Viscometer validation studies for routine and experimental hemorheological measurements

Kovács, D; Totsimon, Kinga; Biró, Katalin T.; Kenyeres, Péter; Juricskay, I.; Késmárky, Gábor; Tóth, Kálmán; Tóth, András

doi:10.3233/ch-170301

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…Approximately 0.5 ml of venous blood sample was used, which was processed at a controlled temperature of 37°C, in the Brookfield AMETEK brand viscometer, model DV2T LV CP (cone-plate), and BV values were expressed in poises (P); the measurement was performed in accordance with the existing regulations 14,15 .…”

Section: Blood Viscosity Measurementmentioning

confidence: 99%

Does blood viscosity affect cerebral blood flow? A study in a population living in a high-altitude city

Huamaní

Bayona-Pancorbo²,

Sarmiento

et al. 2023

Preprint

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Background: Viscosity affects flows by increasing resistance to movement; therefore, variations in blood viscosity (BV) levels could modify the cerebral blood flow. Objective: This study aimed to determine the level of correlation between BV and cerebral blood flow in people acclimated to chronic hypoxia who have high BV levels. Methods: Prospective observational study was conducted among clinically healthy young adults living in the city of Cusco (3,399 m above sea level). All participants were examined at low and high shear rates (75 and 300 sec1) to simulate the dynamic component of BV. A transcranial Doppler study of the middle cerebral artery was performed to measure systolic, diastolic, and mean flow velocities (FVs) and resistance and pulsatility indices (PIs). Results: A total of 131 participants were included. The median viscosity levels were 5.01cP [interquartile range (IQR): 4.45, 5.73cP] at 300 sec1 and 6.16 cP [IQR: 5.58, 7.20 cP] at 75 sec1, the mean FV was 57 m/s [IQR: 50, 65 m/s5], and the PI was 0.91 [0.86, 1.02]. BV was negatively correlated with mean FV (r: -0.17, p=0.007), while it showed no correlation with other values of blood flow, resistance, or PI. Conclusions: Changes in BV levels have a minimal impact on the mean FV but not on other parameters. This finding suggests that in young and clinically healthy individuals, there are autoregulation mechanisms that compensate for BV variations, although they are not completely understood.

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Section: Blood Viscosity Measurementmentioning

confidence: 99%

Does blood viscosity affect cerebral blood flow? A study in a population living in a high-altitude city

Huamaní

Bayona-Pancorbo²,

Sarmiento

et al. 2023

Preprint

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“…If samples cannot be measured in this period, they are usually placed in the refrigerator and measured on the next business day. Still in the study by Kovacs et al, 25 the BV was significantly lower after 3 hours at 37°C in the Shear rates of 50 and 100 s‐1. The study by Horner et al 26 found similar results, as they identified a time of approximately 3 hours as the maximum time after the initial test so that accurate rheological tests could be performed on blood samples.…”

Section: Discussionmentioning

confidence: 78%

“…Kovacs et al 25 concluded that samples can be stored for up to 48 hours, at 4°C, without affecting the measured values, but storage at 37°C for several hours is not recommended. Therefore, when storing blood samples, one should refrigerate them when the storage time is long, above four hours.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the storage time of the samples, according to Kovacs et al, 25 samples are generally not measured instantly after sampling; therefore, the stability of the values of viscosity measured must also be checked at different relevant times and temperatures. Samples are usually stored at room temperature, if measured within working hours.…”

Section: Discussionmentioning

confidence: 99%

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Standardization for obtaining blood viscosity: A systematic review

Arruda

Silva

Galduróz

et al. 2021

European J of Haematology

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Introduction There is evidence to suggest that blood viscosity (BV) is involved in several pathological processes. In this review, we evaluated the different methods of BV acquisition, analyzing the sample storage time, the storage temperature, the acquisition time, the acquisition temperature, sample volume, and shear rates, in order to standardize this technique. Methods We selected 50 articles with methods of obtaining BV, evaluating pathologies through BV, comparing rheological equipment, monitoring, and regulating BV. Results and conclusion Measurements should be obtained as soon as possible, to reduce hemorheological changes. It is necessary to refrigerate them at 4°C when the storage time is long. The acquisition time is related to the equipment used. BV measurements at 37°C will represent the real BV in vivo more faithfully. In order to understand the BV phenomena, the shear rates must be between 0.1 and 1000 s‐1. There is a wide variety of equipment available for measuring the BV.

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“…Capillary and rotational viscometers, as well as falling body viscometers, are the most frequently used for blood viscosity measurements. For example, the Brookfield rotational viscometer with the UL adapter for low dynamic viscosity in the range from 1 to 10 mPa•s [19] allows measuring fluid viscosity as a shear rate function [24,25,18,26,17,27]. The test fluid capacity for this adapter is approximately 16 ml [19] which is a significant disadvantage.…”

Section: Literature Reviewmentioning

confidence: 99%

A method to measure non-Newtonian fluids viscosity using inertial viscometer with a computer vision system

Kornaeva

Stebakov

Kornaev

et al. 2023

International Journal of Mechanical Sciences

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Viscometer validation studies for routine and experimental hemorheological measurements

Abstract: Thorough validation studies are required before starting experimental and routine viscosity measurements.

Cited by 8 publications

References 11 publications

Does blood viscosity affect cerebral blood flow? A study in a population living in a high-altitude city

Does blood viscosity affect cerebral blood flow? A study in a population living in a high-altitude city

Standardization for obtaining blood viscosity: A systematic review

A method to measure non-Newtonian fluids viscosity using inertial viscometer with a computer vision system

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