Vitamin D: A Modulator of Allergic Rhinitis

Agarwal, Sunita; Singh, Suresh; Kumar, R; Sehra, Ritu

doi:10.1007/s12070-019-01697-9

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…5,6 Changes in vitamin D levels in the body can regulate the immune system, and thus affect the occurrence of AR. 7,8 Polymorphisms of the VDR gene (Apa Ⅰ, TaqbI) may affect VDR expression level and are involved in many physiological and pathological processes. 9 Therefore, it is reasonable to assume that VDR gene polymorphisms may influence the occurrence of AR by regulating VDR expression level.…”

Section: Introductionmentioning

confidence: 99%

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Zhang¹,

Xu²

2020

PGPM

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Background: Vitamin D receptor (VDR) gene polymorphisms are involved in a variety of immune-related diseases, and VDR is associated with allergic rhinitis. The present study explored the associations between VDR gene polymorphisms and allergic rhinitis in the Chinese population. Methods: The study population consisted of 400 patients with allergic rhinitis and 400 healthy controls. General characteristics were determined by interview. Blood DNA was extracted and genotyping was performed via matrix-assisted laser desorption/ionization timeof-flight mass spectrometry. The associations of each genetic variant with risk for AR were assessed by calculating the odds ratio (OR) with 95% confidence interval (95% CI). Results: No significant differences were observed in general characteristics between cases and controls. The distributions of genotypes at the rs2228570 locus of the VDR gene conformed to Hardy-Weinberg equilibrium. There was a significant difference in the distribution of rs2228570 genotype (P<0.001) between cases and controls. Compared to GG and GA genotypes, the AA genotype increased the risk of AR (OR=3.27, 95% CI: 2.10-5.11, P=0.000; OR=2.58, 95% CI:1.63-4.08, P<0.001). Similar results were also observed in the dominant model (OR=1.64, 95% CI:1.24-2.17, P<0.001) and codominant model (OR=2.95, 95% CI:1.93-4.51, P<0.001). The A allele was still associated with elevated risk gene for AR after adjusting for potential confounding factors. Subgroup analyses indicated an interaction between alcohol and rs2228570 in the risk of allergic rhinitis. The A allele also increased the risk for AR in the population without asthma (OR=1.85, 95% CI:1.46-2.34, P<0.001). Conclusion: VDR gene polymorphism is associated with AR, and the AA genotype of rs2228570 is associated with the increased risk of AR in the Chinese population.

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Section: Introductionmentioning

confidence: 99%

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Zhang¹,

Xu²

2020

PGPM

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“…For example, Joudi et al 21 found that the vitamin D level was a predictive factor for efficacy of subcutaneous allergen immunotherapy, but the study included only 55 AR patients. Agarwal et al 7 found that vitamin D supplementation relieved nasal symptoms, but the study had a small sample size (n = 80). More importantly, residual confounding (such as sunlight exposure, diet and latitude) should always be borne in mind when interpreting observational results.…”

Section: Discussionmentioning

confidence: 94%

“…The evidence from epidemiological studies is inconclusive regarding vitamin D levels and AR risk. Cross‐sectional studies have observed that AR patients had lower vitamin D level, 15 that vitamin D deficiency was associated with higher probability of AR 7 and that the severity of nasal symptoms was negatively associated with serum vitamin D levels in AR patients 47 . Findings from cohort studies were controversial.…”

Section: Discussionmentioning

confidence: 99%

“…6 Previous studies have examined a vitamin D-based strategy for AR and AS prevention, assuming the presence of causality between vitamin D deficiency with allergic disorders. [6][7][8][9][10][11] If a true causality exists, given the high prevalence of vitamin D deficiency world-wide, 12 vitamin D supplementation would be a promising strategy for AR and AS prevention. However, this causality has not been fully confirmed.…”

Section: Introductionmentioning

confidence: 99%

“…The underlying mechanisms are thought to involve paracrine feedback loops that reduce inflammation, differentiation of activated CD4+ T cells and enhancement of suppressor regulatory T‐cell count and functions 6 . Previous studies have examined a vitamin D‐based strategy for AR and AS prevention, assuming the presence of causality between vitamin D deficiency with allergic disorders 6‐11 . If a true causality exists, given the high prevalence of vitamin D deficiency world‐wide, 12 vitamin D supplementation would be a promising strategy for AR and AS prevention.…”

Section: Introductionmentioning

confidence: 99%

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Null association between serum 25‐hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non‐allergic rhinitis: A Mendelian randomization study

Feng

Bønnelykke

et al. 2020

Clin Experimental Allergy

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Background: Previous observational studies have not found a conclusive association between serum 25-hydroxyvitamin D (25(OH)D) levels and allergic rhinitis (AR) or allergic sensitization (AS). Objective: To investigate a causal association between 25(OH)D levels with risk of AR and AS, using a two-sample Mendelian randomization (MR) approach. Methods: Seven single nucleotide polymorphisms (SNPs), previously shown to be associated with serum 25(OH)D levels, were identified as instrumental variables. The primary outcome was AR, and the secondary outcomes were AS and non-allergic rhinitis (NAR). The genome-wide association (GWA) summary statistics of the outcomes were obtained from two cohort studies (EAGLE Consortium and UK Biobank). An MR analysis with random-effects inverse-variance weighted method was performed as the primary analysis to estimate overall effect size (odds ratio [OR] and 95% confidence interval [CI]). Sensitivity analysis using weighted median method and MR-Egger regression method was conducted. A subgroup analysis based on 25(OH)D synthesis-related SNPs was further applied. Results: Serum 25(OH)D levels were not causally associated with risk of AR (OR: 0.960; 95% CI: 0.779-1.184), AS (OR: 1.059; 95% CI: 0.686 to 1.634) or NAR (OR: 0.937; 95% CI: 0.588-1.491). Subgroup analysis also showed null association between 25(OH)D synthesis-related SNPs and the outcomes. Sensitivity analyses yielded similar results. Conclusions and Clinical Relevance: This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European-ancestry population. This argues against the previous postulation that vitamin D supplementation is effective in prevention of allergic diseases.

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Vitamin D Levels as a Potential Modifier of Eosinophilic Esophagitis Severity in Adults

Cameron,

Anderson,

Jensen

et al. 2024

Dig Dis Sci

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Vitamin D: A Modulator of Allergic Rhinitis

Cited by 16 publications

References 29 publications

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Null association between serum 25‐hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non‐allergic rhinitis: A Mendelian randomization study

Vitamin D Levels as a Potential Modifier of Eosinophilic Esophagitis Severity in Adults

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