2012
DOI: 10.5114/pdia.2012.32394
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Vitamin C: is it time to re-evaluate its role in health and disease?

Abstract: A b s t r a c tVitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Synthetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems t… Show more

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Cited by 4 publications
(1 citation statement)
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“…It facilitates the absorption of non-haem iron and participates in erythropoiesis [ 35 ]. In addition, the immune-stimulating properties of vitamin C and its bacteriostatic properties are stressed [ 43 , 45 – 48 ]. In addition, vitamin C affects the skin immune system – SIS, which performs an important function in the defense of the body.…”
Section: Vitamin Cmentioning
confidence: 99%
“…It facilitates the absorption of non-haem iron and participates in erythropoiesis [ 35 ]. In addition, the immune-stimulating properties of vitamin C and its bacteriostatic properties are stressed [ 43 , 45 – 48 ]. In addition, vitamin C affects the skin immune system – SIS, which performs an important function in the defense of the body.…”
Section: Vitamin Cmentioning
confidence: 99%