Visual loss in sarcoid‐related uveitis

Lobo, Aires; Barton, Keith; Minassian, Darwin; Bois, Roland M. du; Lightman, Susan

doi:10.1046/j.1442-9071.2003.00666.x

Cited by 68 publications

(66 citation statements)

References 25 publications

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“…To increase its relevance and favour comparisons with previous studies,5–7 11 histological proof and exclusion of other granulomatous diseases were required for inclusion. This step matches the first level of diagnosis outlined in the International Workshop on Sarcoidosis 12.…”

Section: Discussionmentioning

confidence: 99%

Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis

et al. 2016

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“…[1][2][3][4] Experimental autoimmune uveitis (EAU) is an animal model of human autoimmune uveitis and has been widely used for dissecting mechanisms and developing treatment strategies. 5 EAU is induced by immunization with retinal antigens such as interphotoreceptor retinoid-binding protein (IRBP), 6,7 and activated and sensitized Th1 and Th17 cells are considered to play a major role in initiation and maintenance of the intraocular inflammation.…”

mentioning

confidence: 99%

Aminoimidazole Carboxamide Ribonucleotide Ameliorates Experimental Autoimmune Uveitis

Suzuki

Yoshimura

Simeonova

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…2b). There are a few reports on associations of APMPPE with either probable sarcoidosis [1,2] or CNS abnormalities [3]. Histopathological studies have shown the latter to be caused by granulomatous arteritis of medium-sized arteries [4].…”

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confidence: 99%

Acute posterior multifocal placoid pigment epitheliopathy with concurrent cerebral vasculitis and sarcoidosis

Prokosch

Becker²,

Thanos

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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Dear Editor, Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a distinct clinical entity of unknown origin, characterized by the acute onset of multiple lesions at the posterior retinal pole at the pigment epithelium level. The clinical course is usually self-limited. In this report, a case of APMPPE emerging simultanously with sarcoidosis and CNS vascular abnormalities is described, suggesting that APMPPE is associated with a generalized inflammatory disease.A 40-year-old woman presented with bilateral visual field defects. Ophthalmoscopy showed multiple yellowwhite placoid lesions at the posterior pole of both eyes (Fig. 1a). Fluorescein angiography demonstrated an early hypofluorescence and a late hyperfluorescence of the lesions characteristic of APMPPE (Fig. 1b). The medical history included episodes of fever, cough and painful nodular skin lesions. Biopsy of these skin lesions demonstrated granulomatous epitheloid cells consistent with erythema nodosum. X-ray disclosed bilateral enlargement of the hilar lymph nodes, suggestive of sarcoidosis. Bronchoalveolar lavage showed a high CD4/CD8 ratio of 3.6: transbronchial biopsy revealed non-caseating granulomas (Fig. 2a), and the serum level of angiotension-converting enzyme was elevated. Cranial MRI revealed stenosis of the left middle cerebral artery (Fig. 2b).There are a few reports on associations of APMPPE with either probable sarcoidosis [1,2] or CNS abnormalities [3]. Histopathological studies have shown the latter to be caused by granulomatous arteritis of medium-sized arteries [4]. Fig. 1 Multiple yellow-white placoid lesions at the posterior pole (a), showing late hyperfluorescence in fluorescence angiography (b) V. Prokosch (*) : S. Thanos :

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Visual loss in sarcoid‐related uveitis

Abstract: Multifocal choroiditis is a less common manifestation of uveitis associated with sarcoidosis but appears to be associated with a worse visual prognosis despite immunosuppressive therapy.

Cited by 68 publications

References 25 publications

Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis

Long-term visual and systemic prognoses of 83 cases of biopsy-proven sarcoid uveitis

Aminoimidazole Carboxamide Ribonucleotide Ameliorates Experimental Autoimmune Uveitis

Acute posterior multifocal placoid pigment epitheliopathy with concurrent cerebral vasculitis and sarcoidosis

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