1933
DOI: 10.1042/bj0272006
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Abstract: IT is already known that the suprarenal gland is an extremely potent source of vitamin C, but hitherto the activity has been thought to be restricted to the cortex. In the present paper, however, it is shown that the medulla of the suprarenal is also intensely active, its potency falling but little short of that of the cortex. Our results indicate that ox suprarenal cortex has an activity of about 30 international units per gram and ox medulla of about 20 units, i.e. no less than two-thirds of the former. In o… Show more

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Cited by 49 publications
(11 citation statements)
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“…It remains an open question as to whether reduction of the iron(III) in the endosome occurs prior to dissociation from Tf in the Fe 2 -Tf/TfR assembly, or subsequent to dissociation from Tf. A redox-mediated release of iron from transferrin is an attractive hypothesis because the binding constant of transferrin with Fe(II) is 17 orders of magnitude lower than that with Fe (III), and Fe(II) exchanges its first coordination shell at a much faster rate than Fe(III) [5,6]. When bound to the receptor, Fe 2 -Tf has a reduction potential of −300 mV vs. the normal hydrogen electrode (NHE) at pH 5.5, suggesting that a redox-mediated iron-release mechanism is a plausible hypothesis [7][8][9].…”
mentioning
confidence: 99%
“…It remains an open question as to whether reduction of the iron(III) in the endosome occurs prior to dissociation from Tf in the Fe 2 -Tf/TfR assembly, or subsequent to dissociation from Tf. A redox-mediated release of iron from transferrin is an attractive hypothesis because the binding constant of transferrin with Fe(II) is 17 orders of magnitude lower than that with Fe (III), and Fe(II) exchanges its first coordination shell at a much faster rate than Fe(III) [5,6]. When bound to the receptor, Fe 2 -Tf has a reduction potential of −300 mV vs. the normal hydrogen electrode (NHE) at pH 5.5, suggesting that a redox-mediated iron-release mechanism is a plausible hypothesis [7][8][9].…”
mentioning
confidence: 99%
“…The curative method of Harris and Ray (1933) and the weight-response method of Coward (1938) both require six weeks for completion. Coward (1938) found the weight-response method to be as accurate as the tooth method of Key and Elphick (1931).…”
Section: Biological Assay Methods For Vitamin Cmentioning
confidence: 99%
“…Of the biological-assay methods for vitamin C, the standard method of Sherman, LaMer, and Campbell (1922) requires 90 days, although numerous workers have reduced the time to 60 days. The curative method of Harris and Ray (1933) and the weight-response method of Coward (1938) both require six weeks for completion. Coward (1938) found the weight-response method to be as accurate as the tooth method of Key and Elphick (1931).…”
Section: Biological Assay Methods For Vitamin Cmentioning
confidence: 99%
“…III). As the bovine cortex contains about 1-8 mg. ascorbic acid per g. [Harris & Ray, 1933;Glick & Biskind, 1935] the bulk of this must have been destroyed in the extraction process. This suggests that apart from other reducing 01: 0- substances partial oxidation products of ascorbic acid not detectable by indophenol titration might reduce the Folin reagent.…”
Section: Ascorbic Acid Errormentioning
confidence: 99%