection remain unclear.Methods: Twenty-four adult male mice were categorized into four groups: positive and negative control groups, one receiving a dopamine antagonist, and the other receiving both a dopamine antagonist and vitamins D and A. Sections of the corticobasal loop, specifically the motor cortex (M1) and basal nuclei (CPu), were prepared for Immunohistochemistry (IHC) and stained with Glial Fibrillary Acidic Protein (GFAP) to visualize active astrocytes. ELISA assays for TNF-α, IL-6, IL-4, IL-13, and dopamine levels were performed on homogenized brain sections.Results: The EPS group exhibited a significant increase in TNF-α and IL-6 levels in M1 and CPu. Treatment with dopamine agonists and vitamin D/A resulted in significant reductions in IL-6 levels. Only the Vitamin D/A group showed a significant decline in TNF-α. The EPS group recorded significant decreases in IL-4 and IL-13, with IL-13 significantly elevated in the dopamine agonist and Vitamin D/A groups. IL-4 was notably increased in the Vitamin D/A groups. Dopamine concentration significantly declined in the EPS group, with improvements observed in the groups treated with dopamine agonists, vitamin D, and A. Reactive astrocytes were significantly expressed in the M1 and CPu of the EPS group but poorly expressed in other regions.Conclusions: EPS is linked to astrocyte activation, an upsurge in pro-inflammatory cytokines, a decline in anti-inflammatory cytokines, and dopamine in the corticobasal loop. Administration of vitamin D3 and A was found to exert its effects by suppressing pro-inflammatory cytokines and repressing anti-inflammatory cytokines associated with astrocyte activation.

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“…The Al was found to accelerate the accumulation of the hallmarks of AD disease called neurofibrillary tangle (Drago et al, 2007;Zaky et al, 2013). Chronic Al accumulation is also intimately linked to numerous other neurodegenerative conditions, including Parkinson's disease, dialyzed encephalopathy, and amyotrophic lateral sclerosis (Azeez et al, 2015;Mujittapha et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effect of Alpha-Lipoic Acid on Aluminium Induced Toxicity in the Prefrontal Cortex and Hippocampus of Wistar Rats

Abdullahi,

Umar,

Dauda

et al. 2023

dujopas

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The aim of the present study was to determine the protective effect of Alpha lipoic acid (ALA) on Aluminum chloride (AlCl3) induced cerebral and hippocampal toxicity in Wistar rat. The experimental design involved 5 groups of 5 rats that were treated with saline, Aluminum chloride and/or Alphalipoic acid; for 2 weeks. At the end of the treatment phase, Morris water maze test was conducted to estimate the spatial memory function before the animals were euthanized and the Prefrontal cortex (PFC) and Hippocampus tissues evaluated. The behavioral studies showed that AlCl3 induces significant decline in spatial memory which was corroborated with histological features of loss of neural density and necrosis of pyramidal cells. Co-exposure of Aluminum with Alpha-lipoic acid was associated with sparing of spatial memory with maintenance of brain structure. The findings from the present study confirms that the structural and functional neurotoxicity of Aluminium can be ameliorated with the concomitant usage of Alpha-lipoic acid during the Aluminum exposure.

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Vitamin D<sub>3</sub> Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D<sub>2</sub>R Tardive Dyskinesia Mice Model

Cited by 9 publications

References 25 publications

Cholecalciferol attenuates induced Parkinson’s like-disease variation and cellular morphology of striatum and substantial Nigra

Cholecalciferol attenuates induced Parkinson’s like-disease variation and cellular morphology of striatum and substantial Nigra

Synergistic Action of Vitamin D3 and A Protects Motor Activity by Regulating Reactive Astrocytes, Inflammatory Cytokines, and Dopaminergic Activity in the Corticobasal Loop of a Mice Model of Extrapyramidal Syndrome

Effect of Alpha-Lipoic Acid on Aluminium Induced Toxicity in the Prefrontal Cortex and Hippocampus of Wistar Rats

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