Visual outcome after corneal transplantation for corneal perforation and iris prolapse in 37 horses: 1998–2010

Henriksen, Michala de Linde; Plummer, Caryn E.; Mangan, Brendan G.; Ben‐Shlomo, Gil; Tsujita, Hiroki; Greenberg, Shari M.; Toft, Nils; Brooks, Dennis

doi:10.1111/j.2042-3306.2012.00657.x

Cited by 15 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Perforation with iris prolapse is a high risk factor for infectious endopthalmitis (de Linde Henriksen et al . ). Other complications can include uveitis, phthsis bulbi, anterior and posterior synechiae, cataract formation and glaucoma (Denis ).…”

Section: Discussionmentioning

confidence: 97%

“…Corneal allografting has been described to treat corneal perforations and iris prolapse in horses with some success (de Linde Henriksen et al . ). Various biomaterials have also been used to repair corneal injuries including amniotic membrane (Lassaline et al .…”

Section: Introductionmentioning

confidence: 97%

“…Conjunctiva is frequently used as pedicles or isolated island grafts to cover the defect. Corneal allografting has been described to treat corneal perforations and iris prolapse in horses with some success (de Linde Henriksen et al 2012). Various biomaterials have also been used to repair corneal injuries including amniotic membrane (Lassaline et al 2005;Plummer 2009), submucosa of porcine small intestine (Goulle 2012) and extracellular matrix of porcine bladder (ACell Vet corneal discs) 1 (Balland et al 2016;Mancuso et al 2016).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

Davis

Riggs

Chow³

2017

Equine Veterinary Education

View full text Add to dashboard Cite

Summary This report describes the use of porcine urinary bladder matrix (UBM) to repair a full thickness defect in the cornea of a Thoroughbred racehorse. The horse presented with acute keratomalacia of the right eye of 12 h duration that had rapidly progressed to perforation of the cornea with partial iris prolapse. The cornea was surgically debrided with the horse under general anaesthesia and the defect repaired with ACell multilayer wound matrix. A temporary tarsorrhaphy was performed. The defect in the cornea was successfully repaired and the horse regained vision in the eye. Four months after surgery the defect was still undergoing remodelling and the area of opacity in the cornea was progressively reducing.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

Davis

Riggs

Chow³

2017

Equine Veterinary Education

View full text Add to dashboard Cite

show abstract

“…eine eingeschränkte Sehfähigkeit unter Umständen fatal und kann einen erheblichen wirtschaftlichen Verlust für den Tierhalter bedeuten. Die Therapie von Hornhautulzera stellt eine Herausforderung dar, denn innerhalb kurzer Zeit kann es durch enzymatische Zerstörung des Stromas zu Schäden von großem Ausmaß bis hin zu einer Perforation der Hornhaut kommen (Strubbe et al 2000, Haffner et al 2003, De Linde Henriksen et al, 2012. Eine fundierte Aufklärung der Besitzer hinsichtlich der Behandlungsmöglich-keiten, der Prognose für den Erhalt des Auges und der Sehfä-higkeit sowie der Dauer der Behandlung ist schwierig (Höpp-ner 2007).…”

Section: Introductionunclassified

Equine corneal ulcers – A retrospective evaluation of 78 horses (2008–2011)

Pape¹,

Gerhards²

2015

PHK

View full text Add to dashboard Cite

(p <0,01). Zur Beurteilung des klinischen Schweregrades wurden Kriterien wie der Grad der Hyperämie der Konjunktiva, das Vorhandensein von Gefäßen in der Hornhaut und die Pupillenstellung mit 3 bis 9 Punkten bewertet und zu einem Gesamtscore addiert, welcher einem gering-, mittel-oder hochgradigen klinischen Schweregrad der Hornhautulzera zugeordnet werden konnte. Anhand des klinischen Scoringsystem ist es möglich, nach Aufnahme des Einlieferungsbefundes fundierte prognostische Aussagen bezüglich der Sehfähigkeit, des Reizzustandes des Auges und der Bulbuserhaltung bei der Entlassung zu machen. Der Grund für eine Prädisposition älterer Pferde in der Entstehung von Hornhautulzera wird neben einer altersabhängigen Strukturveränderung der Kornea sowie Veränderungen in der kornealen Physiologie, der Immunabwehr und der Zusammensetzung der konjunktivalen Mikroflora vermutet. Patienten über 12 Jahre wiesen demnach ein höheres Risiko auf an einem Hornhautulkus zu erkranken. Die intensive medikamentöse und aggressive chirurgische Therapie ist auch im frühen Stadium kornealer Ulzerationen anzuwenden, um schwere klinische Verläufe, die häufig mit einer sehr langen stationären Behandlung einhergehen, zu verhindern. The purpose of this retrospective study was to determine prevalence, predispositions, typical therapy and the prognosis for equine corneal ulcers, so as to gain new findings in the clinical course and to form recommendations for therapy methods. Another aim was to develop a well-founded scoring system classifying and evaluating the degree of the severity of corneal ulcers in horses, in order to estimate objectively the severity of corneal ulcerations as well as the prognosis for vision and globe survival. Medical Records of horses diagnosed with corneal ulceration and a treatment as an inpatient at the Equine Clinic from 1st January 2008 to 31st December 2011 were reviewed. The patients' data of all horses seen at the Equine Clinic during the same period (3436 horses) served as reference data. Results: A total of 78 horses, 2.2 % of all clinic patients (3514), suffered from corneal ulceration. Although corneal ulcerations were found in every season, fungal corneal ulcers tent to accumulate in the summer month. The mean age of patients with corneal ulcers was 13.7 years. This was highly significantly older than the average age of patients of the reference group with 9.8 years (p <0,01). Seventeen of seventy-four (17/74; 23 %) patients were treated without surgical intervention and 57/74 (77 %) horses received surgical treatment with either debridement or keratectomy alone or keratectomy with conjunctival flap. The globe-survival-rate was 80.8 % and the eyes were visual in 30.6 % (22/72). The time of hospitalisation was 28.3 days on average. This was highly significantly longer than the mean time of hospitalisation of every other patient at the Equine Clinic (p<0,01). Clinical information was used to build up a scoringsystem using three clinical criteria to calculate clinical severity of the corneal ulceration. A...

show abstract

“…Ulcerative keratitis is an important and eye threatening disease in horses [1][2][3][4][5][6]. Infection and tear film hyperprotease activity manifested as "melting cornea" or keratomalacia are important components of corneal ulceration in horses.…”

Section: Introductionmentioning

confidence: 99%

In Vitro efficacy and antiprotease activity of an antimicrobial ophthalmic drug combination against corneal pathogens of horses

Ben‐Shlomo¹,

Brooks²,

Plummer³

2013

Vet Med Anim Sci

View full text Add to dashboard Cite

Background: Despite limited information, topical drug combinations are being routinely used by equine veterinarians for the treatment of equine keratitis in order to minimize the intensive labor and costs associated with such treatment with individual drugs. Typical drug combination includes antimicrobials, atropine and antiproteases for the treatment of infection, uveitis and keratomalacia respectively. The goal of this study was to evaluate the in vitro efficacy of an ophthalmic drug combination against protease activity and common equine corneal pathogens. Methods: Multiple representative isolates of three bacterial and two fungal corneal pathogens of horses were subjected to minimum inhibitory concentration testing of a drug combination that consisted of equal volumes of natamycin, tobramycin, and cefazolin. Proteinase inhibitory activity of the drug combination was assessed by use of a fluorescence microplate assay with gelatin and collagen I as substrates. The Minimal inhibitory concentrations were compared between the drug combination and each of its components; antiproteinase activity of the drug combination was compared with that of serum by use of paired t-tests and a one-way analysis of variance, respectively. Results: The drug combination did not inhibit the collagenase and protease activity compared to control (P>0.49). The three bacterial pathogens were susceptible to both the drug mix and cefazolin alone. Although one of four isolates of S. aureus was resistant to tobramycin alone, the rest of the isolates showed susceptibility to tobramycin. None of the bacterial isolates was sensitive to natamycin alone. All fungal isolates were susceptible to the drug combination and natamycin alone, with the exception of one Fusarium isolate which was susceptible to the drug combination but not to natamycin alone. None of the fungal isolates was susceptible to cefazolin or tobramycin alone. Conclusions: This drug combination effectively inhibited common corneal pathogens of horses in vitro, but was not effective as an antiprotease treatment. Combining anitimicrobial drugs with serum, does not increase the antimicrobials potency, but reduces the efficacy of the serum as an antiprotease agent.

show abstract

Visual outcome after corneal transplantation for corneal perforation and iris prolapse in 37 horses: 1998–2010

Cited by 15 publications

References 10 publications

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

Equine corneal ulcers – A retrospective evaluation of 78 horses (2008–2011)

In Vitro efficacy and antiprotease activity of an antimicrobial ophthalmic drug combination against corneal pathogens of horses

Contact Info

Product

Resources

About