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Cited by 128 publications
(61 citation statements)
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References 19 publications
(61 reference statements)
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“…The changes in corticosterone were accompanied by neurochemical ones. MHPG and MHPG:NE ratios were elevated in all brain regions studied, but the magnitude of the responses was greater in the hypothalamus than in the other brain regions studied [158]. DOPAC and DOPAC:DA ratios, and HVA and HVA:DA ratios were not significantly altered.…”
Section: Neurochemical Responses To Infectionsmentioning
confidence: 67%
See 1 more Smart Citation
“…The changes in corticosterone were accompanied by neurochemical ones. MHPG and MHPG:NE ratios were elevated in all brain regions studied, but the magnitude of the responses was greater in the hypothalamus than in the other brain regions studied [158]. DOPAC and DOPAC:DA ratios, and HVA and HVA:DA ratios were not significantly altered.…”
Section: Neurochemical Responses To Infectionsmentioning
confidence: 67%
“…Infusion of the virus into the lungs (the normal site of influenza virus infection) induced a chronic elevation of plasma corticosterone [158]. This contrasted with the transient elevation seen with most commonly studied stressors.…”
Section: Neurochemical Responses To Infectionsmentioning
confidence: 83%
“…Macrophages are activated either by engulfing antigen or by a number of chemical signals that bind to surface receptors on the macrophage. Activation of macrophages with virus or bacterial endotoxin produces a release of IL-1 and a subsequent alteration in the electrical activity of the brain (Saphier, 1992), as well as metabolism of the neurotransmitters norepinephrine, serotonin, and dopamine in a number of discrete brain regions (Dunn, Powell, & Small, 1989). These CNS changes to virus and endotoxin are known to be produced by IL-1, because an antagonist to the IL-1 receptor blocks them and the peripheral or central administration of IL-1 produces them (Dunn, 1993).…”
Section: Connections From the Immune System To The Central Nervous Symentioning
confidence: 99%
“…Influenza A virus (IAV) and other viruses are known to activate both the hypothalamic-pituitary axis (HPA) and the SNS (19). Previous studies by Sheridan et al have clearly demonstrated that the nervous system can have an impact on IAV responses (reviewed in ref.…”
mentioning
confidence: 99%