Vitamin A and keratinization

Logan, W. S.

doi:10.1001/archderm.105.5.748

Cited by 17 publications

(1 citation statement)

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“…Fingernails are more frequently involved than toenails. In the so-called ‘extended’ Laugier-Hunziker syndrome, more widespread areas of pigmentation are seen, for example the fingers and anal mucosa [3]. The most important clinical differential diagnoses are melanoma of the oral mucosa and Peutz-Jeghers syndrome [4].…”

Section: Discussionmentioning

confidence: 99%

Laugier-Hunziker Syndromein a Patient with Pancreatic Cancer

Wondratsch

Feldmann²,

Steiner³

et al. 2012

Case Rep Dermatol

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Section: Discussionmentioning

confidence: 99%

Laugier-Hunziker Syndromein a Patient with Pancreatic Cancer

Wondratsch

Feldmann²,

Steiner³

et al. 2012

Case Rep Dermatol

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Phorbol ester inhibits 13‐cis‐retinoic acid‐induced hydrolysis of phosphatidylinositol 4,5‐bisphosphate in cultured murine keratinocytes: A possible negative feedback via protein kinase C‐activation

Tang

Ziboh

1991

Cell Biochemistry & Function

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The incubation of double-labelled [( 14C]-glycerol and [3H]-myoinositol) keratinocytes with 13-cis retinoic acid induced the transient and simultaneous release of [3H]-inositol trisphosphate ([3H]-InsP3) and [14C]-diacylglycerol ([14C]-DAG) indicating that a possible mode of action of this retinoid on murine keratinocytes may be at least in part the early transient release of the two putative messengers (InsP3 and DAG) from phosphatidylinositol-4,5 bisphosphate (PtdIns4, 5P2). In contrast, the preincubation of the keratinocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) prior to incubation with 13-cis-RA suppressed the 13-cis-RA-induced release of [3H]-InsP3 and [14C]-DAG. The specificity of the TPA effect was established by the lack of effect of the biologically inactive 4 alpha-phorbol 12, 13-didecanoate. Furthermore, the incubation of the TPA-primed keratinocytes with 13-cis-RA caused a delayed and sustained accumulation of [14C]-DAG. An exploration of the source of this late release of [14C]-DAG revealed that this [14C]-DAG was released from non-inositol containing phospholipids, particularly, phosphatidylcholine. This latter DAG released in the TPA-primed cells correlated with the translocation of the cytoplasmic protein kinase C (PKC) activity to the membrane associated PKC activity. Taken together, these results suggest that alteration of PKC activity, presumably induced by DAG released from non-inositol phospholipids, may play a major role in the TPA-induced negative feedback inhibition of 13-cis RA-induced hydrolysis of keratinocyte PtdIns4, 5P2.

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Modulation of growth, differentiation and glycoprotein synthesis by β‐ALL‐trans retinoic acid in a multicellular tumor spheroid model for squamous carcinoma of the head and neck

Sacks

Oke

Amos

et al. 1989

Intl Journal of Cancer

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Cell line MDA 886Ln was established from a laryngeal lymph node metastasis. When grown as a multicellular tumor spheroid (MTS), it exhibits squamous differentiation. We studied the effects of beta-all-trans retinoic acid (RA) on the growth, differentiation and glycoprotein content of this MTS model for squamous carcinomas of the head and neck. The growth of MTSs was inhibited in a dose-dependent manner by 10(-6) to 10(-10) M RA. Growth inhibition occurred between 3 and 5 days of RA treatment (10(-6)M). Immunohistochemical and electrophoretic analyses revealed that RA suppressed the morphological markers of squamous differentiation (squames), involucrin expression, and keratin expression. Gly-coprotein expression was examined by metabolic labelling using 3H-glucosamine, in situ labelling of polyacrylamide gels with 125I-labelled wheat-germ agglutinin (WGA), localization of fluorescein isothionate-WGA in frozen sections, and determination of sialyltransferase activity. Treatment using 10(-6) M RA altered glycoprotein expression both biochemically and morphologically, and WGA was shown to bind preferentially to sialic acid residues. The sensitivity of this MTS model to RA treatment and its ability to be analyzed through morphological, immunohistochemical and biochemical techniques suggest that it will prove useful in studying the relationships between growth, differentiation and RA-induced alterations in squamous carcinomas.

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Vitamin A and keratinization

Cited by 17 publications

References 0 publications

Laugier-Hunziker Syndromein a Patient with Pancreatic Cancer

Laugier-Hunziker Syndromein a Patient with Pancreatic Cancer

Phorbol ester inhibits 13‐cis‐retinoic acid‐induced hydrolysis of phosphatidylinositol 4,5‐bisphosphate in cultured murine keratinocytes: A possible negative feedback via protein kinase C‐activation

Modulation of growth, differentiation and glycoprotein synthesis by β‐ALL‐trans retinoic acid in a multicellular tumor spheroid model for squamous carcinoma of the head and neck

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