Visfatin levels in non-obese, obese, and insulin resistant adolescents

Abstract

Background preterm infants are vulnerable to iron deficiency (ID) Background Adipose tissue is not merely a site for energy storage, but is also the largest endocrine organ, secreting various adipocytokines. plasma visfatin, an adipocytokine predominantly secreted from visceral adipose tissue, has insulin-mimetic effects, and has been closely linked to insulin resistance. Objective To compare plasma visfatin levels between obese and non-obese adolescents, as well as between obese adolecents with and without insulin resistance. Methods This cross-sectional study was conducted in students who attended three senior high schools in padang. Subjects comprised 28 obese and 28 non-obese adolescents. The age of the subjects ranged from 14-18 years. Obesity criteria were based on body mass index (BMI) measurements. Fasting serum glucose level was measured by glucose hexokinase photometry and serum insulin was measured by chemiluminesence immunoassay. plasma visfatin was measured by enzyme-linked immunosorbent assay (ELISA). The insulin resistance index was estimated from fasting serum insulin and glucose levels using the homeostatic model assessment for insulin resistance (HOMA-IR). Differences in the variables were tested using independent T-test and Mann-Whitney test, depending on the distribution of the variables. Results The mean plasma visfatin level was significantly higher in the obese than in the control group [2.55 (SD 1.54) vs. 1.61 (SD 0.64) ng/mL, respectively; (p=0.005)]. The insulin resistant group had significantly higher mean plasma visfatin level than the non-resistant group [3.61 (SD 1.59) vs. 1.96 (SD 1.18) ng/mL, respectively; (p=0.004)]. Conclusion Obese adolescents with insulin resistance have signifcantly higher plasma visfatin levels compared to those without insulin resistance.

The Relationship Between Serum Visfatin, Blood Glucose, Lipid Metabolism and Nonalcoholic Fatty liver Disease in Simple Obese Children

“…Visfatin binds to the insulin receptor at a site differ from that of insulin and causes hypoglycemia by stimulating glucose utilization in adipocytes and myocytes and reducing glucose release from liver. [34] However, Fukuharaet al,(2005) and Li Hui-ling et al,(2015) found that Type 1 diabetic children and adolescents had a significantly lower Visfatin level compared to controls and no difference of serum Visfatin levels between the healthy and overweight children and the difference only was between the healthy and obese children [35,25],also Ihsan et al,(2017) published that overweight/obese individuals there was negative relation between Visfatin level and anthropometric and lipid profile parameters, which can be explained by functional healthy fat tissue in this early life time even in a group of patients with increased body fat. [36] In our study there was a significant difference between the obese children and healthy ones in the ultrasonographic findings of NAFLD and between the obese children and overweight ones with the frequency of 65.6% and 26.7%, respectively.…”

Serum Visfatin, Blood Glucose, Lipid Metabolism and Nonalcoholic Fatty liver Disease in Simple Obese Children

“…Lipid accumulation in the liver leads to hepatic inflammation and cytokine production. [36][37][38][39][40] Our results showed the ROC for serum Visfatin as a predictor of fatty liver in obesity, with sensitivity of 78.1% and specificity of 61.4% .…”

Serum visfatin levels in obese and non-obese individuals; A comparative cross-sectional study.

“…4 These Adipocytokines primarily regulates the body weight, food intake, insulin resistance, immunity and inflammatory activities. 5 Visfatin is a proinflammatory adipocytokine, also known as pre-ß cell colony-enhancing factor 1(pBEF-1). 6 This cytokine is a protein comprising nearly 500 amino acids, predominantly produced by the human visceral adipose tissues (VAT).…”

“…It is involved in triglyceride metabolism and adipocyte proliferation. 5,7 Several studies have reported a significant association between serum visfatin level and obesity. 1,3,7 A study involving the Taiwanese population indicated that serum visfatin levels are closely linked with abdominal obesity and type 2 DM.…”