Visual Results and Ocular Complications Following Radiotherapy for Retinoblastoma

Use of Irradiation for Therapy of Retinoblastoma in Children More Than 1 Year Old: The St. Jude Children's Research Hospital Experience and Review of Literature

“…'Visual acuity. gReese-Ellswotth ports vary in the often wide ranges of total doses and treatment techniques utilized [3,7,10,11]. It is also infrequent that children less than 1 year of age at diagnosis are evaluated separately from older children despite welldocumented differences in the issues such as the incidence of familial bilateral RB, which has known increased risk of second malignancies, functional and cosmetic results following irradiation.…”

Use of Irradiation for Therapy of Retinoblastoma in Children More Than 1 Year Old: The St. Jude Children's Research Hospital Experience and Review of Literature

“…'Visual acuity. gReese-Ellswotth ports vary in the often wide ranges of total doses and treatment techniques utilized [3,7,10,11]. It is also infrequent that children less than 1 year of age at diagnosis are evaluated separately from older children despite welldocumented differences in the issues such as the incidence of familial bilateral RB, which has known increased risk of second malignancies, functional and cosmetic results following irradiation.…”

Uveal metastatic disease: Current and new treatment options (Review)

“…As other forms of radiation, it induces damage of the DNA of the rapidly growing tumor cells. Radiation has also been used for the treatment of other intraocular malignancies such as uveal melanomas, retinoblastomas and lymphomas (31,33,34). Radiation dose varies greatly but it is usually lower than the dose required for uveal melanomas thus decreasing the complications of radiation such as radiation retinopathy (4,20,35).…”

Chemoreduction Followed by Local Therapy and Adjuvant Chemotherapy for Advanced Intraocular Retinoblastoma: A Pilot Study in a Single Center

“…EBRT can be used as a primary treatment modality or adjuvant therapy after ENU (5,6). But it can cause many serious late complications including cosmetic deformity and second malignancy (6)(7)(8). For these reasons, there has been a substantial decrease in the frequency of ENU or EBRT over the recent decades, a great portion of which is attributable to the advance in CRx and local treatment modalities (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Use of Irradiation for Therapy of Retinoblastoma in Children More Than 1 Year Old: The St. Jude Children's Research Hospital Experience and Review of Literature

“…'Visual acuity. gReese-Ellswotth ports vary in the often wide ranges of total doses and treatment techniques utilized [3,7,10,11]. It is also infrequent that children less than 1 year of age at diagnosis are evaluated separately from older children despite welldocumented differences in the issues such as the incidence of familial bilateral RB, which has known increased risk of second malignancies, functional and cosmetic results following irradiation.…”

Uveal metastatic disease: Current and new treatment options (Review)

“…As other forms of radiation, it induces damage of the DNA of the rapidly growing tumor cells. Radiation has also been used for the treatment of other intraocular malignancies such as uveal melanomas, retinoblastomas and lymphomas (31,33,34). Radiation dose varies greatly but it is usually lower than the dose required for uveal melanomas thus decreasing the complications of radiation such as radiation retinopathy (4,20,35).…”

Chemoreduction Followed by Local Therapy and Adjuvant Chemotherapy for Advanced Intraocular Retinoblastoma: A Pilot Study in a Single Center

“…EBRT can be used as a primary treatment modality or adjuvant therapy after ENU (5,6). But it can cause many serious late complications including cosmetic deformity and second malignancy (6)(7)(8). For these reasons, there has been a substantial decrease in the frequency of ENU or EBRT over the recent decades, a great portion of which is attributable to the advance in CRx and local treatment modalities (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Use of Irradiation for Therapy of Retinoblastoma in Children More Than 1 Year Old: The St. Jude Children's Research Hospital Experience and Review of Literature

“…'Visual acuity. gReese-Ellswotth ports vary in the often wide ranges of total doses and treatment techniques utilized [3,7,10,11]. It is also infrequent that children less than 1 year of age at diagnosis are evaluated separately from older children despite welldocumented differences in the issues such as the incidence of familial bilateral RB, which has known increased risk of second malignancies, functional and cosmetic results following irradiation.…”

Uveal metastatic disease: Current and new treatment options (Review)

“…As other forms of radiation, it induces damage of the DNA of the rapidly growing tumor cells. Radiation has also been used for the treatment of other intraocular malignancies such as uveal melanomas, retinoblastomas and lymphomas (31,33,34). Radiation dose varies greatly but it is usually lower than the dose required for uveal melanomas thus decreasing the complications of radiation such as radiation retinopathy (4,20,35).…”

Chemoreduction Followed by Local Therapy and Adjuvant Chemotherapy for Advanced Intraocular Retinoblastoma: A Pilot Study in a Single Center

“…EBRT can be used as a primary treatment modality or adjuvant therapy after ENU (5,6). But it can cause many serious late complications including cosmetic deformity and second malignancy (6)(7)(8). For these reasons, there has been a substantial decrease in the frequency of ENU or EBRT over the recent decades, a great portion of which is attributable to the advance in CRx and local treatment modalities (9)(10)(11)(12)(13)(14)(15)(16)(17).…”