“…Another group of assays are viscoelastic coagulation assays, such as rotational thromboelastometry (ROTEM) and thromboelastography (TEG), which provide a global measure of fibrin clot formation in whole blood. 17,37 While the clinical utility of these assays for managing perioperative coagulopathy has been shown, [37][38][39] they suffer from the same limitation of end-point assays in that they do not measure thrombin generation specifically. 30 Nevertheless, several parameters derived from the clotting curves of these assays indirectly reflect the course of thrombin generation.…”