Abstract:Recently, the worldwide propagation of clonal CTX-M-15-producing
isolates, namely ST131 and O25b:H4, has been reported. Like the majority of extra-intestinal pathogenic
isolates, the pandemic clone ST131 belongs to phylogenetic group B2, and has recently been shown to be highly virulent in a mouse model, even though it lacks several genes encoding key virulence factors (Pap, Cnf1 and HlyA). Using two animal models,
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