Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review

Zheng, Zizhuo; Eglin, David; Alini, Mauro; Richards, Geoff; Qin, Ling; Lai, Yuxiao

doi:10.1016/j.eng.2020.05.021

Cited by 118 publications

(109 citation statements)

References 106 publications

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“…3D printing or additive manufacturing (AM) consists of producing a three-dimensional object of almost any shape or geometry by forming successive layers of material under computer control using digital model data [ 9 , [80] , [81] , [82] ]. 3D bioprinting is the utilization of 3D printing technology and bioinks (bioprintable materials) to fabricate complex 3D functional living tissues by combining living cells, biomaterials, and biochemicals, using several different methods with different characteristics summarized in Table 1 [ [83] , [84] , [85] , [86] , [87] ]. Bioprinted scaffolds can be fabricated using several different methods, each of which possesses its own advantages, disadvantages, and material demands.…”

Section: Biofabrication Of Natural Hydrogel-based Scaffoldsmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

109

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Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.

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Section: Biofabrication Of Natural Hydrogel-based Scaffoldsmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

109

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“…Due to the ability of 3D printing to create porous scaffolds with complex structure and the good perspective in the 3D fabrication of personalized grafts, [ 108 ] in the past few years, a large number of articles have explored this manufacturing process to produce tissue engineering grafts. [ 109,110 ] Combined with 3D printing, the use of nanostructured materials has also been employed due to its versatile functionalities: These materials improve drug solubility and stability and act as drug carriers. In addition, they can increase the surface area of materials or help in the process of cell adhesion, specifically in cell growth.…”

Section: D Printing and Nanotechnology Alliancementioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

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3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus‐response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.

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“…Different technologies use this approach, like stereolithography (SLA), digital light processing (DLP), continuous digital light processing (CDLP), direct laser writing (DLW), laser-induced forward transfer (LIFT) and volumetric bioprinting. Detailed descriptions about these methods can be found in other reviews ( Assenbergh et al, 2018 ; Pagac et al, 2021 ; Hon et al, 2008 ; Hribar et al, 2014 ; Engelhardt 2013 ; Zheng et al, 2020 ; Nguyen and Narayan, 2017 ; Serra and Piqué, 2019 ). These technologies use the energy from the laser to initiate polymerization of photo-crosslinkable materials during the printing without the need of a nozzle, which conveys the advantage that high-viscosity bioinks can be used, unlike in inkjet and extrusion-based bioprinting techniques.…”

Section: D Bioprinting For Tissue Modelsmentioning

confidence: 99%

“…Volumetric bioprinting is a relatively recent and promising technology that overcomes speed limitations of the layer-by-layer printing approach, opening the possibility of printing complex centimeter-scale structures in seconds ( Bernal et al, 2019 ). One of the main drawbacks of this set of technologies when using bioinks is that the laser light and the heat generated can damage cells, affecting viability ( Wang et al, 2009 ; Gudapati et al, 2014 ; Zheng et al, 2020 ). A strategy currently being explored to improve cell viability is the development of bioinks that can use lower cytotoxicity visible light during the printing process ( Zheng et al, 2020 ).…”

Section: D Bioprinting For Tissue Modelsmentioning

confidence: 99%

3D Bioprinting Strategies, Challenges, and Opportunities to Model the Lung Tissue Microenvironment and Its Function

Carpio

Dabaghi

Ungureanu

et al. 2021

Front. Bioeng. Biotechnol.

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Human lungs are organs with an intricate hierarchical structure and complex composition; lungs also present heterogeneous mechanical properties that impose dynamic stress on different tissue components during the process of breathing. These physiological characteristics combined create a system that is challenging to model in vitro. Many efforts have been dedicated to develop reliable models that afford a better understanding of the structure of the lung and to study cell dynamics, disease evolution, and drug pharmacodynamics and pharmacokinetics in the lung. This review presents methodologies used to develop lung tissue models, highlighting their advantages and current limitations, focusing on 3D bioprinting as a promising set of technologies that can address current challenges. 3D bioprinting can be used to create 3D structures that are key to bridging the gap between current cell culture methods and living tissues. Thus, 3D bioprinting can produce lung tissue biomimetics that can be used to develop in vitro models and could eventually produce functional tissue for transplantation. Yet, printing functional synthetic tissues that recreate lung structure and function is still beyond the current capabilities of 3D bioprinting technology. Here, the current state of 3D bioprinting is described with a focus on key strategies that can be used to exploit the potential that this technology has to offer. Despite today’s limitations, results show that 3D bioprinting has unexplored potential that may be accessible by optimizing bioink composition and looking at the printing process through a holistic and creative lens.

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Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review

Cited by 118 publications

References 106 publications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

3D Bioprinting Strategies, Challenges, and Opportunities to Model the Lung Tissue Microenvironment and Its Function

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