Visible optical radiation generates bactericidal effect applicable for inactivation of health care associated germs demonstrated by inactivation of E. coli and B. subtilis using 405-nm and 460-nm light emitting diodes

Hönes, Katharina; Stangl, Felix; Sift, Michael; Heßling, Martin

doi:10.1117/12.2183903

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…. Data were collected from several studies which investigated the inactivation of bacteria, using different wavelengths of violet‐blue light, held under similar exposure conditions in each study . Figure a demonstrates data for Gram‐positive isolates, with the dose required for a 1 log 10 reduction increasing for all organisms when wavelength is increased from 405–415 nm to 450–470 nm.…”

Section: Resultsmentioning

confidence: 99%

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Review of the Comparative Susceptibility of Microbial Species to Photoinactivation Using 380–480 nm Violet‐Blue Light

Tomb

White

Coia

et al. 2018

Photochem & Photobiology

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Antimicrobial violet-blue light is an emerging technology designed for enhanced clinical decontamination and treatment applications, due to its safety, efficacy and ease of use. This systematized review was designed to compile the current knowledge on the antimicrobial efficacy of 380-480 nm light on a range of health care and food-related pathogens including vegetative bacteria, bacterial endospores, fungi and viruses. Data were compiled from 79 studies, with the majority focussing on wavelengths in the region of 405 nm. Analysis indicated that Gram-positive and Gram-negative vegetative bacteria are the most susceptible organisms, while bacterial endospores, viruses and bacteriophage are the least. Evaluation of the dose required for a 1 log 10 reduction of key bacteria compared to population, irradiance and wavelength indicated that microbial titer and light intensity had little effect on the dose of 405 nm light required; however, linear analysis indicated organisms exposed to longer wavelengths of violet-blue light may require greater doses for inactivation. Additional research is required to ensure this technology can be used effectively, including: investigating inactivation of multidrug-resistant organisms, fungi, viruses and protozoa; further knowledge about the photodynamic inactivation mechanism of action; the potential for microbial resistance; and the establishment of a standardized exposure methodology.

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Section: Resultsmentioning

confidence: 99%

“…The final 79 research articles reviewed contained inactivation data on clinically relevant and food‐associated microorganisms exposed to violet‐blue light between 380 and 480 nm. Data from each article were extracted, summarized and tabulated (see Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Review of the Comparative Susceptibility of Microbial Species to Photoinactivation Using 380–480 nm Violet‐Blue Light

Tomb

White

Coia

et al. 2018

Photochem & Photobiology

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“…The spectra of the applied LEDs and the potentially involved bacterial photosensitizers can be found in Figure 2. The homogeneous irradiation of the bacterial samples was achieved with a pyramid-shaped mirror arrangement as described previously [7,21]. Because of the potential influence of the violet LED on human color perception color coordinates, correlated color temperature and color rendering indices (CRI) of the warm-white LED, the violet LED and the combination of both were calculated.…”

Section: Irradiation Setupmentioning

confidence: 99%

Disinfection Properties of Conventional White LED Illumination and Their Potential Increase by Violet LEDs for Applications in Medical and Domestic Environments

Buehler¹,

Sommerfeld²,

Meurle³

et al. 2021

Adv. Sci. Technol. Res. J.

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The antimicrobial impact of visible violet and blue light has been known for more than a century but hardly been applied for purposeful pathogen reduction or prevention. The disinfecting properties of wide-spread warm-white and cool-white light emitting diodes (LEDs) are investigated by irradiation of staphylococci with different LEDs and varying doses. Additionally, the combination of a white and a violet LED illumination is examined. Both white LEDs exhibit an antimicrobial effect, which seems to be dominated by the blue parts of the LED emissions. Unfortunately, the antimicrobial effect is weak in realistic illumination applications. Additional violet LEDs can significantly enhance this impact without a large change in human color perception. This allows reasonable applications in certain medical and domestic environments without endangering humans.

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Prussian Blue@Zeolitic imidazolate framework composite toward solar-triggered biodecontamination

Wang

Ma²,

Chen³

et al. 2023

Chemical Engineering Journal

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Visible optical radiation generates bactericidal effect applicable for inactivation of health care associated germs demonstrated by inactivation of E. coli and B. subtilis using 405-nm and 460-nm light emitting diodes

Cited by 8 publications

References 6 publications

Review of the Comparative Susceptibility of Microbial Species to Photoinactivation Using 380–480 nm Violet‐Blue Light

Review of the Comparative Susceptibility of Microbial Species to Photoinactivation Using 380–480 nm Violet‐Blue Light

Disinfection Properties of Conventional White LED Illumination and Their Potential Increase by Violet LEDs for Applications in Medical and Domestic Environments

Prussian Blue@Zeolitic imidazolate framework composite toward solar-triggered biodecontamination

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