Vitamin B12 therapy in megaloblastic anemia of infancy

McPherson, A.Z.; Jonsson, Ulfar; Rundles, R. Wayne

doi:10.1016/s0022-3476(49)80277-0

Cited by 19 publications

(3 citation statements)

References 10 publications

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“…The response to vitamin B12 in megaloblastic anaemia of infancy has been more variable; all the children treated with it in the present series responded well, although the dosage in some cases was very high and, according to Frazer (1958), all megaloblastic anaemias will respond to vitamin B12 provided the dosage is high enough. Other workers have reported satisfactory responses (McPherson, Jonsson and Rundles, 1949;Sturgeon and Carpenter, 1950;Zuelzer and Rutzky, 1953) although in some cases the response has been poor (Luhby and Wheeler, 1949;Zuelzer and Rutzky, 1953).…”

Section: Antibiotics a High Proportion Of The Infantsmentioning

confidence: 98%

Megaloblastic Anaemia of Infancy in Jamaica

MacIver¹,

Back²

1960

Archives of Disease in Childhood

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Section: Antibiotics a High Proportion Of The Infantsmentioning

confidence: 98%

Megaloblastic Anaemia of Infancy in Jamaica

MacIver¹,

Back²

1960

Archives of Disease in Childhood

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“…Although folic acid is the drug of choice in the treatment of megaloblastic anaemia of infancy, McPherson et al (1949) and Sturgeon and Carpenter (1950) have reported good results following the administration of vitamin B12. Several cases, however, have shown little or no response to vitamin B12.…”

Section: Aetiologymentioning

confidence: 99%

Megaloblastic Anaemia of Infancy

Rickards¹

1952

BMJ

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JUNE 7, 1952 SULPHONE AND STREPTOMYCIN IN TUBERCULOSIS M}2and P.A.S. gave very good results in a large number of cases of endobronchial tuberculosis. The six cases of this condition treated with streptomycin and sulphone, however, produced only one satisfactory result; two showed considerable improvement and two slight improvement; and one patient, whose strain showed reduced sensitivity before treatment, was unimproved.Complications.-The only serious complication encountered was haemolytic anaemia, which was present in three of the six patients who received a daily dose of 200 mg. or more of D.D.S. One of these showed a drop of over two million red cells per c.mm. in a fortnight. After a short interval (two weeks) treatment was resumed on the reduced dosage scheme, and the haemoglobin slowly improved. In spite of iron administration throughout there was an average drop of 10% haemoglobin in the 22 patients. Methaemalbumin was present in the blood in three of the high-dosage cases, and the violet coloration of the skin associated with this substance was observed in two further cases. Discussion The African leper and the European tuberculous patient appear to differ greatly in their tolerance to sulphone. Lowe's cases (Lowe, 1950) received up to 300 mg. of D.D.S. a day, giving blood levels from 0.8 to 1.4 mg. per 100 ml. without showing haemolysis, whereas a smaller dosage scheme in our cases caused severe haemolysis with a much lower blood sulphone level of from 0.2 to 0.6 mg. per 100 ml. It certainly seemed inadvisable to proceed with our original dosage scheme, which 'was based on the leprosy work, when serious drops in erythrocyte counts occurred with great rapidity.There is no apparent trend suggesting a correlation between blood sulphone levels and emergence of resistant strains. The only surviving sensitive strain was in a patient whose blood sulphone never exceeded 0.15 mg. per 100 ml.The emergence of eight resistant strains and only one fully sensitive strain after eight weeks' streptomycin treatment compares very unfavourably with the findings in the streptomycin and P.A.S. group of the M.R.C. (1950) trial, in which 97% showed a resistance ratio of less than 9 at the same stage of treatment. Bernard et al. (1950) found 51% resistant strains after 70 days of combined streptomycin and sulphone treatment, compared with 91% in the control group treated with streptomycin alone. This result also is much worse than the M.R. Zuelzer and Ogden (1946). The disease occurs predominantly within the first year of life, is characterized by a fairly distinctive clinical pattern, and responds to folic-acid therapy. The response to folic acid is often complete and permanent. Since its original description the disease has often been reported from America, though the only case recorded by British authors is that by Hutchison and MacArthur (1949). A further case is here described and the literature on the subject is briefly reviewed.Case History A baby girl aged 8 months was referred by her practitioner for a blood coun...

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“…Meanwhile the fact was noticed that these children often suffered from infections of the upper respiratory tract and sometimes had diarrhoea, and liver therapy caused a tlocyte crisis and recovery without relapse. Later folic acid (Zuelzer and Ogden, 1946) and vitamin Bn (McPherson, Jonsson and Rundles, 1949) were found to exert the same influe. 1he pathogenesis of these anaemias is still uncertain.…”

mentioning

confidence: 92%

Megalocytic Deficiency Anaemia Cured by Small Amounts of Fresh Endive

Veeneklaas¹

1952

Archives of Disease in Childhood

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Vitamin B12 therapy in megaloblastic anemia of infancy

Cited by 19 publications

References 10 publications

Megaloblastic Anaemia of Infancy in Jamaica

Megaloblastic Anaemia of Infancy in Jamaica

Megaloblastic Anaemia of Infancy

Megalocytic Deficiency Anaemia Cured by Small Amounts of Fresh Endive

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