“…Impairment of the epithelial barrier function, by trauma or maceration greatly predisposes to The apparent failure of the immune system in otherwise healthy individuals to clear warts for months or years is because Langerhans' cell numbers are reduced within warts and T lymphocytes are rare within the epidermal compartment. 1,7 Common warts are hyperkeratotic, exophytic, domeshaped papules or plaques that are typically associated with HPV-1, 2, 4, 27 or 57. They are most frequently located on the fingers and dorsal surfaces of the hands or in other sites prone to trauma such as the knees or elbows.…”