1975
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Abstract: A B S T R A C T Individuals with chronic alcohol abuse frequently exhibit lowered plasma levels of pyridoxal 5'-phosphate, the coenzyme form of vitamin Be. Because the liver is the primary source of this coenzyme in plasma and also the principal organ that oxidizes ethanol, the effect of ethanol on hepatic pyridoxal phosphate metabolism was studied in the rat. The chronic feeding of ethanol (36% of the total dietary calories) for 6 wk significantly decreased the hepatic pyridoxal phosphate content both in anim… Show more

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Cited by 68 publications
(18 citation statements)
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References 25 publications
(14 reference statements)
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“…We have previously reported that ethanol oxidation decreases the hepatic content of PLP in isolated perfused rat livers (5). In the present study with isolated hepatocytes, ethanol oxidation has no demonstrable effect on cellular PLP content unless acetaldehyde oxidation was inhibited concomitantly (Fig.…”
Section: Discussionsupporting
confidence: 42%
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“…We have previously reported that ethanol oxidation decreases the hepatic content of PLP in isolated perfused rat livers (5). In the present study with isolated hepatocytes, ethanol oxidation has no demonstrable effect on cellular PLP content unless acetaldehyde oxidation was inhibited concomitantly (Fig.…”
Section: Discussionsupporting
confidence: 42%
“…Whereas pyridoxic acid is biologically inactive, PLP and pyridoxal are the transport forms in plasma. Ethanol oxidation lowers hepatic PLP and impairs the release of this coenzyme (5). As shown here, acetaldehyde also decreases hepatic PLP; however, its effect on the release of PLP and pyridoxal has not been defined.…”
Section: Discussionmentioning
confidence: 63%
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“…increase of esophageal [29], laryngeal [26] and oral cancer [28], high mortality in cardiovascular disease [12], nutrient deficiency [11,23,27], and brain dysfunction [13]. Among women of reproductive age, epidemiological studies have shown that ethanol consumption during pregnancy causes in creased spontaneous abortion and intrauterine growth retardation [20,25], Several reports have described an association between maternal alcoholism and a recogniz able pattern of fetal anomalies termed fetal alcohol syn drome [1,4], Thus, alcohol is suspected of possessing cancerogenic, mutagenic and teratogenic potentials.…”
Section: Introductionmentioning
confidence: 99%