volume 8, issue 3, P458-483 2016
DOI: 10.18632/aging.100902
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Lucie Aumailley, Alessandra Warren, Chantal Garand, Marie Julie Dubois, Eric R. Paquet, David G. Le Couteur, André Marette, Victoria C. Cogger, Michel Lebel

Abstract: Suboptimal intake of dietary vitamin C (ascorbate) increases the risk of several chronic diseases but the exact metabolic pathways affected are still unknown. In this study, we examined the metabolic profile of mice lacking the enzyme gulonolactone oxidase (Gulo) required for the biosynthesis of ascorbate. Gulo−/− mice were supplemented with 0%, 0.01%, and 0.4% ascorbate (w/v) in drinking water and serum was collected for metabolite measurements by targeted mass spectrometry. We also quantified 42 serum cytoki…

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