“…However, the question remains if the model is disease-specific or, in view of the findings discussed above, a representation of general disease phenomena. Therefore, its diagnostic potential should be confirmed by cross validation with more samples from patients presenting with VL and relevant clinical controls (e.g., systemic inflammatory diseases that affect the liver, such as lupus, 47 and neoplasias involving bone marrow such as multiple myeloma, 82 etc.). It is worth mentioning at this point that VL can be confused with lupus and lymphoma and this can be fatal for the VL patient if not treated promptly because of this confusion.…”