Visual impairment in children with congenital Zika syndrome

Ventura, Liana O.; Ventura, Camila V.; Lawrence, Linda; Linden, Vanessa van der; Linden, Ana van der; Gois, Adriana L.; Cavalcanti, Milena M.; Barros, Eveline; Dias, Natália; Berrocal, Audina M.; Miller, Marilyn T.

doi:10.1016/j.jaapos.2017.04.003

Cited by 74 publications

(153 citation statements)

References 22 publications

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“…Infants with congenital Zika syndrome present with a range of ocular abnormalities, but the two classic retinal appearances are well‐circumscribed atrophy and pigment mottling at the macula . Regardless of ocular involvement, all infants with congenital Zika syndrome have displayed significant visual impairment, suggesting that cortical rather than ocular dysgenesis is the most common cause of blindness . In adults, ocular complications of ZIKV infection tend to be mild and self‐limiting.…”

Section: Zika Virus Diseasementioning

confidence: 99%

“…48 Pregnant women who contract ZIKV risk preterm birth, miscarriage and a congenital Zika syndrome that consists of intrauterine growth retardation, microcephaly, brain, auditory, skeletal and ocular abnormalities. 49 Children with congenital Zika syndrome have widespread functional disabilities and an unknown prognosis. 49 Like DENV, ZIKV is transmitted by the daytime-biting Aedes mosquito species.…”

Section: Overview Of Zika Virus Diseasementioning

confidence: 99%

“…49 Children with congenital Zika syndrome have widespread functional disabilities and an unknown prognosis. 49 Like DENV, ZIKV is transmitted by the daytime-biting Aedes mosquito species. 25 Incubation lasts up to 2 wk, and infection is subclinical in 80% of individuals.…”

Section: Overview Of Zika Virus Diseasementioning

confidence: 99%

“…53 Regardless of ocular involvement, all infants with congenital Zika syndrome have displayed significant visual impairment, suggesting that cortical rather than ocular dysgenesis is the most common cause of blindness. 49 In adults, ocular complications of ZIKV infection tend to be mild and self-limiting. Retro-orbital pain and conjunctivitis are common, affecting 40% in one study.…”

Section: Zikv-associated Uveitismentioning

confidence: 99%

See 3 more Smart Citations

Emerging infectious uveitis: Chikungunya, dengue, Zika and Ebola: A review

Oliver

Carr

Smith

2019

Clinical Exper Ophthalmology

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Recently recognized forms of uveitis include intraocular inflammations that occur during or following one of several emerging infectious diseases: chikungunya fever, dengue, Zika virus disease and Ebola virus disease. Anterior, intermediate, posterior and pan‐uveitis have been described in individuals infected with chikungunya virus. Persons who contract dengue or Zika viruses also may develop different types of uveitis in the course of the infection: maculopathy is a common manifestation of dengue eye disease, and Zika eye disease may cause hypertensive anterior uveitis or mimic a white dot syndrome. Up to one‐third of Ebola survivors develop aggressive uveitis, which is frequently associated with vision loss and complicated by cataract. There are no specific anti‐viral drugs for these forms of uveitis, and thus treatment is largely supportive. In this article, we summarize the systemic infectious diseases and virology, and describe the clinical presentations, outcomes and management of emerging viral forms of uveitis.

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Section: Zika Virus Diseasementioning

confidence: 99%

Section: Overview Of Zika Virus Diseasementioning

confidence: 99%

Section: Overview Of Zika Virus Diseasementioning

confidence: 99%

Section: Zikv-associated Uveitismentioning

confidence: 99%

See 2 more Smart Citations

Emerging infectious uveitis: Chikungunya, dengue, Zika and Ebola: A review

Oliver

Carr

Smith

2019

Clinical Exper Ophthalmology

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“…The most frequently reported were macular atrophy, pigment mottling (63%), optic nerve anomalies (such as hypoplasia with double ring sign) (11%), lacunar maculopathy (6.9%), foveal reflex loss, and increased cupdisk ratio [31,43,54,55]. Additionally, Yepez et al [54] recently reported congenital glaucoma, corneal clouding, buphthalmos, increased intraocular pressure, and the clinical triad of epiphora, blepharospasm, and photophobia in infants with microcephaly.…”

Section: Congenital and Intrauterine Zika Virus Infectionmentioning

confidence: 99%

Global Alert: Zika Virus-an Emerging Arbovirus

Özkurt¹,

Tanrıverdi²

2017

Eurasian J Med

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Zika virus (ZIKV) is an arbovirus of the Flavivirus genus, and it has an envelope and a single RNA molecule. In early 2016, the World Health Organization declared ZIKV infection to be an emerging global health threat. The major transmission route of the virus to humans is Aedes mosquitoes. ZIKV can be transmitted between humans by transplacental, perinatal, and sexual routes and via blood and body fluids. ZIKV infection usually results in a mild and self-limiting disease with low-grade fever, conjunctivitis, and periorbital edema. Neurological complications such as Guillain-Barré syndrome, meningoencephalitis, acute disseminated encephalomyelitis, acute myelitis, and transverse myelitis have been reported during ZIKV infection. Intrauterine and congenital ZIKV infections have strong teratogenic effects on the fetus. Intrauterine or congenital ZIKV infection can lead to microcephaly, ocular anomalies (such as macular atrophy, pigment mottling, and optic nerve anomalies), and cardiac anomalies (such as atrial or ventricular septal defect). Calcification in the brain between the cortical and subcortical areas, ventriculomegaly, cerebellar hypoplasia, corpus callosum hypoplasia, cortical/subcortical atrophy, delayed myelination, enlarged cisterna magna, and craniofacial disproportion have been reported as brain development defects. ZIKV infection usually results in a mild disease, and it does not require specific therapy. However, complications of infection during the early period of life are serious. Thus, many drugs have been investigated, and vaccine development studies have been conducted to prevent ZIKV infection. Vector control and personal protection from mosquito-borne transmission are important for decreasing the prevalence of ZIKV infection. In particular, pregnant residents or travelers to endemic areas should be carefully protected against mosquito-borne transmission.Keywords: Zika virus, Flavivirus, microcephaly, Guillain-Barré Syndrome, aedes, arbovirus ÖZ Zika virus (ZIKV), Flavivirus ailesinden sivrisineklerle bulaşan zarflı ve tek sarmallı RNA'ya sahip bir arbovirusdur. 2016 yılı başında Dünya Sağlık Örgütü (DSÖ) ZIKV enfeksiyonunun giderek önemi artan bir küresel tehdit olduğunu açıklamıştır. Virusun insanlara esas geçiş yolu Aedes tipi sivrisineklerin ısırmasıdır. İnsanlar arasında transplasental, perinatal, cinsel yolla, ayrıca kan ve vücut sıvıları aracılığı ile bulaşır. ZIKV enfeksiyonu genellikle hafif ve kendini sınırlandıran hastalık olup, düşük derecede ateş, konjuktivit ve periorbital ödem ile seyreder. ZIKV enfeksiyonu esnasında Guillain-Barre sendromu, meningoensefalit, akut dissemine ensefalomyelit (ADEM), akut myelit, transvers myelit gibi nörolojik komplikasyonlar rapor edilmiştir. Intrauterin ve konjenital ZIKV enfeksiyonu fetus üzerinde ağır teratojenik etkiye sahiptir. İntrauterin enfeksiyon mikrosefali, oküler anomaliler (maküler atrofi, pigment beneklenmesi ve optik sinir anomalileri gibi) ve kardiyak anomalilere (atrial veya ventriküler septal defekt gibi) yol açabilir. ...

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Pathogenesis of Ocular Findings in Congenital Zika Syndrome

2017

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Since the Zika virus (ZIKV) infection outbreak in Brazil in 2015 and the subsequent reported cases of congenital Zika syndrome (CZS; 2694 cases reported), efforts have been made to answer questions regarding how the virus causes developmental defects, ocular manifestations, and visual impairment. 1,2 The typical findings in CZS are cranial alterations, posterior ocular manifestations, and musculoskeletal deformities. 1,2 Visual impairment is not only caused by ophthalmic manifestations; Ventura et al 3 reported that regardless of fundus involvement, patients with ZIKV syndrome can present with visual impairment. Some studies have reported a lack of microcephaly in babies with CZS. 1,4 The current thought is that visual impairment in babies with CZS is due to ophthalmic manifestations, neurological alterations, or both.Efforts have been made to understand how ZIKV causes cranial malformations and central nervous system abnormalities in newborn babies. The Zika virus exhibits tropism for neuronal progenitors in the developing brain of the fetus, causing direct injury to its progenitor cells by apoptosis, inducing inflammatory cytokine production and promoting neuronal cell death. 1,5 Chavali et al 6 reported that the ZIKV RNA genome binds to RNA-binding protein Musashi homolog 1 (MSI1), which is highly expressed in progenital precursors of neurons and astrocytes. MSI1 binds to the 5′ and 3′ untranslated region and promotes translation of the structural proteins. This MSI1-ZIKV RNA binding complex decreases normal MSI1 interaction with messenger RNAs (mRNAs), thus decreasing expression of microcephalin, cyclin-dependent kinase 6, protein NUMB, and p21, all of which are responsible for human brain development, cell division cycle control, proliferation of neuronal precursors, and cortical development. 5 More efforts need

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Visual impairment in children with congenital Zika syndrome

Cited by 74 publications

References 22 publications

Emerging infectious uveitis: Chikungunya, dengue, Zika and Ebola: A review

Emerging infectious uveitis: Chikungunya, dengue, Zika and Ebola: A review

Global Alert: Zika Virus-an Emerging Arbovirus

Pathogenesis of Ocular Findings in Congenital Zika Syndrome

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