1974
|
Sign up to set email alerts
|

Abstract: A B S T R A CT The plasma pyridoxal-5'-phosphate (PLP) level of alcoholic subjects has been compared with that of non-alcoholic individuals in order to ascertain the incidence of abnormal vitamin Be metabolism in chronic alcohol abuse. 66 alcoholic subjects were selected on the basis that they did not exhibit abnormal liver function tests and hematologic findings. 35 of them had plasma PLP concentrations less than 5 ng/ml, the lowest value encountered in 94 control subjects, indicating a high incidence of dera… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
22
0

Year Published

1976
1976
2006
2006

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 225 publications
(22 citation statements)
references
References 38 publications
(44 reference statements)
0
22
0
Order By: Relevance
“…Some investigations have suggested that aberrations in pyridoxal phosphate formation or destruction result in reduced pyridoxal phsophate levels [ 1, 3, 5 , 61, with consequent reduction of activity of ALA synthetase, resulting in reduced hemoglobin formation and in anemia. However, other studies have failed to demonstrate reduced red-cell pyridoxine-kinase activity [6,7] or any definite relationship between reduced serum pyridoxal phosphate levels and the appearance of ring sideroblasts in alcoholics [8] . The data presented here support the concept that the regulation of pyridoxal phosphate metabolism may not be of importance as it affects bone marrow ALA-synthetase activity.…”
Section: Discussionmentioning
confidence: 99%
“…Some investigations have suggested that aberrations in pyridoxal phosphate formation or destruction result in reduced pyridoxal phsophate levels [ 1, 3, 5 , 61, with consequent reduction of activity of ALA synthetase, resulting in reduced hemoglobin formation and in anemia. However, other studies have failed to demonstrate reduced red-cell pyridoxine-kinase activity [6,7] or any definite relationship between reduced serum pyridoxal phosphate levels and the appearance of ring sideroblasts in alcoholics [8] . The data presented here support the concept that the regulation of pyridoxal phosphate metabolism may not be of importance as it affects bone marrow ALA-synthetase activity.…”
Section: Discussionmentioning
confidence: 99%
“…Several mechanisms have been suggested by which ethanol could interact with one-carbon metabolism and DNA methylation and thereby enhance carcinogenesis (Lu and Mato, 2005). (1) Chronic alcohol interacts with intake, absorption and subsequent metabolism of B vitamins involved in hepatic transmethylation reactions, namely folate and pyridoxal-59-phosphate (vitamin B 6 ), resulting in impaired methyl group synthesis and transfer (Lumeng and Li, 1974;Labadarios et al, 1977;Savage and Lindenbaum, 1986;Gloria et al, 1997;Stickel et al, 2000). (2) Ethanol reduces the activity of methionine synthetase, which remethylates homocysteine to methionine with methyltetrahydrofolate as the methyl donor (Barak et al, 1993;Lieber, 1994).…”
Section: Disturbed Methyl Group Transfermentioning
confidence: 99%
“…In vitro synthesis of PLP by erythrocytes with pyridoxine and pyridoxaminephosphate as substrates, was measured according to the method of Lumeng and Li (11). PLP formed was estimated enzymatically by the tyrosine apodecarboxylase method (6).…”
Section: Methodsmentioning
confidence: 99%
“…PLP phosphatase activity was assayed by mea suring the disappearance of PLP at pH 7.4 by a modification of the method of Lumeng and Li (11). The incubation mixture contained 0.2 ml erythrocytes, 40 nmol triethanolamine buffer pH 7.4, 4 nmol MgClj, 3.8 nmol KC1, 2 nmol PLP in a total volume of 4 ml.…”
Section: Methodsmentioning
confidence: 99%