Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer

Ghanaat, Momeneh; Goradel, Nasser Hashemi; Arashkia, Arash; Ebrahimi, Nader; Ghorghanlu, Sajjad; Malekshahi, Ziba Veisi; Fattahi, Esmail; Negahdari, Babak; Kaboosi, Hami

doi:10.1038/s41401-021-00616-5

Cited by 14 publications

(10 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We selected therapeutic targets. The E6 and E7 viral oncogenes encode oncoproteins that disrupt cell cycle regulation and enhance cell proliferation by inactivating the tumor suppressors p53 and RB, respectively (Longworth and Laimins, 2004;Strickland and Vande Pol, 2016;Ghanaat et al, 2021). P53 inactivation mediated by E6 or p53 mutations may be a key step in the development of cervical cancer (Scheffner et al, 1991;Park et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

Xiong

Mei

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The p53 gene has the highest mutation frequency in tumors, and its inactivation can lead to malignant transformation, such as cell cycle arrest and apoptotic inhibition. Persistent high-risk human papillomavirus (HR-HPV) infection is the leading cause of cervical cancer. P53 was inactivated by HPV oncoprotein E6, promoting abnormal cell proliferation and carcinogenesis. To study the treatment of cervical intraepithelial neoplasia (CIN) and cervical cancer by restoring p53 expression and inactivating HPV oncoprotein, and to verify the effectiveness of nano drugs based on nucleic acid delivery in cancer treatment, we developed poly (beta-amino ester)537, to form biocompatible and degradable nanoparticles with plasmids (expressing p53 and targeting E7). In vitro and in vivo experiments show that nanoparticles have low toxicity and high transfection efficiency. Nanoparticles inhibited the growth of xenograft tumors and successfully reversed HPV transgenic mice’s cervical intraepithelial neoplasia. Our work suggests that the restoration of p53 expression and the inactivation of HPV16 E7 are essential for blocking the development of cervical cancer. This study provides new insights into the precise treatment of HPV-related cervical lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

Xiong

Mei

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Adenoviruses (Ads) and non-enveloped viruses containing ~ 36 kb double-stranded DNA (dsDNA) encode E1-E4 and L1-L5 as early and late genes, respectively [ 41 ]. Structurally, Ads capsid is composed of major proteins, including hexon, penton base, and fiber, and minor proteins, including IIIa, VI, VIII, and IX [ 42 ].…”

Section: Oncolytic Virotherapymentioning

confidence: 99%

A review on the advances and challenges of immunotherapy for head and neck cancer

et al. 2021

View full text Add to dashboard Cite

Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells with immune cells in the tumor microenvironment, immunotherapy of HNCs, along with traditional treatments such as chemotherapy, radiotherapy, and surgery, has attracted much attention. Four main immunotherapy strategies in HNCs have been developed, including oncolytic viruses, monoclonal antibodies, chimeric antigen receptor T cells (CAR-T cells), and therapeutic vaccines. Oncorine (H101), an approved oncolytic adenovirus in China, is the pioneer of immunotherapy for the treatment of HNCs. Pembrolizumab and nivolumab are mAbs against PD-L1 that have been approved for recurrent and metastatic HNC patients. To date, several clinical trials using immunotherapy agents and their combination are under investigation. In this review, we summarize current the interaction of tumor cells with immune cells in the tumor microenvironment of HNCs, the main strategies that have been applied for immunotherapy of HNCs, obstacles that hinder the success of immunotherapies in patients with HNCs, as well as solutions for overcoming the challenges to enhance the response of HNCs to immunotherapies.

show abstract

“…Patients with OCD, on the other hand, may suffer significant consequences, including a lower standard of life. 25,26 One of the most common mistakes in recognizing OCD is compulsion and obsession as inflexible personality traits in OCD classification. Although it is difficult to distinguish between axis I disorders, including the personality traits of a person with OCD, and axis II disorders, such as OC personality disorder, there is a difference between OCD and perfectionist behaviors or extreme conscientiousness.…”

Section: The Main Ways For Ocd Diagnosismentioning

confidence: 99%

Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder

Asl

Asgari

Bakhti

2021

Int Clin Neurosci J

View full text Add to dashboard Cite

Background: Obsessive-compulsive disorder (OCD) is a severe psychological disorder that can be very disabling. Recent increasing neuroscientific data about OCD has provided important evidence that has started to change our knowledge about treatment. This paper offers an applied perspective of neuroscience on diagnosis and treatment preparation for people with OCD disease. The main aim is to enhance clinician-researcher communication to promote the conversion of developments in neuroscience research into better treatment for patients with OCD. Methods: A PubMed search was performed using the keywords "obsessive-compulsive disorder", "neuroimaging methods", "neuroscience", and "neurological treatment". The search provided sufficient articles published in peer-reviewed journals from 1995 to 2021. The data were obtained from these various sources and were included in this review. Results: The advancement of neurotherapeutic techniques targeting the cortico-striatal-thalamo-cortical (CSTC) circuit is the subject of a circuit dysregulation system. Also, according to neuroimaging studies, reductions in D2 receptors (about -18%), GABAA receptors (-15%), and cingulate 5-HT1A receptors (-18%) in patients with OCD were reported compared with healthy controls. Conclusion: The result suggests that DA, 5-HT, and GABA have considerable roles in anxiety- and compulsion-related disorders such as OCD. For patients with OCD, these core neuroscience themes collectively guide formulation and clinical preparation.

show abstract

Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer

Cited by 14 publications

References 142 publications

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

A review on the advances and challenges of immunotherapy for head and neck cancer

Treatment Approaches Based on Neuroscientific Data in Patients With Obsessive-Compulsive Disorder

Contact Info

Product

Resources

About