Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas: Our Institutional Experience

Essen, Max J. van; Muskens, Ivo S.; Lamba, Nayan; Belunek, Stephan F.J.; Boog, Arthur T.J. van der; Amelink, G. J.; Gosselaar, Peter H.; Doormaal, Tristan P.C. van; Stades, Aline M.E.; Verhoeff, Joost J.C.; Genderen, Maria M. van; Eenhorst, Christine A.E.; Broekman, Marike L D

doi:10.1055/s-0039-3402020

Cited by 2 publications

(1 citation statement)

References 38 publications

(58 reference statements)

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“…In addition, previous studies have focused on the factors influencing postoperative visual field recovery, including the duration of symptoms, the preoperative mean defect (MD), age, retinal nerve fiber layer (RNFL) thickness, tumor volume, suprasellar tumor extension, and expression levels of vascular endothelial growth factor (VEGF)/Ki-67 ( 12 – 15 ).…”

Section: Introductionmentioning

confidence: 99%

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

Zhuang²,

Yang³

et al. 2023

Front. Oncol.

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PurposeTo analyze and predict the possibility of visual field (VF) recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma, we investigated the factors affecting the improvement of the visual field defect (VFD) and built a nomogram predictive model based on these risk factors. We further investigated specific recovery regions of VF associated with the improvement of VFD.MethodsThe clinical data of patients who underwent ETSS for pituitary adenomas at a single center between the January 2021 and April 2022 were retrospectively analyzed. Univariate and multivariate analyses were used to determine the predictive factors affecting the improvement in the VF defect and specific recovery regions in patients with pituitary adenomas after ETSS.ResultsWe enrolled 28 patients (56 eyes) who were hospitalized at our institution. Four clinical features, including compression of the optic chiasm, preoperative mean defect (MD), diffuse defect, and duration of the visual symptom, were chosen from the least absolute shrinkage and selection operator regression analysis to establish the predictive nomogram. The nomogram’s area under the curve (AUC) was 0.912, indicating a good degree of differentiation. A calibration plot was used to evaluate the predictive model’s calibration, and a decision curve was used to evaluate its clinical application value. The VF defects were improved in the 270–300° range (270–300: RR = 361.00, 95% CI: 21.01–6,202.41).ConclusionWe developed a predictive nomogram model based on significant visual field improvement-associated factors after ETSS in patients with pituitary adenoma. Postoperative visual field improvement is likely to begin at 270–300° in the inferior temporal quadrant. This improvement would enable personalized counselling for individual patients by precisely predicting the visual field recovery after surgery.

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Section: Introductionmentioning

confidence: 99%

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

Zhuang²,

Yang³

et al. 2023

Front. Oncol.

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Multidisciplinary Team Care in Pituitary Tumours

Marques,

Sagarribay,

Tortosa

et al. 2024

Cancers

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The optimal care for patients with pituitary tumours is best provided in a multidisciplinary and collaborative environment, which requires the contribution of multiple medical specialties working together. The benefits and advantages of the pituitary multidisciplinary team (MDT) are broad, and all relevant international consensus and guidelines in the field recommend that patients with pituitary tumours should always be managed in a MDT. Endocrinologists and neurosurgeons are normally the leading specialties within the pituitary MDT, supported by many other specialties with significant contributions to the diagnosis and management of pituitary tumours, including neuropathology, neuroradiology, neuro-ophthalmology, and otorhinolaryngology, among others. Here, we review the literature concerning the concepts of Pituitary MDT/Pituitary Tumour Centre of Excellence (PTCOE) in terms of their mission, goals, benefits, structure, proposed models of function, and barriers, and we also provide the views of different specialists involved in our Pituitary MDT.

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Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas: Our Institutional Experience

Cited by 2 publications

References 38 publications

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

Multidisciplinary Team Care in Pituitary Tumours

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